INT69886

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Context Info
Confidence 3.7858241800
First Reported 1997
Last Reported 2005
Negated 1
Speculated 0
Reported most in NULL
Documents 8
Total Number 13

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extracellular space (Ngf, Calca) aging (Ngf, Calca) extracellular region (Ngf, Calca)
signal transduction (Ngf) nucleus (Calca) intracellular (Calca)
Anatomy Mention Frequency
nerve 4
neurons 2
sensory neurons 1
outflow 1
Ngf (Rattus norvegicus)
Calca (Rattus norvegicus)

Sentences Mentioned In

Key: Protein Event Anatomy Negation Speculation Pain term
In the adult rat, nerve growth factor (NGF) upregulates the nociceptive peptide substance P (SP) and calcitonin gene-related peptide (CGRP) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.
NGF Positive_regulation (upregulates) of CGRP in nerve
1) Confidence 0.759575030260726 Published 1997 Journal N/A Section N/A Doc Link 9182964
In the adult rat, nerve growth factor (NGF) upregulates the nociceptive peptide substance P (SP) and calcitonin gene-related peptide (CGRP) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.
nerve growth factor Positive_regulation (upregulates) of calcitonin gene-related peptide in nerve
2) Confidence 0.759575030260726 Published 1997 Journal N/A Section N/A Doc Link 9182964
In the adult rat, nerve growth factor (NGF) upregulates the nociceptive peptide substance P (SP) and calcitonin gene-related peptide (CGRP) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.
NGF Positive_regulation (upregulates) of calcitonin gene-related peptide in nerve
3) Confidence 0.759575030260726 Published 1997 Journal N/A Section N/A Doc Link 9182964
In the adult rat, nerve growth factor (NGF) upregulates the nociceptive peptide substance P (SP) and calcitonin gene-related peptide (CGRP) in neuronal cell bodies of C fibres but the effects of NGF on release of these neuropeptides from the central afferent terminals have not been reported.
nerve growth factor Positive_regulation (upregulates) of CGRP in nerve
4) Confidence 0.759575030260726 Published 1997 Journal N/A Section N/A Doc Link 9182964
NGF (1.0 mg/kg s.c.) greatly increased basal and stimulus-evoked SP and CGRP release; at 0.1 mg/kg, NGF did not affect SP release but significantly increased CGRP basal outflow and evoked release.
NGF Neg (not) Positive_regulation (increased) of CGRP in outflow
5) Confidence 0.66233474860899 Published 1997 Journal N/A Section N/A Doc Link 9182964
Much like K+-evoked CGRP release, total CGRP content was increased significantly by NGF and GDNF treatment, while BDNF had no effect (Fig. 6C).
NGF Positive_regulation (increased) of CGRP release
6) Confidence 0.608426159345174 Published 2005 Journal N/A Section N/A Doc Link PMC548274
Much like K+-evoked CGRP release, total CGRP content was increased significantly by NGF and GDNF treatment, while BDNF had no effect (Fig. 6C).
NGF Positive_regulation (increased) of CGRP
7) Confidence 0.608426159345174 Published 2005 Journal N/A Section N/A Doc Link PMC548274
Furthermore, NGF and GDNF increased the releasable pool and total content of CGRP while increasing TRPV1 protein, without increasing its mRNA.
NGF Positive_regulation (increased) of CGRP
8) Confidence 0.439378192736025 Published 2005 Journal N/A Section N/A Doc Link PMC548274
Both NGF and GDNF increased CGRP content concentration-dependently at every concentration (p < 0.001), with peaks at 10 ng/ml (3.2-fold increase) for NGF and 100 ng/ml (3.0-fold increase) for GDNF (Fig. 6C).
NGF Positive_regulation (increased) of CGRP
9) Confidence 0.439378192736025 Published 2005 Journal N/A Section N/A Doc Link PMC548274
As in the case with CAP, the effects of AEA and ACEA on evoked CGRP release were augmented by supplementation of TG cultures with NGF (Fig. 10A) or GDNF (Fig. 10B).
NGF Positive_regulation (augmented) of CGRP release
10) Confidence 0.408151022306057 Published 2005 Journal N/A Section N/A Doc Link PMC548274
NGF increases the expression of the pro-inflammatory neuropeptide CGRP [13] and increases substance P (SP) and CGRP content in sensory neurons [14-17].
NGF Positive_regulation (increases) of CGRP in sensory neurons
11) Confidence 0.408151022306057 Published 2005 Journal N/A Section N/A Doc Link PMC548274
A second skin-derived factor nerve growth factor (NGF) also increased in wounded skin and increased CGRP in cultured adult dorsal root ganglia (DRG) neurons but with lower efficacy.
nerve growth factor Positive_regulation (increased) of CGRP in neurons
12) Confidence 0.105789350741744 Published 2004 Journal N/A Section N/A Doc Link 15196945
A second skin-derived factor nerve growth factor (NGF) also increased in wounded skin and increased CGRP in cultured adult dorsal root ganglia (DRG) neurons but with lower efficacy.
NGF Positive_regulation (increased) of CGRP in neurons
13) Confidence 0.105789350741744 Published 2004 Journal N/A Section N/A Doc Link 15196945

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