INT70050

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Context Info
Confidence 0.58
First Reported 1997
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 56
Total Number 57
Disease Relevance 37.45
Pain Relevance 12.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
plasma 6
blood 5
plaque 2
chondrocytes 1
cerebrospinal fluid 1
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1257 100.00 Very High Very High Very High
Inflammatory response 73 99.70 Very High Very High Very High
Osteoarthritis 180 99.64 Very High Very High Very High
Angina 10 99.28 Very High Very High Very High
rheumatoid arthritis 209 99.22 Very High Very High Very High
Neuritis 11 99.08 Very High Very High Very High
Inflammation 718 98.86 Very High Very High Very High
Adalimumab 217 98.66 Very High Very High Very High
anesthesia 26 98.44 Very High Very High Very High
fibrosis 8 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 861 100.00 Very High Very High Very High
Disease 446 99.98 Very High Very High Very High
Pneumonia 28 99.88 Very High Very High Very High
Psoriasis 47 99.84 Very High Very High Very High
Knee Osteoarthritis 145 99.64 Very High Very High Very High
Atherosclerotic Plaque 10 99.34 Very High Very High Very High
Granuloma 1 99.34 Very High Very High Very High
Cv General 3 Under Development 15 99.28 Very High Very High Very High
Renal Insufficiency 1 99.28 Very High Very High Very High
Rheumatoid Arthritis 212 99.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum levels of the antiinflammatory cytokine interleukin-10 are decreased in patients with unstable angina.
Negative_regulation (decreased) of antiinflammatory cytokine interleukin-10 associated with angina, inflammation and cytokine
1) Confidence 0.58 Published 2001 Journal Circulation Section Title Doc Link 11502695 Disease Relevance 0.48 Pain Relevance 0.33
A linear relationship between AUC and Clcr as well as Clp and Clcr demonstrates that the disposition of rHuIL-10 is altered in subjects with renal insufficiency.
Negative_regulation (altered) of rHuIL-10 associated with renal insufficiency
2) Confidence 0.43 Published 1999 Journal J Clin Pharmacol Section Abstract Doc Link 10516935 Disease Relevance 0.10 Pain Relevance 0
TEB was clinically effective and patients receiving TEB showed decreased circulating levels of IL-10.
Negative_regulation (decreased) of IL-10
3) Confidence 0.41 Published 2003 Journal Cytokine Section Abstract Doc Link 14609565 Disease Relevance 0.38 Pain Relevance 0.48
There is similar evidence that IL-10 has a beneficial role in human atherosclerotic plaques, [37,43-45] and serum levels of IL-10 are reduced in patients with unstable angina [46].
Negative_regulation (reduced) of IL-10 in plaques associated with atherosclerotic plaque and angina
4) Confidence 0.37 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868866 Disease Relevance 1.97 Pain Relevance 0.20
One study has, in support of our results, demonstrated that higher levels of regular physical activity are associated with increased levels of IL-10 in the blood of healthy older males, whereas studies on young, moderately and well-trained males in different training sessions have shown both increases as well as a decrease in serum IL-10 concentrations.
Negative_regulation (decrease) of IL-10 in blood
5) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945016 Disease Relevance 0.81 Pain Relevance 0.44
Following ESW application, while beta1 integrin expression remain unchanged, a significant decrease of IL-10 and TNF-alpha intracellular levels was observed both in osteoarthritic and healthy chondrocytes.
Negative_regulation (decrease) of IL-10 in chondrocytes associated with osteoarthritis
6) Confidence 0.33 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2268688 Disease Relevance 0.95 Pain Relevance 0.07
Additionally, it remains to be clarified whether IL-10 decrease is a specific outcome of ESW treatment or mediated by TNF-alpha reduction since it has been shown that TNF-alpha up-regulates IL-10 expression in rheumatoid arthritis synovitis [20].
Spec (whether) Negative_regulation (decrease) of IL-10 associated with synovitis and rheumatoid arthritis
7) Confidence 0.33 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.56 Pain Relevance 0.24
IL-10 levels decreased at any impulses and energy levels, while a significant reduction of TNF-alpha was mainly found at middle energies.


