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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2011
Negated 2
Speculated 6
Reported most in Abstract
Documents 118
Total Number 124
Disease Relevance 112.33
Pain Relevance 19.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (FAS) protein complex assembly (FAS) cytoplasm (FAS)
signal transducer activity (FAS) cytosol (FAS) signal transduction (FAS)
Anatomy Link Frequency
T cells 13
plaques 4
neuronal precursors 3
lymphocytes 3
endothelial cells 3
FAS (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 214 99.92 Very High Very High Very High
Morphine 64 99.82 Very High Very High Very High
fibrosis 109 99.36 Very High Very High Very High
cytokine 1122 99.16 Very High Very High Very High
Inflammation 1109 99.12 Very High Very High Very High
Inflammatory response 84 99.04 Very High Very High Very High
Endogenous opioid 5 99.04 Very High Very High Very High
Arthritis 284 98.80 Very High Very High Very High
rheumatoid arthritis 438 98.72 Very High Very High Very High
Inflammatory stimuli 48 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 2799 100.00 Very High Very High Very High
Cancer 2291 100.00 Very High Very High Very High
Death 641 100.00 Very High Very High Very High
Necrosis 190 100.00 Very High Very High Very High
Adhesions 141 100.00 Very High Very High Very High
Syndrome 119 100.00 Very High Very High Very High
Chorioamnionitis 330 99.92 Very High Very High Very High
Endometriosis 263 99.92 Very High Very High Very High
Coronary Artery Disease 101 99.76 Very High Very High Very High
Hypothermia 91 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fas and Ley were expressed randomly across a wide range in both the eutopic and ectopic endometrial tissues.
Gene_expression (expressed) of Fas
1) Confidence 0.75 Published 1996 Journal Mol. Hum. Reprod. Section Abstract Doc Link 9238697 Disease Relevance 1.43 Pain Relevance 0.50
After 24 weeks, a decrease in the number of mast cells and the enhanced expression of Fas antigen by lesional fibroblasts were observed.
Gene_expression (expression) of Fas in mast cells
2) Confidence 0.75 Published 2003 Journal J Dermatolog Treat Section Abstract Doc Link 14660274 Disease Relevance 1.13 Pain Relevance 0.45
Whereas treatment with R-flurbiprofen or ibuprofen resulted in a massive induction of p75(NTR) protein levels, the expression of Fas, p55(TNFR), DR3, DR4, DR5, and DR6 remained largely unchanged.
Gene_expression (expression) of Fas
3) Confidence 0.75 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409433 Disease Relevance 0.76 Pain Relevance 0.34
Resistance to apoptosis in CD28- T cells is due to elevated expression of antiapoptotic protein Bcl-2 and Fas-associated with death domain-like IL-1-converting enzyme inhibitory protein (FLIP) [16].
Gene_expression (expression) of Fas in T cells associated with apoptosis and death
4) Confidence 0.75 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165060 Disease Relevance 0.63 Pain Relevance 0.13
We identified, in fact, two independent tumors, with different localization and sharing some common features, markers of a highly aggressive potential: loss of cell differentiation markers and cell cycle regulators, ability to avoid death by suppressing Fas antigen expression and important invasive capacity by down regulation of E-cadherin expression.
Gene_expression (expression) of Fas associated with cancer and death
5) Confidence 0.75 Published 2010 Journal Rom J Morphol Embryol Section Abstract Doc Link 20191142 Disease Relevance 0.97 Pain Relevance 0.07
However, only in the posterior tumor, we found cells with high proliferation rate, Fas ligand molecule expression and MMP-9 secretion, acquisitions associated with a much more aggressive behavior.
Gene_expression (expression) of Fas in posterior associated with cancer and aggression
6) Confidence 0.75 Published 2010 Journal Rom J Morphol Embryol Section Abstract Doc Link 20191142 Disease Relevance 1.07 Pain Relevance 0.07
Notably, ATM activation was also found to control upregulation of Fas/CD95 expression and its co-clustering with TRPV1 as well as RT4 cell growth and apoptosis.
Gene_expression (expression) of CD95 in RT4 associated with apoptosis
7) Confidence 0.75 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19502594 Disease Relevance 0.88 Pain Relevance 0.48
Notably, ATM activation was also found to control upregulation of Fas/CD95 expression and its co-clustering with TRPV1 as well as RT4 cell growth and apoptosis.
