INT69886

From wiki-pain
(Difference between revisions)
Jump to: navigation, search
(Generated page)
(Generated page)
 
(4 intermediate revisions by one user not shown)
Line 7: Line 7:
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 3.7858241800
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.76
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| First Reported
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| First Reported
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1997
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:1997|1997]]
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Last Reported
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Last Reported
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2005
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2005|2005]]
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Negated
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Negated
Line 22: Line 22:
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Reported most in
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Reported most in
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| NULL
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| Abstract
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Documents
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Documents
Line 29: Line 29:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Total Number
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Total Number
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 13
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 13
 +
|-
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 2.98
 +
|-
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;" align="center"| 12.77
 
|-
 
|-
 
|}
 
|}
Line 42: Line 48:
 
fontcolor=white,
 
fontcolor=white,
 
label="Ngf",
 
label="Ngf",
URL="Ngf"
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=G:310738"
 
];
 
];
 
node2
 
node2
Line 49: Line 55:
 
style=filled,
 
style=filled,
 
fillcolor=yellow,
 
fillcolor=yellow,
URL=Positive_regulation
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=E:Positive_regulation"
 
];
 
];
 
node3
 
node3
Line 57: Line 63:
 
fontcolor=white,
 
fontcolor=white,
 
label="Calca",
 
label="Calca",
URL="Calca"
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=G:24241"
 
];
 
];
 
subgraph cluster_0 {
 
subgraph cluster_0 {
Line 71: Line 77:
 
{| cellspacing=5 cellpadding=2
 
{| cellspacing=5 cellpadding=2
 
|-
 
|-
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[extracellular space]] ([[Ngf]], [[Calca]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:extracellular space|extracellular space]] ([[G:310738|Ngf]], [[G:24241|Calca]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[aging]] ([[Ngf]], [[Calca]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:aging|aging]] ([[G:310738|Ngf]], [[G:24241|Calca]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[extracellular region]] ([[Ngf]], [[Calca]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:extracellular region|extracellular region]] ([[G:310738|Ngf]], [[G:24241|Calca]])
 
|-
 
|-
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[signal transduction]] ([[Ngf]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:signal transduction|signal transduction]] ([[G:310738|Ngf]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[nucleus]] ([[Calca]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:nucleus|nucleus]] ([[G:24241|Calca]])
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[intracellular]] ([[Calca]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:intracellular|intracellular]] ([[G:24241|Calca]])
 
|-
 
|-
 
|}
 
|}
Line 85: Line 91:
 
{| cellpadding=3 cellspacing=0  
 
{| cellpadding=3 cellspacing=0  
 
|-
 
|-
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Anatomy Mention
+
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Anatomy Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;" align="center"| Frequency
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;" align="center"| Frequency
 
|-
 
|-
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[anat:157|nerve]]
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[A:nerve|nerve]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|4
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|4
 
|-
 
|-
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[CL:0000540|neurons]]
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[A:neurons|neurons]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|2
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|2
 
|-
 
|-
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[anat:1585|sensory neurons]]
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[A:sensory neurons|sensory neurons]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|1
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|1
 
|-
 
|-
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[anat:461|outflow]]
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[A:outflow|outflow]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|1
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|1
 
|-
 
|-
Line 108: Line 114:
 
|-
 
|-
 
|}
 
|}
 +
 
|-
 
|-
|colspan="3"|
+
|}
{| cellspacing=1 cellpadding=1
+
{| cellspacing=2 cellpadding=2
|
+
| style="vertical-align: top"|
 
{| cellspacing=1 cellpadding=5 align=center
 
{| cellspacing=1 cellpadding=5 align=center
 
|-
 
|-
| style="color: black; background:#AAFCFB; white-space:wrap;"| '''Pain Relations:'''
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Pain Link
(frequency)
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Trigeminal ganglion neurons]] (6)
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Relevance
{{#icon: cold.png|Quite Low}}
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[vascular symptom complex]] (36)
+
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Spinal cord]] (28)
+
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Neuropeptides]] (106)
+
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[intrathecal]] (6)
+
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Calcitonin gene-related peptide]] (614)
+
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
+
 
|-
 
|-
| style="color: black; background:#AAFCFB; white-space:wrap;"| '''Disease Relations:'''
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:Nerve growth factor|Nerve growth factor]]
(frequency)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 647
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Hyperalgesia]] (42)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Neurogenic Inflammation]] (6)
+
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Decapitation]] (6)
+
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Nociception]] (53)
+
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Headache Disorders]] (6)
+
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Injury]] (150)
+
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
+
|}
+
 