Negative_regulation (decreased) of IL-10
8) Confidence 0.33 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2268688 Disease Relevance 0.94 Pain Relevance 0.06
There was significant (P<0.005) downregulation of IL-10 in the responders of all the three groups 1-week after Fungisome treatment compared to before treatment (Table 3) and non-responders (P<0.05).
Negative_regulation (downregulation) of IL-10
9) Confidence 0.31 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.30 Pain Relevance 0.12
However, there was no significant downregulation of IL-10 in the non-responders who suffered relapse.
Neg (no) Negative_regulation (downregulation) of IL-10 associated with recurrence
10) Confidence 0.31 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.32 Pain Relevance 0.11
A significant downregulation of IL-12 and IL-10 in the plasma, elevation of IFN-?
Negative_regulation (downregulation) of IL-10 in plasma
11) Confidence 0.31 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.19 Pain Relevance 0.05
Patients who suffered relapse, showed neither significant elevation of Th1 cytokines nor downregulation of IL-10, at this time point, although TGF-?
Negative_regulation (downregulation) of IL-10 associated with recurrence and cytokine
12) Confidence 0.31 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.57 Pain Relevance 0.22
This differential immune response 1 week posttreatment between the responder and non-responder patients further substantiates the significance of upregulation of Th1 cytokines and simultaneous downregulation of IL-10 for the success of therapy.
Negative_regulation (downregulation) of IL-10 associated with cytokine
13) Confidence 0.31 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.48 Pain Relevance 0.22
were elevated during active disease (Table 2). 1-week after treatment, there was significant downregulation of IL-12 and IL-10 (P<0.005) in the responders compared to untreated condition, however, there was no significant change in the levels of IFN-?
Negative_regulation (downregulation) of IL-10 associated with disease
14) Confidence 0.31 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.53 Pain Relevance 0.17
Simultaneous downregulation of IL-10 and TGF-?
Negative_regulation (downregulation) of IL-10
15) Confidence 0.31 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.15 Pain Relevance 0.09
In addition, our previous study revealed that AmB can downregulate IL-10 and TGF-?
Negative_regulation (downregulate) of IL-10
16) Confidence 0.31 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.16 Pain Relevance 0.09
Its immunosuppressive effect was further demonstrated by inhibition of interleukin-9 (IL-9), IL-10 but failed to influence IL-2, IL-15 and interferon-y (IFN-gamma) in PPD stimulated human PBMCs.
Negative_regulation (inhibition) of IL-10
17) Confidence 0.29 Published 2002 Journal Int. Immunopharmacol. Section Abstract Doc Link 12095165 Disease Relevance 0.08 Pain Relevance 0.37
An observation that contrasts with the finding that children with MOD had reduced IL-10 serum levels [23] prior to CPB.
Negative_regulation (reduced) of IL-10
18) Confidence 0.29 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 1.05 Pain Relevance 0.07
Following ESW treatment IL-10 levels significantly decreased both in OA (A1 33.9 ± 23, A2 32 ± 22, B1 32.5 ± 25, B2 32.9 ± 22) and normal cartilage (A1 15.2 ± 8, A2 10.5 ± 12, B1 14.5 ± 6), except for the strongest ESW application (B2 21 ± 9).


Negative_regulation (decreased) of IL-10 in cartilage associated with osteoarthritis
19) Confidence 0.29 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.62 Pain Relevance 0.28
Nevertheless, a proinflammatory haplotype of SNPs in IL-6, IL-10, and TNF-?
Negative_regulation (haplotype) of IL-10
20) Confidence 0.27 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868866 Disease Relevance 1.29 Pain Relevance 0.44

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