INT69621

Context Info Confidence 0.42 First Reported 1997 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 4.10 Pain Relevance 2.85

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse) nucleus (Hpse) carbohydrate metabolic process (Hpse) lysosome (Hpse)

Anatomy Link Frequency plasma 2 neurons 2 Hpse (Rattus norvegicus)

Pain Link Frequency Relevance Heat cocaine 11 100.00 Morphine 11 99.92 Multiple sclerosis 26 99.84 Dopamine 19 98.68 opiate 1 97.40 Serotonin 7 97.04 Desipramine 2 96.52 Opioid 3 96.08 Norepinephrine uptake inhibitor 2 96.04 fluoxetine 2 95.96

Disease Link Frequency Relevance Heat Stress 185 99.98 Multiple Sclerosis 132 99.84 Targeted Disruption 23 99.08 Sprains And Strains 3 97.36 Disease 25 96.48 Appetite Loss 1 93.24 Fever 1 92.84 Cushing's Syndrome / Hypercortisolism 2 86.80 INFLAMMATION 64 83.52 Cytomegalovirus Infection 1 78.60

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Corticotropin releasing hormone (CRH) neurons located in the hypothalamus are important for HPA activation.

Positive_regulation (important) of Positive_regulation (activation) of HPA in neurons

1) Confidence 0.42 Published 2005 Journal Brain Res. Bull. Section Abstract Doc Link 15833600 Disease Relevance 0.19 Pain Relevance 0.30

Females also showed enhanced HPA axis activation following administration of the dopamine uptake inhibitor GBR 12909, the serotonin uptake inhibitor fluoxetine, and the norepinephrine uptake inhibitor desipramine.

Positive_regulation (enhanced) of Positive_regulation (activation) of HPA associated with desipramine, norepinephrine uptake inhibitor, dopamine, serotonin and fluoxetine

2) Confidence 0.41 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9165495 Disease Relevance 0 Pain Relevance 0.49

No gender difference in HPA axis activation was observed in a dose-response study of cocaine-induced HPA activation in 10 day old rats.

Positive_regulation (cocaine-induced) of Positive_regulation (activation) of HPA associated with cocaine

3) Confidence 0.34 Published 1997 Journal Neuropsychopharmacology Section Abstract Doc Link 9165495 Disease Relevance 0 Pain Relevance 0.53

The present data provide evidence of an increasing attenuation of stress-induced HPA activation between D16 and D19 of pregnancy.

Positive_regulation (induced) of Positive_regulation (activation) of HPA associated with stress

4) Confidence 0.20 Published 2010 Journal Brain Research Section Body Doc Link PMC2994639 Disease Relevance 0.67 Pain Relevance 0.10

These findings, that the effects of morphine on HPA activation or POMC mRNA expression depend on the presence of stress, suggest a counter-regulatory role of opiates on a stress response and opioid gene expression.

Positive_regulation (depend) of Positive_regulation (activation) of HPA associated with stress, opiate, opioid and morphine

5) Confidence 0.16 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10556776 Disease Relevance 0.33 Pain Relevance 0.96

However, elevated HPA activation in MS patients has been shown: in one study patients with MS had significantly higher plasma cortisol levels at baseline compared to matched controls.

Positive_regulation (elevated) of Positive_regulation (activation) of HPA in plasma associated with multiple sclerosis

6) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.99 Pain Relevance 0.29

It should be noted that the action of IL-6 is downstream of IL-1, as both induction of IL-6 and activation of HPA axis are inhibited by transgenic inactivation of type I IL-1 receptor (698).

Positive_regulation (induction) of Positive_regulation (activation) of HPA associated with targeted disruption

7) Confidence 0.05 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.77 Pain Relevance 0.18

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