+
 
|-
 
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:Calcitonin gene-related peptide|Calcitonin gene-related peptide]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 614
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:trigeminal ganglion|trigeminal ganglion]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 354
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:Neuropeptide|Neuropeptide]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 106
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:substance P|substance P]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 60
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:Inflammation|Inflammation]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 36
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:qutenza|qutenza]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 312
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 99.20
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:c fibre|c fibre]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 11
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 98.84
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:agonist|agonist]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 36
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 96.88
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:Cannabinoid|Cannabinoid]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 12
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 96.12
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
 
|}
 
|}
 +
|
 +
| style="vertical-align: top"|
 +
{| cellspacing=1 cellpadding=5 align=center
 
|-
 
|-
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Disease Link
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Relevance
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Ganglion Cysts|Ganglion Cysts]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 438
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Nociception|Nociception]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 53
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:INFLAMMATION|INFLAMMATION]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 30
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 100.00
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Hyperalgesia|Hyperalgesia]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 42
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 92.80
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Injury|Injury]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 150
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 89.28
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Pain|Pain]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 20
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 68.60
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Hypersensitivity|Hypersensitivity]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 12
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 7.04
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Headache|Headache]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 36
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5.00
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Apoptosis|Apoptosis]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 12
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5.00
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Nervous System Injury|Nervous System Injury]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 12
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5.00
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 +
|-
 +
|}
 
|}
 
|}
  
Line 156: Line 246:
 
| style="color: black; background:white; white-space:wrap;"| Key:
 
| style="color: black; background:white; white-space:wrap;"| Key:
 
| style="color: black; background:#FFFF00; border: 1px solid lightgray; white-space:wrap;"| Protein
 
| style="color: black; background:#FFFF00; border: 1px solid lightgray; white-space:wrap;"| Protein
 +
| style="color: black; background:#ADFF2F; border: 1px solid lightgray; white-space:wrap;"| Mutation
 
| style="color: black; background:#B0E0E6; border: 1px solid lightgray; white-space:wrap;"| Event
 
| style="color: black; background:#B0E0E6; border: 1px solid lightgray; white-space:wrap;"| Event
 
| style="color: black; background:#FFDEAD; border: 1px solid lightgray; white-space:wrap;"| Anatomy
 
| style="color: black; background:#FFDEAD; border: 1px solid lightgray; white-space:wrap;"| Anatomy
Line 161: Line 252:
 
| style="color: black; background:#D3D3D3; border: 1px solid lightgray; white-space:wrap;"| Speculation
 
| style="color: black; background:#D3D3D3; border: 1px solid lightgray; white-space:wrap;"| Speculation
 
| style="color: black; background:#FFA07A; border: 1px solid lightgray; white-space:wrap;"| Pain term
 
| style="color: black; background:#FFA07A; border: 1px solid lightgray; white-space:wrap;"| Pain term
 +
| style="color: black; background:#FFA07A; border: 1px solid lightgray; white-space:wrap;"| Disease term
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| In the adult rat, <span style="background-color:#FFDEAD">nerve</span> growth factor (<span style="background-color:#FFFF00">NGF</span>) <span style="background-color:#B0E0E6">upregulates</span> the nociceptive peptide substance P (SP) and calcitonin gene-related peptide (<span style="background-color:#FFFF00">CGRP</span>) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.  
+
| In the adult rat, <span style="background-color:#FFA07A">nerve growth factor</span> (<span style="background-color:#FFA07A">NGF</span>) <span style="background-color:#B0E0E6">upregulates</span> the <span style="background-color:#FFA07A">nociceptive</span> peptide <span style="background-color:#FFA07A">substance P</span> (<span style="background-color:#FFA07A">SP</span>) and <span style="background-color:#FFA07A">calcitonin gene-related peptide</span> (<span style="background-color:#FFFF00">CGRP</span>) in neuronal cell bodies of <span style="background-color:#FFA07A">C fibres</span> but the effects of <span style="background-color:#FFA07A">NGF</span> on release of these <span style="background-color:#FFA07A">neuropeptides</span> from the central afferent terminals have not been reported.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NGF'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">upregulates</span>) of <span style="color:#800000">'''CGRP'''</span> in <span style="color:#808000">nerve</span>
+
|  [[G:310738|<span style="color:#800000">'''NGF'''</span>]] [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">upregulates</span>) of [[G:24241|<span style="color:#800000">'''CGRP'''</span>]] in [[A:nerve|<span style="color:#808000">nerve</span>]] associated with <span style="color:#FF0000">'''nociception'''</span>, <span style="color:#FF0000">'''c fibre'''</span>, <span style="color:#FF0000">'''nerve growth factor'''</span>, <span style="color:#FF0000">'''neuropeptide'''</span>, <span style="color:#FF0000">'''calcitonin gene-related peptide'''</span> and <span style="color:#FF0000">'''substance p'''</span>
 
|-
 
|-
 
|}
 
|}
Line 178: Line 270:
 
! style="color: black; background:white; white-space:nowrap;"| 1)
 
