INT7033

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Context Info
Confidence 0.37
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 6.66
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FSHR) plasma membrane (FSHR) signal transducer activity (FSHR)
Anatomy Link Frequency
follicle 7
urine 2
pituitary 1
FSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 78 100.00 Very High Very High Very High
Endogenous opioid 3 99.64 Very High Very High Very High
narcan 10 99.24 Very High Very High Very High
Dopamine 3 99.08 Very High Very High Very High
opiate 2 98.96 Very High Very High Very High
antagonist 53 98.76 Very High Very High Very High
Catecholamine 1 98.30 Very High Very High Very High
alcohol 7 90.36 High High
dexamethasone 7 88.52 High High
Opioid 17 87.12 High High
Disease Link Frequency Relevance Heat
Reprotox - General 1 139 98.56 Very High Very High Very High
Stress 13 97.66 Very High Very High Very High
Hypogonadotropic Hypogonadism 74 97.60 Very High Very High Very High
Endocrine Disease 1 96.28 Very High Very High Very High
Galactorrhea 38 92.88 High High
Reprotox - General 3 111 92.56 High High
Alcohol Addiction 4 90.60 High High
Ovarian Hyperstimulation Syndrome 30 89.60 High High
Klinefelter Syndrome 2 88.04 High High
Infection 5 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Follicle stimulating hormone (FSH) has been widely employed for ovulation induction and in-vitro fertilization.
Follicle stimulating hormone Binding (employed) of in Follicle
1) Confidence 0.37 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0
Follicle stimulating hormone (FSH) has been widely employed for ovulation induction and in-vitro fertilization.
FSH Binding (employed) of in Follicle
2) Confidence 0.37 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0
This ELISA is based on the dissociation of the FSH heterodimer in urine and the subsequent measurement of the beta subunit as a representation of total urinary FSH.
FSH Binding (dissociation) of in urine
3) Confidence 0.36 Published 1999 Journal Am. J. Primatol. Section Abstract Doc Link 10333433 Disease Relevance 0.17 Pain Relevance 0
We identified 9 relevant randomized controlled trials that compared recombinant FSH with urinary gonadotropins.25–33 One trial was excluded as it studied differential effects on hemostasis.32 A further 2 trials were excluded as pregnancy results after 1 treatment cycle could not be extracted.29,33 Two trials reported the data of 3 treatment cycles, without reporting the results of the first treatment cycle.29,33
FSH Binding (recombinant) of
4) Confidence 0.34 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.21 Pain Relevance 0
They possess similar alpha but different specific beta subunits.18,19 The nomenclature “alpha” differentiates it from another recombinant human FSH product which was marketed later as follitropin beta.20

Isoforms

FSH product Binding (recombinant) of
5) Confidence 0.25 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0 Pain Relevance 0
Later Noci et al. [20] updated their findings on 249 IVF cycles, when GnRH agonist desensitisation was used and stimulation with HP-FSH.
FSH Binding (findings) of associated with agonist
6) Confidence 0.24 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1947995 Disease Relevance 0 Pain Relevance 0.11
Letrozole-FSH and tamoxifen-alone stimulation were associated with significantly lower peak estradiol levels than tamoxifen-FSH stimulation.
Letrozole-FSH Binding (associated) of
7) Confidence 0.21 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397531 Disease Relevance 0.56 Pain Relevance 0.05
The receptors for the glycoprotein hormones thyroid-stimulating hormone (TSH), luteinizing hormone (LSH) and follicle-stimulating hormone (FSH) make up Group A10.
FSH Binding (receptors) of in follicle
8) Confidence 0.16 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.04
The receptors for the glycoprotein hormones thyroid-stimulating hormone (TSH), luteinizing hormone (LSH) and follicle-stimulating hormone (FSH) make up Group A10.
follicle-stimulating hormone Binding (receptors) of in follicle
9) Confidence 0.16 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.04
Recombinant FSH
FSH Binding (Recombinant) of
10) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.25 Pain Relevance 0.05
Stress hormones such as catecholamines (adrenalin, nonadrenaline and dopamine) and the hypothalamic-pituitary-adrenal axis interact with hormones which are responsible for normal ovulatory cycles: i.e., gonadotropin releasing hormone (GnRH), prolactin, LH and FSH.
FSH Binding (interact) of in pituitary associated with stress, dopamine and catecholamine
11) Confidence 0.12 Published 1992 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 1618356 Disease Relevance 1.39 Pain Relevance 0.20
It is also associated with low or low-normal FSH and LH levels.
FSH Binding (associated) of
12) Confidence 0.12 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 1.82 Pain Relevance 0.05
Oestradiol, follicle-stimulating hormone, luteinizing hormone and tyrosine kinase activity
follicle-stimulating hormone Binding (activity) of in follicle
13) Confidence 0.11 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400670 Disease Relevance 0.13 Pain Relevance 0
At the completion of the urine collection, participants had blood drawn for calcium, phosphorus, parathyroid hormone (PTH), parathyroid related protein (PTH-rP), 1,25-(OH)2 vitamin D, albumin, bone specific alkaline phosphatase, estradiol, luteinizing hormone (LH) and follicle stimulating hormone (FSH).
FSH Binding (drawn) of in urine
14) Confidence 0.09 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1950489 Disease Relevance 0.44 Pain Relevance 0
Commercial kits for radioimmunoassay were used to determine the serum concentrations of testosterone (Medgenics Diagnostics, Fleurus, Belgium); commercial kits for immuradiometric assays were used for determinations of LH and FSH (Medgenics Diagnostics).
FSH Binding (determinations) of
15) Confidence 0.05 Published 2006 Journal BMC Urol Section Body Doc Link PMC1444919 Disease Relevance 0.21 Pain Relevance 0
Deletion analysis identified a 358 bp fragment as the primary hormone-responsive sequence (-1858 to -1500 bp; containing three potential cAMP-responsive elements); its deletion resulted in severely reduced FSH responsiveness, and its ligation to hormone-unresponsive basal promoter sequences completely restored FSH responsiveness.
FSH Binding (ligation) of
16) Confidence 0.03 Published 1992 Journal Mol. Endocrinol. Section Abstract Doc Link 1337148 Disease Relevance 0 Pain Relevance 0
Hormonal assay: FSH, LH, Testosterone, TSH and Prolactin (for male with abnormal seminal analysis and suspected endocrine disorder)
FSH Binding (assay) of associated with endocrine disease
17) Confidence 0.03 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2844387 Disease Relevance 1.30 Pain Relevance 0.13
Sera were assayed for luteinizing hormone (LH), follicle-stimulating hormone (FSH) and cortisol by RIA.
follicle-stimulating hormone Binding (assayed) of in follicle
18) Confidence 0.03 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2498756 Disease Relevance 0 Pain Relevance 0.29
Modulation of luteinizing hormone and follicle-stimulating hormone in circulation by interactions between endogenous opioids and oestradiol during the peripubertal period of heifers.
follicle-stimulating hormone Binding (interactions) of in follicle associated with narcan and endogenous opioid
19) Confidence 0.03 Published 1992 Journal J. Reprod. Fertil. Section Title Doc Link 1432947 Disease Relevance 0.17 Pain Relevance 0.58

General Comments

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