INT70303

From wiki-pain
Revision as of 22:16, 22 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.52
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 19
Total Number 21
Disease Relevance 12.90
Pain Relevance 8.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
lymph nodes 1
plasma 1
epithelial cell 1
blood 1
monocytes 1
Il4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 196 100.00 Very High Very High Very High
Inflammation 200 99.98 Very High Very High Very High
ketamine 278 99.60 Very High Very High Very High
Migraine 20 98.96 Very High Very High Very High
Neuritis 19 98.68 Very High Very High Very High
cva 12 98.40 Very High Very High Very High
Substantia nigra 45 96.56 Very High Very High Very High
Sciatic nerve 2 94.16 High High
aspirin 8 94.08 High High
depression 5 93.04 High High
Disease Link Frequency Relevance Heat
Cancer 56 100.00 Very High Very High Very High
Adhesions 9 100.00 Very High Very High Very High
Necrosis 7 100.00 Very High Very High Very High
INFLAMMATION 216 99.98 Very High Very High Very High
Immunization 3 99.70 Very High Very High Very High
Apoptosis 24 99.50 Very High Very High Very High
Schizophrenia 220 99.32 Very High Very High Very High
Headache 21 98.96 Very High Very High Very High
Experimental Autoimmune Neuritis 9 98.68 Very High Very High Very High
Cv General 3 Under Development 10 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of antiulcer agents, indomethacin caused multiple hemorrhagic lesions and extensive epithelial cell apoptosis, accompanied by a 20.7% reduction in IL-4, a 3.1-fold increase in mucosal expression of ET-1 and a 4.2-fold decline in cNOS.
Negative_regulation (reduction) of IL-4 in epithelial cell associated with apoptosis
1) Confidence 0.52 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10424717 Disease Relevance 0.61 Pain Relevance 0.11
The results suggest that an increase in vasoconstrictive ET-1 level combined with a decrease in regulatory cytokine, IL-4, and a loss of compensatory action by cNOS may be responsible for gastric mucosal injury caused by indomethacin.
Negative_regulation (decrease) of IL-4 associated with injury and cytokine
2) Confidence 0.38 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10424717 Disease Relevance 0.52 Pain Relevance 0.16
Our results revealed that delivery of aerosolized ketamine using an ultrasonic nebulizer markedly suppressed allergen-mediated airway hyperreactivity, airway inflammation and airway inflammatory cell infiltration into the BALF, and significantly decreased the levels of interleukin-4 (IL-4) in the BALF and expression of iNOS and the concentration of NO in the inflamed airways from OVA-treated rats.
Negative_regulation (decreased) of interleukin-4 associated with asthma, inflammation and ketamine
3) Confidence 0.27 Published 2007 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1876456 Disease Relevance 0.75 Pain Relevance 0.60
-injected ketamine showed significant decreases in IL-4 protein levels compared to OVA control animals (121.30 ± 11.18 pg/ml, P = 0.036; 119.33 ± 14.60 pg/ml, P = 0.041; 108.60 ± 9.34, P = 0.016, respectively).
Negative_regulation (decreases) of IL-4 associated with ketamine
4) Confidence 0.27 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 0.19 Pain Relevance 0.51
and decrease in the levels of IL-4 and IL-10.
Negative_regulation (decrease) of IL-4
5) Confidence 0.23 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC3004822 Disease Relevance 0.80 Pain Relevance 0.13
There was a notable decrease in levels of IL-4 (63.8 ± 11.1 pg/mL vs. 105.9 ± 24.2 pg/mL) and IL-10 (462.4 ± 31.2 pg/mL vs. 979.5 ± 150.3 pg/mL).
Negative_regulation (decrease) of IL-4
6) Confidence 0.23 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004822 Disease Relevance 0.39 Pain Relevance 0.14
VPA (300 mg/kg, intraperitoneally) administration to EAN rats once daily immediately following immunization significantly suppressed mRNA levels of interferon-gamma, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-4, IL-6 and IL-17 in the lymph nodes of EAN rats.
Negative_regulation (suppressed) of IL-4 in lymph nodes associated with necrosis, cancer, immunization and neuritis
7) Confidence 0.21 Published 2008 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 18953683 Disease Relevance 1.37 Pain Relevance 1.01
IL-4 decreased significantly in "Shenyang" prescription group I than group II (P < 0.05).
Negative_regulation (decreased) of IL-4
8) Confidence 0.15 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.43 Pain Relevance 0.11
[t(11) = 6.25, p < 0.001] and MCP-1 [t(11) = 2.57, p < 0.05) and a significant decrease in IL-4 [t(11) = 3.15, p < 0.01] compared to saline controls.