! style="color: black; background:white; white-space:nowrap;"| 1)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.759575030260726
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.76
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1997
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:1997|1997]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Eur. J. Neurosci.|Eur. J. Neurosci.]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Abstract
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9182964 9182964]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9182964 9182964]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.10
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.02
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| In the adult rat, <span style="background-color:#FFFF00">nerve growth factor</span> (NGF) <span style="background-color:#B0E0E6">upregulates</span> the nociceptive peptide substance P (SP) and <span style="background-color:#FFFF00">calcitonin gene-related peptide</span> (CGRP) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.  
+
| In the adult rat, <span style="background-color:#FFA07A">nerve growth factor</span> (<span style="background-color:#FFA07A">NGF</span>) <span style="background-color:#B0E0E6">upregulates</span> the <span style="background-color:#FFA07A">nociceptive</span> peptide <span style="background-color:#FFA07A">substance P</span> (<span style="background-color:#FFA07A">SP</span>) and <span style="background-color:#FFA07A">calcitonin gene-related peptide</span> (<span style="background-color:#FFA07A">CGRP</span>) in neuronal cell bodies of <span style="background-color:#FFA07A">C fibres</span> but the effects of <span style="background-color:#FFA07A">NGF</span> on release of these <span style="background-color:#FFA07A">neuropeptides</span> from the central afferent terminals have not been reported.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''nerve growth factor'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">upregulates</span>) of <span style="color:#800000">'''calcitonin gene-related peptide'''</span> in <span style="color:#808000">nerve</span>
+
|  [[G:310738|<span style="color:#800000">'''nerve growth factor'''</span>]] [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">upregulates</span>) of [[G:24241|<span style="color:#800000">'''calcitonin gene-related peptide'''</span>]] in [[A:nerve|<span style="color:#808000">nerve</span>]] associated with <span style="color:#FF0000">'''nociception'''</span>, <span style="color:#FF0000">'''c fibre'''</span>, <span style="color:#FF0000">'''nerve growth factor'''</span>, <span style="color:#FF0000">'''neuropeptide'''</span>, <span style="color:#FF0000">'''calcitonin gene-related peptide'''</span> and <span style="color:#FF0000">'''substance p'''</span>
 
|-
 
|-
 
|}
 
|}
Line 205: Line 301:
 
! style="color: black; background:white; white-space:nowrap;"| 2)
 
! style="color: black; background:white; white-space:nowrap;"| 2)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.759575030260726
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.76
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1997
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:1997|1997]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Eur. J. Neurosci.|Eur. J. Neurosci.]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Abstract
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9182964 9182964]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9182964 9182964]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.10
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.02
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| In the adult rat, <span style="background-color:#FFDEAD">nerve</span> growth factor (<span style="background-color:#FFFF00">NGF</span>) <span style="background-color:#B0E0E6">upregulates</span> the nociceptive peptide substance P (SP) and <span style="background-color:#FFFF00">calcitonin gene-related peptide</span> (CGRP) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.  
+
| In the adult rat, <span style="background-color:#FFA07A">nerve growth factor</span> (<span style="background-color:#FFA07A">NGF</span>) <span style="background-color:#B0E0E6">upregulates</span> the <span style="background-color:#FFA07A">nociceptive</span> peptide <span style="background-color:#FFA07A">substance P</span> (<span style="background-color:#FFA07A">SP</span>) and <span style="background-color:#FFA07A">calcitonin gene-related peptide</span> (<span style="background-color:#FFA07A">CGRP</span>) in neuronal cell bodies of <span style="background-color:#FFA07A">C fibres</span> but the effects of <span style="background-color:#FFA07A">NGF</span> on release of these <span style="background-color:#FFA07A">neuropeptides</span> from the central afferent terminals have not been reported.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NGF'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">upregulates</span>) of <span style="color:#800000">'''calcitonin gene-related peptide'''</span> in <span style="color:#808000">nerve</span>
+
|  [[G:310738|<span style="color:#800000">'''NGF'''</span>]] [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">upregulates</span>) of [[G:24241|<span style="color:#800000">'''calcitonin gene-related peptide'''</span>]] in [[A:nerve|<span style="color:#808000">nerve</span>]] associated with <span style="color:#FF0000">'''nociception'''</span>, <span style="color:#FF0000">'''c fibre'''</span>, <span style="color:#FF0000">'''nerve growth factor'''</span>, <span style="color:#FF0000">'''neuropeptide'''</span>, <span style="color:#FF0000">'''calcitonin gene-related peptide'''</span> and <span style="color:#FF0000">'''substance p'''</span>
 
|-
 
|-
 
|}
 
|}
Line 232: Line 332:
 
! style="color: black; background:white; white-space:nowrap;"| 3)
 
