INT69474

Context Info Confidence 0.64 First Reported 1997 Last Reported 1997 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.04

nucleus (T) DNA binding (T) cytoplasm (T)

Anatomy Link Frequency brain 1 T (Mus musculus)

Pain Link Frequency Relevance Heat Delta opioid receptors 1 72.92 Pain 1 47.84

Disease Link Frequency Relevance Heat Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results indicated that the N-terminal sequence and the amino acids in position 4 and 5 are critical to deltorphin analogue BBB permeability and biological stability, i.e., t 1/2 brain; 4.8 hr- [D-Ala2]deltorphin I; > 15 hr- [D-Ala2, Ser4, D-Ala5]deltorphin.

Protein_catabolism (stability) of t 1 in brain

1) Confidence 0.64 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152390 Disease Relevance 0 Pain Relevance 0.04

General Comments

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