Negative_regulation (decrease) of IL-4
9) Confidence 0.07 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2292163 Disease Relevance 0.07 Pain Relevance 0.73
In addition, our results indicate that experimental migraine crisis, induced by an NO donor, is mediated by the inhibition of IL-4 and subsequently of ICAM-1.
Negative_regulation (inhibition) of IL-4 associated with migraine
10) Confidence 0.06 Published 1997 Journal J. Mol. Med. Section Abstract Doc Link 9231885 Disease Relevance 0.89 Pain Relevance 0.80
Suplatast tosilate, which exerts its anti-inflammatory effect by suppressing IL-4 and IL-5 was given to patients with mild asthma for 6 weeks.
Negative_regulation (suppressing) of IL-4 associated with asthma and inflammation
11) Confidence 0.06 Published 1996 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 9216184 Disease Relevance 0.79 Pain Relevance 0.27
Inhibition of intercellular adhesion molecule-1 (ICAM-1), soluble ICAM-1 and interleukin-4 by nitric oxide expression in migraine patients.
Negative_regulation (Inhibition) of interleukin-4 associated with migraine and adhesions
12) Confidence 0.04 Published 1997 Journal J. Mol. Med. Section Title Doc Link 9231885 Disease Relevance 1.03 Pain Relevance 0.70
Immune hypotheses have been proposed for schizophrenia,287–289 and genetic studies have identified IL-2 and IL-4 polymorphisms as candidate genes in schizophrenia.290 A correlation between schizophrenia and autoimmune diseases is well known.291
Negative_regulation (identified) of IL-4 associated with autoimmune disease and schizophrenia
13) Confidence 0.04 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.07 Pain Relevance 0.07
Significant reduced plasma levels (P < .01) of TNF-alpha, IL-4, IL-6 and IgE were observed in the patients treated with YS-Tang.
Negative_regulation (reduced) of IL-4 in plasma
14) Confidence 0.03 Published 2002 Journal Vascul. Pharmacol. Section Abstract Doc Link 12616992 Disease Relevance 0.93 Pain Relevance 0.61
In this study, we provide evidence that NCX-4016 delivered to PMBC-derived T lymphocytes and monocytes causes a transitory inhibition of cell respiration and approximately 50% reduction of cellular ATP, which translates in a time-reversible inhibition of cell proliferation and IL-2, IL-4, IL-5, and IFN-gamma secretion.
Negative_regulation (inhibition) of IL-4 in monocytes
15) Confidence 0.02 Published 2004 Journal J. Immunol. Section Abstract Doc Link 15240674 Disease Relevance 0.07 Pain Relevance 0.28
To study a possible relation between cytokine profiles and presence versus absence of MS-like brain MRI lesions and CSF OB, we used in situ hybridization to examine mRNA expression of the proinflammatory interleukin-12 (IL-12), interferon-gamma, and tumor necrosis factor-alpha and the immune response downregulating IL-10, transforming growth factor-beta, and IL-4 in blood and CSF mononuclear cells (MNC) from 59 patients with untreated ON.
Negative_regulation (downregulating) of IL-4 in mononuclear cells associated with necrosis, cancer, neuritis and cytokine
16) Confidence 0.02 Published 1998 Journal Neurology Section Abstract Doc Link 9443483 Disease Relevance 0.90 Pain Relevance 0.78
The mRNA for the anti-inflammatory cytokines IL-4 and IL-10 was reduced in the patient group (p=0.004; p=0.006), whereas TGF beta 1 mRNA levels did not differ between groups.
Negative_regulation (reduced) of cytokines IL-4 associated with inflammation and cytokine
17) Confidence 0.02 Published 2007 Journal Pain Section Abstract Doc Link 17890011 Disease Relevance 1.52 Pain Relevance 0.93
EA treatment also restored the balance between Th1 and Th2 systems by increasing TNF-alpha and decreasing IL-4.


Negative_regulation (decreasing) of IL-4
18) Confidence 0.02 Published 2009 Journal Pharmacopsychiatry Section Body Doc Link 19724980 Disease Relevance 0 Pain Relevance 0
IL-2, IL-4, IFN, TNF, perforin, granzyme B (GrB), and FasL mRNA expression levels were determined in peripheral blood mononuclear cells by competitive RT-PCR.
Spec (determined) Negative_regulation (determined) of IL-4 in blood
19) Confidence 0.01 Published 2002 Journal Blood Cells Mol. Dis. Section Abstract Doc Link 12490285 Disease Relevance 0.36 Pain Relevance 0.23
PN is associated with a rapid fall in lymphocyte cell counts and a change in cell profiles in gut-associated lymphoid tissue; this profile change is related to decreased levels of the Th2 cytokines IL-4 and IL-10 [23].
Negative_regulation (decreased) of Th2 cytokines IL-4 in lymphoid tissue associated with cytokine
20) Confidence 0.01 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.12 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox