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Context Info
Confidence 0.77
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 28
Disease Relevance 13.33
Pain Relevance 4.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adm) aging (Adm) extracellular region (Adm)
response to stress (Adm) cytoplasm (Adm)
Anatomy Link Frequency
plasma 2
endometrium 2
nerves 2
canal 1
joints 1
Adm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 122 100.00 Very High Very High Very High
Calcitonin gene-related peptide 75 100.00 Very High Very High Very High
adenocard 19 100.00 Very High Very High Very High
Dismenorea 10 99.68 Very High Very High Very High
metalloproteinase 185 99.56 Very High Very High Very High
corticosteroid 20 99.44 Very High Very High Very High
headache 8 98.28 Very High Very High Very High
Angina 2 98.24 Very High Very High Very High
cerebral cortex 8 97.96 Very High Very High Very High
orphanin 8 94.68 High High
Disease Link Frequency Relevance Heat
Pancreatitis 171 100.00 Very High Very High Very High
Cancer 113 100.00 Very High Very High Very High
Necrosis 25 100.00 Very High Very High Very High
Sepsis 7 99.84 Very High Very High Very High
Reprotox - General 1 14 99.68 Very High Very High Very High
Pulmonary Hypertension 301 99.56 Very High Very High Very High
Apoptosis 66 99.44 Very High Very High Very High
Dysmenorrhea 2 99.08 Very High Very High Very High
Vomiting 7 98.72 Very High Very High Very High
Nociception 1 98.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma adrenomedullin levels in the coronary circulation in vasospastic angina pectoris.
Gene_expression (levels) of adrenomedullin in Plasma associated with angina
1) Confidence 0.77 Published 2000 Journal Am. J. Cardiol. Section Title Doc Link 11078285 Disease Relevance 0.19 Pain Relevance 0.19
Because ADM is overexpressed in sepsis, we repeated the above protocol in cells isolated from LPS-treated rats.
Gene_expression (overexpressed) of ADM associated with sepsis
2) Confidence 0.68 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14766677 Disease Relevance 0.27 Pain Relevance 0.13
Regulation of MMP-12 activity and gene expression by MAPKs, PI3-K and corticosteroid
Gene_expression (expression) of AP associated with corticosteroid and metalloproteinase
3) Confidence 0.65 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.62
MAP kinase pathways have also been shown to be involved in ATII signaling in PSCs [37,38].
Gene_expression (pathways) of AP
4) Confidence 0.65 Published 2004 Journal Mol Cancer Section Body Doc Link PMC524499 Disease Relevance 0.57 Pain Relevance 0.08
Adrenomedullin expression is up-regulated by acute hypobaric hypoxia in the cerebral cortex of the adult rat.
Gene_expression (expression) of Adrenomedullin in cerebral cortex associated with hypoxia and cerebral cortex
5) Confidence 0.64 Published 2008 Journal Brain Pathol. Section Title Doc Link 18371176 Disease Relevance 0.65 Pain Relevance 0.22
Most authors call such additional ADM head an "accessory" component which can be unilaterally or bilaterally presented, producing compression in Guyon's canal.
Gene_expression (head) of ADM in canal
6) Confidence 0.55 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245941 Disease Relevance 0 Pain Relevance 0
Harvie et al., found an accessory ADM in 41% of 116 volunteers' asymptomatic ultrasound examinations, greater prevalence being found in male samples and bilateral presentation in 50% of cases for both genders.
Gene_expression (presentation) of ADM
7) Confidence 0.55 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2245941 Disease Relevance 0 Pain Relevance 0
We also demonstrated that a CGRP superfamily peptide, adrenomedullin, is distributed in perivascular nerves of rat mesenteric resistance arteries.
Gene_expression (distributed) of adrenomedullin in nerves associated with calcitonin gene-related peptide
8) Confidence 0.55 Published 2007 Journal Neuroscience Section Abstract Doc Link 17101235 Disease Relevance 0 Pain Relevance 0.36
ADM infusion elevated (P<.05) plasma ADM levels in ADM-infused SHR (679+/-47 pg/mL in ADM-50, 858+/-79 in ADM-100) compared with control (79.5+/-27.8).
Gene_expression (levels) of ADM in plasma
9) Confidence 0.52 Published 1997 Journal Hypertension Section Abstract Doc Link 9323000 Disease Relevance 0.60 Pain Relevance 0
mg/kg/day), or (3) a peptide consisting of the Cav-1–scaffolding domain coupled to AP (AP-Cav; 2.5?