! style="color: black; background:white; white-space:nowrap;"| 3)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.759575030260726
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.76
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1997
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:1997|1997]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Eur. J. Neurosci.|Eur. J. Neurosci.]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Abstract
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9182964 9182964]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9182964 9182964]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.10
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.02
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| In the adult rat, <span style="background-color:#FFFF00">nerve growth factor</span> (NGF) <span style="background-color:#B0E0E6">upregulates</span> the nociceptive peptide substance P (SP) and calcitonin gene-related peptide (<span style="background-color:#FFFF00">CGRP</span>) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.  
+
| In the adult rat, <span style="background-color:#FFA07A">nerve growth factor</span> (<span style="background-color:#FFA07A">NGF</span>) <span style="background-color:#B0E0E6">upregulates</span> the <span style="background-color:#FFA07A">nociceptive</span> peptide <span style="background-color:#FFA07A">substance P</span> (<span style="background-color:#FFA07A">SP</span>) and <span style="background-color:#FFA07A">calcitonin gene-related peptide</span> (<span style="background-color:#FFFF00">CGRP</span>) in neuronal cell bodies of <span style="background-color:#FFA07A">C fibres</span> but the effects of <span style="background-color:#FFA07A">NGF</span> on release of these <span style="background-color:#FFA07A">neuropeptides</span> from the central afferent terminals have not been reported.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''nerve growth factor'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">upregulates</span>) of <span style="color:#800000">'''CGRP'''</span> in <span style="color:#808000">nerve</span>
+
|  [[G:310738|<span style="color:#800000">'''nerve growth factor'''</span>]] [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">upregulates</span>) of [[G:24241|<span style="color:#800000">'''CGRP'''</span>]] in [[A:nerve|<span style="color:#808000">nerve</span>]] associated with <span style="color:#FF0000">'''nociception'''</span>, <span style="color:#FF0000">'''c fibre'''</span>, <span style="color:#FF0000">'''nerve growth factor'''</span>, <span style="color:#FF0000">'''neuropeptide'''</span>, <span style="color:#FF0000">'''calcitonin gene-related peptide'''</span> and <span style="color:#FF0000">'''substance p'''</span>
 
|-
 
|-
 
|}
 
|}
Line 259: Line 363:
 
! style="color: black; background:white; white-space:nowrap;"| 4)
 
! style="color: black; background:white; white-space:nowrap;"| 4)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.759575030260726
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.76
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1997
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:1997|1997]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Eur. J. Neurosci.|Eur. J. Neurosci.]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Abstract
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9182964 9182964]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9182964 9182964]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.10
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.02
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| NGF (1.0 mg/kg s.c.) greatly increased basal and stimulus-evoked SP and CGRP release; at 0.1 mg/kg, <span style="background-color:#FFFF00">NGF</span> did <span style="background-color:#D3D3D3">not</span> affect SP release but significantly <span style="background-color:#B0E0E6">increased</span> <span style="background-color:#FFFF00">CGRP</span> basal <span style="background-color:#FFDEAD">outflow</span> and evoked release.  
+
| <span style="background-color:#FFA07A">NGF</span> (1.0 mg/kg s.c.) greatly increased basal and stimulus-evoked <span style="background-color:#FFA07A">SP</span> and <span style="background-color:#FFA07A">CGRP</span> release; at 0.1 mg/kg, <span style="background-color:#FFFF00">NGF</span> did <span style="background-color:#D3D3D3">not</span> affect <span style="background-color:#FFA07A">SP</span> release but significantly <span style="background-color:#B0E0E6">increased</span> <span style="background-color:#FFFF00">CGRP</span> basal <span style="background-color:#FFDEAD">outflow</span> and evoked release.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NGF'''</span> Neg (not) <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">increased</span>) of <span style="color:#800000">'''CGRP'''</span> in <span style="color:#808000">outflow</span>
+
|  [[G:310738|<span style="color:#800000">'''NGF'''</span>]] Neg (not) [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">increased</span>) of [[G:24241|<span style="color:#800000">'''CGRP'''</span>]] in [[A:outflow|<span style="color:#808000">outflow</span>]] associated with <span style="color:#FF0000">'''nerve growth factor'''</span>, <span style="color:#FF0000">'''calcitonin gene-related peptide'''</span> and <span style="color:#FF0000">'''substance p'''</span>
 
|-
 
|-
 
|}
 
|}
Line 286: Line 394:
 
! style="color: black; background:white; white-space:nowrap;"| 5)
 
! style="color: black; background:white; white-space:nowrap;"| 5)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.66233474860899
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.66
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1997
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:1997|1997]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Eur. J. Neurosci.|Eur. J. Neurosci.]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Abstract
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9182964 9182964]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=9182964 9182964]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.08
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.26
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Much like K+-evoked <span style="background-color:#FFFF00">CGRP release</span>, total CGRP content was <span style="background-color:#B0E0E6">increased</span> significantly by <span style="background-color:#FFFF00">NGF</span> and GDNF treatment, while BDNF had no effect (Fig. 6C).  
+
| Much like K+-evoked <span style="background-color:#FFFF00">CGRP release</span>, total <span style="background-color:#FFA07A">CGRP</span> content was <span style="background-color:#B0E0E6">increased</span> significantly by <span style="background-color:#FFFF00">NGF</span> and GDNF treatment, while BDNF had no effect (Fig. 6C).  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NGF'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">increased</span>) of <span style="color:#800000">'''CGRP release'''</span>
+
|  [[G:310738|<span style="color:#800000">'''NGF'''</span>]] [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">increased</span>) of [[G:24241|<span style="color:#800000">'''CGRP release'''</span>]] associated with <span style="color:#FF0000">'''nerve growth factor'''</span> and <span style="color:#FF0000">'''calcitonin gene-related peptide'''</span>
 
|-
 
|-
 
|}
 
|}
Line 313: Line 425:
 
