INT6992

Context Info Confidence 0.39 First Reported 1992 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.93 Pain Relevance 0.44

isomerase activity (Ptgds) transport (Ptgds) Golgi apparatus (Ptgds) endoplasmic reticulum (Ptgds) lipid metabolic process (Ptgds) cytoplasm (Ptgds)

Anatomy Link Frequency neutrophils 2 mast cell 2 Ptgds (Mus musculus)

Pain Link Frequency Relevance Heat dexamethasone 1 95.84 Inflammation 39 88.08 chemokine 17 85.32 Analgesic 1 75.00 cytokine 7 25.00 agonist 5 25.00 antagonist 6 5.00 withdrawal 3 5.00 aspirin 2 5.00 COX2 2 5.00

Disease Link Frequency Relevance Heat Pressure And Volume Under Development 2 95.68 INFLAMMATION 42 88.08 Arthus Reaction 1 79.84 Adhesions 16 71.28 Infection 3 57.16 Injury 4 56.64 Necrosis 2 25.00 Cancer 2 25.00 Targeted Disruption 2 5.00 Infarction 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This alternative lipid blocked interactions between PGD2 and its receptor on neutrophils, preventing the process of migration across the endothelial barrier.

Negative_regulation (blocked) of PGD2 Binding (interactions) of in neutrophils

1) Confidence 0.39 Published 2009 Journal PLoS Biology Section Abstract Doc Link PMC2718617 Disease Relevance 0.51 Pain Relevance 0.24

Magnolol was less potent on reducing PGD2 formation in rat mast cell than that of indomethacin.

Negative_regulation (reducing) of PGD2 Binding (formation) of in mast cell

2) Confidence 0.19 Published 1992 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1336574 Disease Relevance 0.41 Pain Relevance 0.20

General Comments

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