INT70619

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Context Info
Confidence 0.60
First Reported 1997
Last Reported 2010
Negated 0
Speculated 5
Reported most in Abstract
Documents 6
Total Number 11
Disease Relevance 3.10
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Bmp2) growth (Bmp2) extracellular region (Bmp2)
embryo development (Bmp2) protein complex (Bmp2) cytoplasm (Bmp2)
Anatomy Link Frequency
SFs 3
mandible 1
stromal cells 1
astrocyte 1
Bmp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 3 98.52 Very High Very High Very High
Myofascial pain syndrome 3 96.68 Very High Very High Very High
Snapping jaw 3 95.40 Very High Very High Very High
Inflammation 18 93.04 High High
Pain 1 90.72 High High
glial activation 1 89.04 High High
cytokine 9 84.64 Quite High
anesthesia 5 83.44 Quite High
Central nervous system 6 77.56 Quite High
Inflammatory response 3 58.12 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 47 99.50 Very High Very High Very High
Osteoarthritis 3 98.52 Very High Very High Very High
Wound Healing 8 98.48 Very High Very High Very High
Rheumatic Diseases 3 97.76 Very High Very High Very High
Temporomandibular Joint Disorders 3 96.68 Very High Very High Very High
Temporomandibular Joint Syndrome 3 95.40 Very High Very High Very High
Disease 36 95.24 Very High Very High Very High
Arthritis 3 94.88 High High
INFLAMMATION 24 93.04 High High
Pain 1 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this study was to investigate the effects of recombinant human bone morphogenetic protein 2 (rhBMP-2) on an early stage of post-operative wound healing and following complete healing (10 and 38 days, respectively) in a rat model of periodontal regeneration.
Spec (investigate) Regulation (effects) of bone morphogenetic protein 2 associated with wound healing
1) Confidence 0.60 Published 1997 Journal J. Dent. Res. Section Abstract Doc Link 9240382 Disease Relevance 0.27 Pain Relevance 0.07
The aim of this study was to investigate the effects of recombinant human bone morphogenetic protein 2 (rhBMP-2) on an early stage of post-operative wound healing and following complete healing (10 and 38 days, respectively) in a rat model of periodontal regeneration.
Spec (investigate) Regulation (effects) of rhBMP-2 associated with wound healing
2) Confidence 0.52 Published 1997 Journal J. Dent. Res. Section Abstract Doc Link 9240382 Disease Relevance 0.27 Pain Relevance 0.07
Effects of hydrostatic pressure on cytoskeleton and BMP-2, TGF-beta, SOX-9 production in rat temporomandibular synovial fibroblasts.
Regulation (Effects) of BMP-2 in fibroblasts
3) Confidence 0.43 Published 2008 Journal Osteoarthr. Cartil. Section Title Doc Link 17631391 Disease Relevance 0.46 Pain Relevance 0.21
The purpose of this study was to investigate the effect of acid conditioning of root surfaces during recombinant human bone morphogenetic protein-2 (rhBMP-2) induced periodontal regeneration in vivo.
Spec (investigate) Regulation (effect) of bone morphogenetic protein-2
4) Confidence 0.38 Published 1998 Journal J. Periodontol. Section Abstract Doc Link 9623899 Disease Relevance 0 Pain Relevance 0.08
This study was instituted to observe the effect of rhBMP-2 in a collagen carrier without concomitant bone grafting material in the restoration of continuity critical-sized defects of the mandible.
Regulation (effect) of rhBMP-2 in mandible
5) Confidence 0.34 Published 2008 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 18355584 Disease Relevance 0.09 Pain Relevance 0.09
This study examines the effects of hydrostatic pressure (HP) on cytoskeleton and protein production of bone morphogenetic protein-2 (BMP-2), transforming growth factor-beta (TGF-beta) and the SRY HMG box related gene 9 (SOX-9) in synovial fibroblasts (SFs) of rat temporomandibular joint (TMJ).
Spec (examines) Regulation (effects) of BMP-2 in SFs associated with snapping jaw
6) Confidence 0.32 Published 2008 Journal Osteoarthr. Cartil. Section Abstract Doc Link 17631391 Disease Relevance 0.58 Pain Relevance 0.24
This study examines the effects of hydrostatic pressure (HP) on cytoskeleton and protein production of bone morphogenetic protein-2 (BMP-2), transforming growth factor-beta (TGF-beta) and the SRY HMG box related gene 9 (SOX-9) in synovial fibroblasts (SFs) of rat temporomandibular joint (TMJ).
Spec (examines) Regulation (effects) of bone morphogenetic protein-2 in SFs associated with snapping jaw
7) Confidence 0.32 Published 2008 Journal Osteoarthr. Cartil. Section Abstract Doc Link 17631391 Disease Relevance 0.58 Pain Relevance 0.24
The induction of astrocyte activation is also reflected by an up-regulation of BMP-2, STAT3 and p300 which are factors in the BMP signalling pathway.
Regulation (regulation) of BMP-2 in astrocyte
8) Confidence 0.25 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.29 Pain Relevance 0.24
In the present study, we evaluated the effect of the direct and simultaneous gene transfer of human BMP-2 and BMP-7 gene expression vectors (pCAGGS-BMP-2 and pCAGGS-BMP-7) on osteoinduction using in vivo electroporation.
Regulation (effect) of BMP-2
9) Confidence 0.23 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0.05 Pain Relevance 0
For example, a single vector that can express BMP-2 and BMP-7 simultaneously might be useful for assessing the influence of the BMP-2/7 heterodimer on osteoinductive activity in vivo.
Regulation (influence) of BMP-2
10) Confidence 0.23 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1557501 Disease Relevance 0 Pain Relevance 0
Von Knoch et al. showed that a cascade of osteoblast-related genes including BMP-2, cbfa-1, type 1 collagen and Bone Sialo-Proteins (BSP) were up regulated and significantly increased in bone marrow stromal cells after BP treatment [11].
Regulation (regulated) of BMP-2 in stromal cells associated with osteoporosis
11) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945066 Disease Relevance 0.52 Pain Relevance 0.03

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