! style="color: black; background:white; white-space:nowrap;"| 6)
 
! style="color: black; background:white; white-space:nowrap;"| 6)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.608426159345174
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.61
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2005
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2005|2005]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:BMC Neurosci|BMC Neurosci]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC548274 PMC548274]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC548274 PMC548274]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.84
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Much like K+-evoked CGRP release, total <span style="background-color:#FFFF00">CGRP</span> content was <span style="background-color:#B0E0E6">increased</span> significantly by <span style="background-color:#FFFF00">NGF</span> and GDNF treatment, while BDNF had no effect (Fig. 6C).  
+
| Much like K+-evoked <span style="background-color:#FFA07A">CGRP</span> release, total <span style="background-color:#FFA07A">CGRP</span> content was <span style="background-color:#B0E0E6">increased</span> significantly by <span style="background-color:#FFFF00">NGF</span> and GDNF treatment, while BDNF had no effect (Fig. 6C).  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NGF'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">increased</span>) of <span style="color:#800000">'''CGRP'''</span>
+
|  [[G:310738|<span style="color:#800000">'''NGF'''</span>]] [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">increased</span>) of [[G:24241|<span style="color:#800000">'''CGRP'''</span>]] associated with <span style="color:#FF0000">'''nerve growth factor'''</span> and <span style="color:#FF0000">'''calcitonin gene-related peptide'''</span>
 
|-
 
|-
 
|}
 
|}
Line 340: Line 456:
 
! style="color: black; background:white; white-space:nowrap;"| 7)
 
! style="color: black; background:white; white-space:nowrap;"| 7)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.608426159345174
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.61
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2005
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2005|2005]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:BMC Neurosci|BMC Neurosci]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC548274 PMC548274]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC548274 PMC548274]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.83
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Furthermore, <span style="background-color:#FFFF00">NGF</span> and GDNF <span style="background-color:#B0E0E6">increased</span> the releasable pool and total content of <span style="background-color:#FFFF00">CGRP</span> while increasing TRPV1 protein, without increasing its mRNA.  
+
| Furthermore, <span style="background-color:#FFA07A">NGF</span> and GDNF <span style="background-color:#B0E0E6">increased</span> the releasable pool and total content of <span style="background-color:#FFFF00">CGRP</span> while increasing TRPV1 protein, without increasing its mRNA.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NGF'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">increased</span>) of <span style="color:#800000">'''CGRP'''</span>
+
|  [[G:310738|<span style="color:#800000">'''NGF'''</span>]] [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">increased</span>) of [[G:24241|<span style="color:#800000">'''CGRP'''</span>]] associated with <span style="color:#FF0000">'''nerve growth factor'''</span> and <span style="color:#FF0000">'''calcitonin gene-related peptide'''</span>
 
|-
 
|-
 
|}
 
|}
Line 367: Line 487:
 
! style="color: black; background:white; white-space:nowrap;"| 8)
 
! style="color: black; background:white; white-space:nowrap;"| 8)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.439378192736025
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.44
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2005
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2005|2005]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:BMC Neurosci|BMC Neurosci]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC548274 PMC548274]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC548274 PMC548274]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.62
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.35
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| Both <span style="background-color:#FFFF00">NGF</span> and GDNF <span style="background-color:#B0E0E6">increased</span> <span style="background-color:#FFFF00">CGRP</span> content concentration-dependently at every concentration (p < 0.001), with peaks at 10 ng/ml (3.2-fold increase) for NGF and 100 ng/ml (3.0-fold increase) for GDNF (Fig. 6C).  
+
| Both <span style="background-color:#FFFF00">NGF</span> and GDNF <span style="background-color:#B0E0E6">increased</span> <span style="background-color:#FFA07A">CGRP</span> content concentration-dependently at every concentration (p < 0.001), with peaks at 10 ng/ml (3.2-fold increase) for <span style="background-color:#FFA07A">NGF</span> and 100 ng/ml (3.0-fold increase) for GDNF (Fig. 6C).  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NGF'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">increased</span>) of <span style="color:#800000">'''CGRP'''</span>
+
|  [[G:310738|<span style="color:#800000">'''NGF'''</span>]] [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">increased</span>) of [[G:24241|<span style="color:#800000">'''CGRP'''</span>]] associated with <span style="color:#FF0000">'''nerve growth factor'''</span> and <span style="color:#FF0000">'''calcitonin gene-related peptide'''</span>
 
|-
 
|-
 
|}
 
|}
Line 394: Line 518:
 
! style="color: black; background:white; white-space:nowrap;"| 9)
 
