INT70227

Context Info Confidence 0.36 First Reported 1997 Last Reported 1997 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.35 Pain Relevance 0.42

extracellular space (Calca) aging (Calca) extracellular region (Calca) Golgi apparatus (B3GAT1) nucleus (Calca) intracellular (Calca)

Anatomy Link Frequency vasculature 1 Calca (Rattus norvegicus) B3GAT1 (Homo sapiens)

Pain Link Frequency Relevance Heat substance P 2 99.54 Migraine 1 98.52 agonist 2 88.88 antagonist 3 82.44 Calcitonin gene-related peptide 1 75.00

Disease Link Frequency Relevance Heat Headache 1 98.52 Increased Venous Pressure Under Development 2 96.82 Cerebral Edema 1 66.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In humans, vasodilation within the meningeal vasculature has been implicated in the pathogenesis of migraine, the present experiments indicate that substance P or neurokinin A (both acting through NK1 receptors) or CGRP may be responsible.

CGRP Binding (acting) of NK1 in vasculature associated with migraine, increased venous pressure under development and substance p

1) Confidence 0.36 Published 1997 Journal Cephalalgia Section Abstract Doc Link 9209773 Disease Relevance 0.35 Pain Relevance 0.42

General Comments

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