INT6994

Context Info Confidence 0.36 First Reported 1992 Last Reported 2009 Negated 1 Speculated 0 Reported most in Abstract Documents 15 Total Number 16 Disease Relevance 7.06 Pain Relevance 3.54

isomerase activity (Ptgds) transport (Ptgds) Golgi apparatus (Ptgds) endoplasmic reticulum (Ptgds) lipid metabolic process (Ptgds) cytoplasm (Ptgds)

Anatomy Link Frequency skin 1 neutrophils 1 ventral 1 mast cell 1 Ptgds (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 201 99.34 IPN 6 99.14 cINOD 29 98.92 chemokine 36 97.16 Inflammatory response 7 96.40 dexamethasone 2 95.84 Pain 18 93.84 aspirin 13 84.88 Spinal cord 2 81.20 cytokine 24 81.12

Disease Link Frequency Relevance Heat Asthma 1 99.80 INFLAMMATION 225 99.34 Pressure And Volume Under Development 4 95.32 Pain 16 93.84 Death 24 93.00 Disease 9 92.48 Hypersensitivity 7 92.16 Targeted Disruption 13 84.72 Aneurism 2 84.52 Apoptosis 48 84.44

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found the PGD2 receptors DP1 and chemoattractant receptor homologous molecule expressed on T helper type 2 cells (CRTH2) localized in neurons of the dorsal, and motoneurons in the ventral horn.

PGD2 Binding (found) of in ventral

1) Confidence 0.36 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18028337 Disease Relevance 0.28 Pain Relevance 0.32

This alternative lipid blocked interactions between PGD2 and its receptor on neutrophils, preventing the process of migration across the endothelial barrier.

PGD2 Binding (interactions) of in neutrophils

2) Confidence 0.32 Published 2009 Journal PLoS Biology Section Abstract Doc Link PMC2718617 Disease Relevance 0.51 Pain Relevance 0.24

Importantly, a number of studies have shown that the presence of PGD2 can in turn inhibit the ability of DCs to migrate out of the lungs or the skin during an inflammatory response, although the molecular mechanism by which this inhibition is achieved remains undescribed [35],[36].

PGD2 Binding (presence) of in skin associated with inflammatory response

3) Confidence 0.32 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0.10 Pain Relevance 0.17

Saturation ligand binding isotherms demonstrated high-affinity binding of [3H]PGD2, with a Kd of 8.8 +/- 0.8 nM.

PGD2 Binding (binding) of

4) Confidence 0.31 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721327 Disease Relevance 0.43 Pain Relevance 0.11

Competition binding assays with a panel unlabeled prostanoids demonstrated an order of affinity of 13,14-dihydro-15-keto-PGD2 (DK-PGD2) >or= 15-deoxy-Delta12,14-PGJ2 (15d-PGJ2) >or= PGD2 >or= PGJ2. [3H]PGD2 binding was also displaced by the nonsteroidal anti-inflammatory drug indomethacin, with a Ki value of 1.04 +/- 0.13 microM.

PGD2 Binding (binding) of associated with inflammation and cinod

5) Confidence 0.31 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721327 Disease Relevance 0.48 Pain Relevance 0.14

Indomethacin, sulindac sulfide, and zomepirac displaced [3H]PGD2 binding at the mouse CRTH2 receptor (mCRTH2) with comparable affinity (Ki = 1.5 +/- 0.1, 2.5 +/- 0.4, and 3.3 +/- 0.3 microM, respectively).

PGD2 Binding (binding) of

6) Confidence 0.30 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15563582 Disease Relevance 0.41 Pain Relevance 0.42

Although it is also involved in acute inflammatory states, such as asthma [31,32], PGD2 is now increasingly recognized as an important mediator of the resolution of inflammation.

PGD2 Binding (recognized) of associated with asthma and inflammation

7) Confidence 0.29 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 1.27 Pain Relevance 0.48

However, deletion of mPGES-1 permits rediversion of the PGH2 substrate to other PG synthases and augmented formation of PGI2 and PGD2 mitigates this effect.

PGD2 Binding (formation) of

8) Confidence 0.29 Published 2008 Journal J. Intern. Med. Section Abstract Doc Link 18410593 Disease Relevance 1.29 Pain Relevance 0.54

This chimeric IPN-V/DPVI-C receptor acquired the ability to bind [3H]PGD2 and [3H]PGE2 without decreasing the affinities of the mIP receptor to [3H]iloprost and [3H]PGE1.

PGD2 Binding (bind) of associated with ipn

9) Confidence 0.26 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9182536 Disease Relevance 0 Pain Relevance 0.18

The mDP receptor bound only [3H]PGD2 with a Kd value of 43 nM.

PGD2 Binding (bound) of

10) Confidence 0.26 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9182536 Disease Relevance 0 Pain Relevance 0.16

This receptor did not bind [3H]PGD2, [3H]PGE2, and [3H]PGF2alpha.

PGD2 Neg (not) Binding (bind) of

11) Confidence 0.26 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9182536 Disease Relevance 0 Pain Relevance 0.15

Magnolol was less potent on reducing PGD2 formation in rat mast cell than that of indomethacin.

PGD2 Binding (formation) of in mast cell

12) Confidence 0.16 Published 1992 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1336574 Disease Relevance 0.41 Pain Relevance 0.20

Four of these receptor subtypes bind PGE2 (EP1-EP4), two bind PGD2 (DP1 and DP2), and the other receptors bind PGF2, PGI2, and TxA2 (FP, IP, and TP) respectively (Narumiya et al. 1999; Breyer et al. 2001; Hirai et al. 2001).

PGD2 Binding (bind) of

13) Confidence 0.15 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.58 Pain Relevance 0.15

Prostanoids are lipid mediators generated from AA by the enzymatic action of the cyclooxygenases (COX) 1 and 2 to form the intermediate PGH2, with subsequent metabolism to specific prostanoid species (e.g., PGD2, PGE2, PGF2?

PGD2 Binding (metabolism) of

14) Confidence 0.12 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0.72 Pain Relevance 0.12

Four of these receptor subtypes bind PGE2 (EP1-EP4), two bind PGD2 (DP1 and DP2), and the other receptors bind PGF2, PGI2, and TxA2 (FP, IP, and TP) respectively (Narumiya et al. 1999; Breyer et al. 2001; Hirai et al. 2001).

PGD2 Binding (bind) of

15) Confidence 0.11 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.58 Pain Relevance 0.15

CONCLUSIONS: Our results confirm that the action of DA D2 and D3 receptors could be dependent on the dopaminergic state, in this case modified by the action of morphine.

DA D2 Binding (action) of

16) Confidence 0.08 Published 1999 Journal Psychopharmacology (Berl.) Section Body Doc Link 10227083 Disease Relevance 0 Pain Relevance 0

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