! style="color: black; background:white; white-space:nowrap;"| 9)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.439378192736025
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.44
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2005
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2005|2005]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:BMC Neurosci|BMC Neurosci]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC548274 PMC548274]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC548274 PMC548274]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.80
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| As in the case with CAP, the effects of AEA and ACEA on evoked <span style="background-color:#FFFF00">CGRP release</span> were <span style="background-color:#B0E0E6">augmented</span> by supplementation of TG cultures with <span style="background-color:#FFFF00">NGF</span> (Fig. 10A) or GDNF (Fig. 10B).  
+
| As in the case with <span style="background-color:#FFA07A">CAP</span>, the effects of AEA and ACEA on evoked <span style="background-color:#FFFF00">CGRP release</span> were <span style="background-color:#B0E0E6">augmented</span> by supplementation of <span style="background-color:#FFA07A">TG</span> cultures with <span style="background-color:#FFA07A">NGF</span> (Fig. 10A) or GDNF (Fig. 10B).  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NGF'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">augmented</span>) of <span style="color:#800000">'''CGRP release'''</span>
+
|  [[G:310738|<span style="color:#800000">'''NGF'''</span>]] [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">augmented</span>) of [[G:24241|<span style="color:#800000">'''CGRP release'''</span>]] associated with <span style="color:#FF0000">'''nerve growth factor'''</span>, <span style="color:#FF0000">'''qutenza'''</span>, <span style="color:#FF0000">'''trigeminal ganglion'''</span> and <span style="color:#FF0000">'''calcitonin gene-related peptide'''</span>
 
|-
 
|-
 
|}
 
|}
Line 421: Line 549:
 
! style="color: black; background:white; white-space:nowrap;"| 10)
 
! style="color: black; background:white; white-space:nowrap;"| 10)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.408151022306057
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.41
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2005
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2005|2005]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:BMC Neurosci|BMC Neurosci]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC548274 PMC548274]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC548274 PMC548274]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.28
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.27
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| <span style="background-color:#FFFF00">NGF</span> increases the expression of the pro-inflammatory neuropeptide CGRP [13] and <span style="background-color:#B0E0E6">increases</span> substance P (SP) and <span style="background-color:#FFFF00">CGRP</span> content in <span style="background-color:#FFDEAD">sensory neurons</span> [14-17].  
+
| <span style="background-color:#FFA07A">NGF</span> increases the expression of the pro-<span style="background-color:#FFA07A">inflammatory</span> <span style="background-color:#FFA07A">neuropeptide</span> <span style="background-color:#FFA07A">CGRP</span> [13] and <span style="background-color:#B0E0E6">increases</span> <span style="background-color:#FFA07A">substance P</span> (<span style="background-color:#FFA07A">SP</span>) and <span style="background-color:#FFFF00">CGRP</span> content in <span style="background-color:#FFDEAD">sensory neurons</span> [14-17].  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NGF'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">increases</span>) of <span style="color:#800000">'''CGRP'''</span> in <span style="color:#808000">sensory neurons</span>
+
|  [[G:310738|<span style="color:#800000">'''NGF'''</span>]] [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">increases</span>) of [[G:24241|<span style="color:#800000">'''CGRP'''</span>]] in [[A:sensory neurons|<span style="color:#808000">sensory neurons</span>]] associated with <span style="color:#FF0000">'''inflammation'''</span>, <span style="color:#FF0000">'''nerve growth factor'''</span>, <span style="color:#FF0000">'''neuropeptide'''</span>, <span style="color:#FF0000">'''substance p'''</span> and <span style="color:#FF0000">'''calcitonin gene-related peptide'''</span>
 
|-
 
|-
 
|}
 
|}
Line 448: Line 580:
 
! style="color: black; background:white; white-space:nowrap;"| 11)
 
! style="color: black; background:white; white-space:nowrap;"| 11)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.408151022306057
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.41
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2005
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2005|2005]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:BMC Neurosci|BMC Neurosci]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Body
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC548274 PMC548274]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=PMC548274 PMC548274]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.76
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 1.36
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| A second skin-derived factor <span style="background-color:#FFFF00">nerve growth factor</span> (NGF) also increased in wounded skin and <span style="background-color:#B0E0E6">increased</span> <span style="background-color:#FFFF00">CGRP</span> in cultured adult dorsal root ganglia (DRG) <span style="background-color:#FFDEAD">neurons</span> but with lower efficacy.  
+
| A second skin-derived factor <span style="background-color:#FFFF00">nerve growth factor</span> (NGF) also increased in wounded skin and <span style="background-color:#B0E0E6">increased</span> <span style="background-color:#FFA07A">CGRP</span> in cultured adult dorsal root ganglia (DRG) <span style="background-color:#FFDEAD">neurons</span> but with lower efficacy.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''nerve growth factor'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">increased</span>) of <span style="color:#800000">'''CGRP'''</span> in <span style="color:#808000">neurons</span>
+
|  [[G:310738|<span style="color:#800000">'''nerve growth factor'''</span>]] [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">increased</span>) of [[G:24241|<span style="color:#800000">'''CGRP'''</span>]] in [[A:neurons|<span style="color:#808000">neurons</span>]] associated with <span style="color:#FF0000">'''nerve growth factor'''</span> and <span style="color:#FF0000">'''calcitonin gene-related peptide'''</span>
 
|-
 
|-
 
|}
 
|}
Line 475: Line 611:
 
