INT6991

Context Info Confidence 0.55 First Reported 1992 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 3.83 Pain Relevance 1.32

isomerase activity (Ptgds) transport (Ptgds) Golgi apparatus (Ptgds) endoplasmic reticulum (Ptgds) lipid metabolic process (Ptgds) cytoplasm (Ptgds)

Anatomy Link Frequency macrophages 1 fibroblasts 1 melanocytes 1 ARH-77 1 mast cell 1 Ptgds (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 156 98.40 dexamethasone 3 95.04 Inflammatory mediators 4 94.48 Inflammatory response 4 85.80 melanocortin 1 receptor 33 81.08 Analgesic 1 75.00 cytokine 8 44.80 COX-2 inhibitor 20 34.12 cINOD 9 14.80 corticosteroid 4 13.92

Disease Link Frequency Relevance Heat Crystal Associated Disease 60 99.62 INFLAMMATION 167 98.40 Pressure And Volume Under Development 2 95.68 Pleurisy 2 93.72 Endometriosis (extended) 1 91.56 Hypersensitivity 9 89.12 Targeted Disruption 3 87.88 Apoptosis 68 87.24 Reprotox - General 1 3 82.64 Arthus Reaction 1 79.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Injection of MSU crystals led to a decrease of endogenous PGD2 synthase, whereas intrapouch injection of fibroblasts overexpressing the enzyme resulted in decreased inflammation and expression of pro-inflammatory mediators.

Negative_regulation (decrease) of PGD2 in fibroblasts associated with inflammatory mediators, inflammation and crystal associated disease

1) Confidence 0.55 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 1.37 Pain Relevance 0.46

raises PGE2, but decreases PGD2, synthesis by zymosan-stimulated murine macrophages [37].

Negative_regulation (decreases) of PGD2 in macrophages

2) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.75 Pain Relevance 0.26

Magnolol was less potent on reducing PGD2 formation in rat mast cell than that of indomethacin.

Negative_regulation (reducing) of PGD2 in mast cell

3) Confidence 0.19 Published 1992 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1336574 Disease Relevance 0.41 Pain Relevance 0.20

For example, L-type prostaglandin D2 synthase (Ptgds) is expressed at high levels in pigment cells [68] and is repressed in Mc1re/Mc1re skin (current data, [49]); prostaglandin D2 and its derivatives could be one of several mediators released from Mc1r-competent melanocytes that facilitate or potentiate p53 phosphorylation in surrounding cells [69].

Negative_regulation (repressed) of L-type prostaglandin D2 synthase in melanocytes

4) Confidence 0.12 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.59 Pain Relevance 0.39

For example, treatment of the COX-2-overexpressing myeloma cell line ARH-77 with indomethacin led to the reduction of PGD2, PGE2, and PGF2?

Negative_regulation (reduction) of PGD2 in ARH-77

5) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.71 Pain Relevance 0

General Comments

This test has worked.