Gene_expression (2.5) of AP
10) Confidence 0.50 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 1.02 Pain Relevance 0
MCT and MCT+AP rats developed PAH.
Gene_expression (rats) of AP associated with pulmonary hypertension
11) Confidence 0.44 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 1.08 Pain Relevance 0
Here we report the changes in adrenomedullin (AM) expression observed in rats exposed to hypobaric hypoxia and different times of reoxygenation.
Gene_expression (expression) of adrenomedullin associated with hypoxia
12) Confidence 0.43 Published 2008 Journal Brain Pathol. Section Abstract Doc Link 18371176 Disease Relevance 0.66 Pain Relevance 0.22
PTN posterior tibial nerve, ICN inferior calcaneal nerve, LPN lateral plantar nerve, MPN medial plantar nerveFig. 4An anatomic drawing of a coronal section through the right talocrural and talocalcaneal joints (ADM abductor digiti minimi muscle, FDB flexor digitorum brevis muscle, AH abductor hallucis muscle)
Gene_expression (muscle) of ADM in joints
13) Confidence 0.18 Published 2008 Journal Skeletal Radiol Section Body Doc Link PMC2335296 Disease Relevance 1.01 Pain Relevance 0.12
Thus, the CR/RAMP-1 and CR/RAMP-3 heterodimer form amylin receptors, the CLR/RAMP-1 heterodimer functions as the CGRP receptor, and both CLR/RAMP-2 and CLR/RAMP-3 are functional adrenomedullin receptors.
Gene_expression (receptors) of adrenomedullin associated with calcitonin gene-related peptide
14) Confidence 0.14 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.05
Intermedin/adrenomedullin-2, the PRL-releasing factor (PRF) from the neurointermediate lobe (NIL)?
Gene_expression (/) of adrenomedullin in NIL
15) Confidence 0.14 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.06 Pain Relevance 0.03
It is also most important to realise that calcitonin, adrenomedullin and CGRP are made by gonadotrophs (see above) and IMD is made by corticotrophs and melanotrophs.
Gene_expression (made) of adrenomedullin in melanotrophs associated with calcitonin gene-related peptide
16) Confidence 0.12 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.14
Malon dialdehyde, nitrite and adrenomedullin levels in patients with premenstrual syndrome.
Gene_expression (levels) of adrenomedullin associated with dismenorea
17) Confidence 0.12 Published 2007 Journal Arch. Gynecol. Obstet. Section Title Doc Link 17063355 Disease Relevance 0.10 Pain Relevance 0.19
Finally, treatment with phenelzine resulted in up-regulation of three (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Fyn proto-oncogene), 14 (Nerve growth factor beta, Midkine, Type 1 tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Leptin receptor, Adrenomedullin, Arrestin beta 1, Syntaxin 1A, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein), and five (Transforming growth factor beta 2, Growth differentiation factor 15, Regucalcin, Syntaxin 11, Homogentisate 1, 2-dioxygenase) genes and down-regulation of four (Immunoglobulin superfamily member 6, Secreted phosphoprotein 1, Phospholipase A2 activating protein, Tumor necrosis factor receptor superfamily member 6), three (Serum amyloid A 4, Apoptosis facilitator Bcl-2-like protein 14, Interferon gamma), and two (Tumor necrosis factor alpha induced protein 6, Granzyme A) genes after treatment for one, three and seven days, respectively (Table 1 and 2).
Gene_expression (expressed) of Adrenomedullin in Nerve associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia and apoptosis
18) Confidence 0.12 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.62 Pain Relevance 0.25
Malondialdehyde, nitric oxide and adrenomedullin levels in patients with primary dysmenorrhea.
Gene_expression (levels) of adrenomedullin associated with dismenorea
19) Confidence 0.10 Published 2008 Journal J. Obstet. Gynaecol. Res. Section Title Doc Link 19012707 Disease Relevance 0.19 Pain Relevance 0.29
AIM: The aim of the study was to examine whether there was a relationship between primary dysmenorrhea and serum levels of malondialdehyde (MDA), nitric oxide (NO) and adrenomedullin (AM) in young women.
Gene_expression (levels) of adrenomedullin associated with dismenorea
20) Confidence 0.09 Published 2008 Journal J. Obstet. Gynaecol. Res. Section Abstract Doc Link 19012707 Disease Relevance 0.17 Pain Relevance 0.17

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