! style="color: black; background:white; white-space:nowrap;"| 12)
 
! style="color: black; background:white; white-space:nowrap;"| 12)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.105789350741744
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.11
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2004
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2004|2004]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Dev. Biol.|Dev. Biol.]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Abstract
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=15196945 15196945]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=15196945 15196945]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.42
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.49
 
|}
 
|}
 
|-
 
|-
 
|}
 
|}
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
 
{| style="color: black; background-color: white;" cellpadding=6 cellspacing=6 class="wikitable"
| A second skin-derived factor nerve growth factor (<span style="background-color:#FFFF00">NGF</span>) also increased in wounded skin and <span style="background-color:#B0E0E6">increased</span> <span style="background-color:#FFFF00">CGRP</span> in cultured adult dorsal root ganglia (DRG) <span style="background-color:#FFDEAD">neurons</span> but with lower efficacy.  
+
| A second skin-derived factor <span style="background-color:#FFA07A">nerve growth factor</span> (<span style="background-color:#FFFF00">NGF</span>) also increased in wounded skin and <span style="background-color:#B0E0E6">increased</span> <span style="background-color:#FFA07A">CGRP</span> in cultured adult dorsal root ganglia (DRG) <span style="background-color:#FFDEAD">neurons</span> but with lower efficacy.  
 
|-
 
|-
 
|
 
|
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
| <span style="color:#800000">'''NGF'''</span> <span style="color:#000080">'''Positive_regulation'''</span> (<span style="color:#000080">increased</span>) of <span style="color:#800000">'''CGRP'''</span> in <span style="color:#808000">neurons</span>
+
|  [[G:310738|<span style="color:#800000">'''NGF'''</span>]] [[E:Positive_regulation|<span style="color:#000080">'''Positive_regulation'''</span>]] (<span style="color:#000080">increased</span>) of [[G:24241|<span style="color:#800000">'''CGRP'''</span>]] in [[A:neurons|<span style="color:#808000">neurons</span>]] associated with <span style="color:#FF0000">'''nerve growth factor'''</span> and <span style="color:#FF0000">'''calcitonin gene-related peptide'''</span>
 
|-
 
|-
 
|}
 
|}
Line 502: Line 642:
 
! style="color: black; background:white; white-space:nowrap;"| 13)
 
! style="color: black; background:white; white-space:nowrap;"| 13)
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Confidence
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.105789350741744
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.11
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2004
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2004|2004]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Dev. Biol.|Dev. Biol.]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Section
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| N/A
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| Abstract
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Doc Link
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=15196945 15196945]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [http://www.ncbi.nlm.nih.gov/pubmed?term=15196945 15196945]
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Disease Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.42
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Pain Relevance
 +
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.49
 
|}
 
|}
 
|-
 
|-

Latest revision as of 23:36, 20 September 2012

Context Info
Confidence 0.76
First Reported 1997
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 13
Disease Relevance 2.98
Pain Relevance 12.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ngf, Calca) aging (Ngf, Calca) extracellular region (Ngf, Calca)
signal transduction (Ngf) nucleus (Calca) intracellular (Calca)
Anatomy Link Frequency
nerve 4
neurons 2
sensory neurons 1
outflow 1
Ngf (Rattus norvegicus)
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 647 100.00 Very High Very High Very High
Calcitonin gene-related peptide 614 100.00 Very High Very High Very High
trigeminal ganglion 354 100.00 Very High Very High Very High
Neuropeptide 106 100.00 Very High Very High Very High
substance P 60 100.00 Very High Very High Very High
Inflammation 36 100.00 Very High Very High Very High
qutenza 312 99.20 Very High Very High Very High
c fibre 11 98.84 Very High Very High Very High
agonist 36 96.88 Very High Very High Very High
Cannabinoid 12 96.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 438 100.00 Very High Very High Very High
Nociception 53 100.00 Very High Very High Very High
INFLAMMATION 30 100.00 Very High Very High Very High
Hyperalgesia 42 92.80 High High
Injury 150 89.28 High High
Pain 20 68.60 Quite High
Hypersensitivity 12 7.04 Low Low
Headache 36 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Nervous System Injury 12 5.00 Very Low Very Low Very Low