Gene_expression (expression) of Fas in RT4 associated with apoptosis
8) Confidence 0.75 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19502594 Disease Relevance 0.88 Pain Relevance 0.48
In addition, combination treatment with As2O3 and sulindac increased the catalytic activity of caspase-3, -8, and -9 along with induction of Fas/FasL expression and cytosolic release of cytochrome c.
Gene_expression (expression) of Fas
9) Confidence 0.75 Published 2006 Journal Int. J. Oncol. Section Abstract Doc Link 16685442 Disease Relevance 0.56 Pain Relevance 0.15
We also investigated the number of mast cells and Fas antigen expression in the lesional skin (one patient) before and after treatment.
Gene_expression (expression) of Fas in skin
10) Confidence 0.75 Published 2003 Journal J Dermatolog Treat Section Abstract Doc Link 14660274 Disease Relevance 1.23 Pain Relevance 0.46
Interestingly, the effect of endogenous opioids was found to be exerted through increasing the expression of a cell death receptor, Fas, and an increased sensitivity of lymphocytes to apoptosis.
Gene_expression (expression) of Fas in lymphocytes associated with endogenous opioid, apoptosis and death
11) Confidence 0.75 Published 2003 Journal Brain Behav. Immun. Section Abstract Doc Link 12615182 Disease Relevance 0.94 Pain Relevance 0.27
We found a highly significant correlation of TNF-alpha and IFN-gamma production with activity and grade of gastritis (P < 0.01), H. pylori density (P = 0.01), epithelial cell apoptosis (P < 0.001), and Fas/Fas-ligand expression (P < 0.001).
Gene_expression (expression) of Fas in epithelial cell associated with apoptosis and gastritis
12) Confidence 0.75 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12121897 Disease Relevance 1.12 Pain Relevance 0.20
Because the cells of the anterior eye express Fas-ligand, infiltrating cells are apoptotically killed.
Gene_expression (express) of Fas in eye
13) Confidence 0.75 Published 1998 Journal Curr Opin Rheumatol Section Abstract Doc Link 9725092 Disease Relevance 0.84 Pain Relevance 0.19
Furthermore, the levels of TNF-alpha receptor R1 (TNF-R1, p55), bcl-2, soluble Fas (sFas), and the activities of caspase-1 and caspase-3 were also elevated in the nigrostriatal DA regions in PD.
Gene_expression (levels) of Fas associated with dopamine and disease
14) Confidence 0.75 Published 2000 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 11205147 Disease Relevance 1.14 Pain Relevance 0.61
Furthermore, RT-PCR analysis revealed that morphine and LPS up-regulated Fas expression.
Gene_expression (expression) of Fas associated with morphine
15) Confidence 0.74 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14698842 Disease Relevance 0.34 Pain Relevance 0.61
In contrast, short time immunohistochemical evaluation showed that the CD95 protein was strongly expressed in PT and PN, but not in PDC.
Neg (not) Gene_expression (expressed) of CD95
16) Confidence 0.65 Published 2002 Journal Pathol. Int. Section Abstract Doc Link 11940212 Disease Relevance 0.54 Pain Relevance 0.07
Reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed that CD97, CD95 and Fas-L mRNA were expressed on a similarly high level in all tissues.
Gene_expression (expressed) of CD95
17) Confidence 0.65 Published 2002 Journal Pathol. Int. Section Abstract Doc Link 11940212 Disease Relevance 0.57 Pain Relevance 0.07
This study investigated the mRNA and protein expression of CD97, CD95 and Fas-L in snap-frozen material obtained from human pancreatic ductal adenocarcinomas (PDC; n = 50), tissues from pancreatitis (PT; n = 40) and normal pancreatic tissues (PN; n = 36).
Gene_expression (expression) of CD95 associated with adenocarcinoma and pancreatitis
18) Confidence 0.65 Published 2002 Journal Pathol. Int. Section Abstract Doc Link 11940212 Disease Relevance 0.61 Pain Relevance 0.07
Sentrin interferes with Fas-induced as well as TNF-induced apoptosis, and was shown to be highly expressed in RASFs at sites of synovial invasion [67].
Gene_expression (expressed) of Fas associated with apoptosis
19) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 1.07 Pain Relevance 0.07
These include, the prominence of the PI3K/PTEN/Akt cell survival pathway [113, 114], upregulation of HSP70 gene expression [115], suppressed Fas/CD95-mediated signaling [116], activation of NF-?
Gene_expression (suppressed) of Fas
20) Confidence 0.65 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.38 Pain Relevance 0.42

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