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the adult rat, nerve growth factor (NGF) upregulates the nociceptive peptide substance P (SP) and calcitonin gene-related peptide (CGRP) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.
NGF Positive_regulation (upregulates) of CGRP in nerve associated with nociception, c fibre, nerve growth factor, neuropeptide, calcitonin gene-related peptide and substance p
1) Confidence 0.76 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9182964 Disease Relevance 0.10 Pain Relevance 1.02
In the adult rat, nerve growth factor (NGF) upregulates the nociceptive peptide substance P (SP) and calcitonin gene-related peptide (CGRP) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.
nerve growth factor Positive_regulation (upregulates) of calcitonin gene-related peptide in nerve associated with nociception, c fibre, nerve growth factor, neuropeptide, calcitonin gene-related peptide and substance p
2) Confidence 0.76 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9182964 Disease Relevance 0.10 Pain Relevance 1.02
In the adult rat, nerve growth factor (NGF) upregulates the nociceptive peptide substance P (SP) and calcitonin gene-related peptide (CGRP) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.
NGF Positive_regulation (upregulates) of calcitonin gene-related peptide in nerve associated with nociception, c fibre, nerve growth factor, neuropeptide, calcitonin gene-related peptide and substance p
3) Confidence 0.76 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9182964 Disease Relevance 0.10 Pain Relevance 1.02
In the adult rat, nerve growth factor (NGF) upregulates the nociceptive peptide substance P (SP) and calcitonin gene-related peptide (CGRP) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.
nerve growth factor Positive_regulation (upregulates) of CGRP in nerve associated with nociception, c fibre, nerve growth factor, neuropeptide, calcitonin gene-related peptide and substance p
4) Confidence 0.76 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9182964 Disease Relevance 0.10 Pain Relevance 1.02
NGF (1.0 mg/kg s.c.) greatly increased basal and stimulus-evoked SP and CGRP release; at 0.1 mg/kg, NGF did not affect SP release but significantly increased CGRP basal outflow and evoked release.
NGF Neg (not) Positive_regulation (increased) of CGRP in outflow associated with nerve growth factor, calcitonin gene-related peptide and substance p
5) Confidence 0.66 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9182964 Disease Relevance 0.08 Pain Relevance 1.26
Much like K+-evoked CGRP release, total CGRP content was increased significantly by NGF and GDNF treatment, while BDNF had no effect (Fig. 6C).
NGF Positive_regulation (increased) of CGRP release associated with nerve growth factor and calcitonin gene-related peptide
6) Confidence 0.61 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 0.84
Much like K+-evoked CGRP release, total CGRP content was increased significantly by NGF and GDNF treatment, while BDNF had no effect (Fig. 6C).
NGF Positive_regulation (increased) of CGRP associated with nerve growth factor and calcitonin gene-related peptide
7) Confidence 0.61 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 0.83
Furthermore, NGF and GDNF increased the releasable pool and total content of CGRP while increasing TRPV1 protein, without increasing its mRNA.
NGF Positive_regulation (increased) of CGRP associated with nerve growth factor and calcitonin gene-related peptide
8) Confidence 0.44 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.62 Pain Relevance 1.35
Both NGF and GDNF increased CGRP content concentration-dependently at every concentration (p < 0.001), with peaks at 10 ng/ml (3.2-fold increase) for NGF and 100 ng/ml (3.0-fold increase) for GDNF (Fig. 6C).
NGF Positive_regulation (increased) of CGRP associated with nerve growth factor and calcitonin gene-related peptide
9) Confidence 0.44 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 0.80
As in the case with CAP, the effects of AEA and ACEA on evoked CGRP release were augmented by supplementation of TG cultures with NGF (Fig. 10A) or GDNF (Fig. 10B).
NGF Positive_regulation (augmented) of CGRP release associated with nerve growth factor, qutenza, trigeminal ganglion and calcitonin gene-related peptide
10) Confidence 0.41 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.28 Pain Relevance 1.27
NGF increases the expression of the pro-inflammatory neuropeptide CGRP [13] and increases substance P (SP) and CGRP content in sensory neurons [14-17].
NGF Positive_regulation (increases) of CGRP in sensory neurons associated with inflammation, nerve growth factor, neuropeptide, substance p and calcitonin gene-related peptide
11) Confidence 0.41 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.76 Pain Relevance 1.36
A second skin-derived factor nerve growth factor (NGF) also increased in wounded skin and increased CGRP in cultured adult dorsal root ganglia (DRG) neurons but with lower efficacy.
nerve growth factor Positive_regulation (increased) of CGRP in neurons associated with nerve growth factor and calcitonin gene-related peptide
12) Confidence 0.11 Published 2004 Journal Dev. Biol. Section Abstract Doc Link 15196945 Disease Relevance 0.42 Pain Relevance 0.49
A second skin-derived factor nerve growth factor (NGF) also increased in wounded skin and increased CGRP in cultured adult dorsal root ganglia (DRG) neurons but with lower efficacy.
NGF Positive_regulation (increased) of CGRP in neurons associated with nerve growth factor and calcitonin gene-related peptide
13) Confidence 0.11 Published 2004 Journal Dev. Biol. Section Abstract Doc Link 15196945 Disease Relevance 0.42 Pain Relevance 0.49

[edit] General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox