INT70877

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Context Info
Confidence 0.75
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 72
Total Number 74
Disease Relevance 22.39
Pain Relevance 10.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PPIG) protein folding (PPIG) nucleoplasm (PPIG)
nucleolus (PPIG) nucleus (PPIG) cytoplasm (PPIG)
Anatomy Link Frequency
liver 10
CPA 3
hepatocytes 2
pancreas 2
1A2 2
PPIG (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 116 100.00 Very High Very High Very High
agonist 88 100.00 Very High Very High Very High
Buprenorphine 23 99.90 Very High Very High Very High
Pain 21 99.90 Very High Very High Very High
Paracetamol 52 99.42 Very High Very High Very High
methadone 9 99.22 Very High Very High Very High
rapifen 14 99.06 Very High Very High Very High
tramadol 20 98.88 Very High Very High Very High
Analgesic 19 98.88 Very High Very High Very High
Oxycodone 7 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 22 99.90 Very High Very High Very High
Cancer 1765 99.84 Very High Very High Very High
Injury 97 99.84 Very High Very High Very High
Metastasis 41 99.84 Very High Very High Very High
Hypoxia 60 99.66 Very High Very High Very High
Toxicity 571 98.64 Very High Very High Very High
Hepatotoxicity 48 98.36 Very High Very High Very High
Brain Tumor 13 98.24 Very High Very High Very High
Vasculitis 61 97.88 Very High Very High Very High
Apoptosis 47 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, meclizine suppresses hCAR transactivation and inhibits the phenobarbital-induced expression of the CAR target genes, cytochrome p450 monooxygenase (CYP)2B10, CYP3A11, and CYP1A2, in primary hepatocytes derived from mice expressing hCAR, but not mCAR.
Gene_expression (expression) of CYP in hepatocytes
1) Confidence 0.75 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 15272053 Disease Relevance 0.17 Pain Relevance 0.29
DMO production by human cDNA expressed CYP enzymes was observed mainly for CYP2E1 (10.8 nmol/tube), marginally for CYP2C8 (0.22 nmol/tube) and not detectable for other CYP enzymes. 4.
Gene_expression (expressed) of CYP in tube
2) Confidence 0.75 Published 1998 Journal Xenobiotica Section Abstract Doc Link 9879636 Disease Relevance 0 Pain Relevance 0.07
OBJECTIVE: The aim of this study was to assess the drug interaction potential of psychotropic medication on methadone N-demethylation using cDNA-expressed cytochrome P450 CYP enzymes.
Gene_expression (expressed) of CYP associated with methadone
3) Confidence 0.75 Published 2007 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 17598095 Disease Relevance 0 Pain Relevance 0.17
Various cells with higher expression of cytochrome P-450 (CYP) would metabolize AP and lead to cellular impairment.
Gene_expression (expression) of CYP associated with paracetamol
4) Confidence 0.73 Published 2002 Journal J. Med. Dent. Sci. Section Abstract Doc Link 12641380 Disease Relevance 0.23 Pain Relevance 0.68
INTERVENTIONS: The expression of microsomal cytochrome P450 (CYP) isoenzymes was examined after daily treatment of rats with intravenous zanamivir.
Gene_expression (expression) of CYP
5) Confidence 0.67 Published 1999 Journal Clin Pharmacokinet Section Body Doc Link 10429839 Disease Relevance 0 Pain Relevance 0
Since individual CYP forms differ markedly in their substrate preferences and regulation, the expression profiles of CYP in various cell types are important determinants in tissue-specific toxicity.
Gene_expression (expression) of CYP associated with toxicity
6) Confidence 0.67 Published 1997 Journal Environ Health Perspect Section Abstract Doc Link PMC1470056 Disease Relevance 0.33 Pain Relevance 0.07
Oxycodone, frequently prescribed for the relief of moderate to severe pain, is metabolized by cytochrome P450 (CYP) 2D6, encoded by a polymorphic gene with three mutations (*3, *4, and *5) with a combined 95% allelic frequency and about 10% prevalence.
Gene_expression (metabolized) of CYP associated with pain and oxycodone
7) Confidence 0.65 Published 2002 Journal J Anal Toxicol Section Abstract Doc Link 12422998 Disease Relevance 0.18 Pain Relevance 0.59
The rats with protein-calorie malnutrition (PCM, 5% casein diet for a period of 4-week) were reported to exhibit 60 and 80% suppression in the hepatic microsomal cytochrome P450 (CYP) 1A2 and CYP2C11 levels, respectively, and 40-50% decreases in CYP2E1 and CYP3A1/2 levels compared to control (23% casein diet for a period of 4-week) based on Western blot analysis.
Gene_expression (levels) of CYP in 1A2 associated with appetite loss
8) Confidence 0.65 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15356995 Disease Relevance 0.17 Pain Relevance 0
Hydroxy-BUP was produced by the CYP 3A, but not the 2C isoforms.
Gene_expression (produced) of CYP associated with buprenorphine
9) Confidence 0.65 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15743975 Disease Relevance 0 Pain Relevance 1.06
The genetic damage in exposed individuals was measured by means of the comet test, chromosomal alterations test, and the study of the CYP 1A1 and MSH2 genes.
Gene_expression (study) of CYP
10) Confidence 0.65 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18991910 Disease Relevance 0.55 Pain Relevance 0.09
Cytochrome P450 (CYP) 2D6 is one of the most investigated CYPs in relation to genetic polymorphism, but accounts for only a small percentage of all hepatic CYPs (approximately 2-4%).
Gene_expression (one) of CYP
11) Confidence 0.65 Published 2009 Journal Clin Pharmacokinet Section Abstract Doc Link 19817501 Disease Relevance 0.06 Pain Relevance 0.19
RESULTS: Zanamivir had no effect on the expression of microsomal CYP isoenzymes after daily intravenous treatment of rats with zanamivir 1, 9 or 90 mg/kg for 5 weeks.
Gene_expression (expression) of CYP
12) Confidence 0.58 Published 1999 Journal Clin Pharmacokinet Section Body Doc Link 10429839 Disease Relevance 0 Pain Relevance 0
The oxidative metabolism of xenobiotics is effected mainly by cytochrome P450 enzymes (CYP), which are expressed as a family of genetically related enzymes primarily in hepatocytes.
Gene_expression (expressed) of CYP in hepatocytes
13) Confidence 0.57 Published 1998 Journal Pancreas Section Abstract Doc Link 9598815 Disease Relevance 0.23 Pain Relevance 0.15
However, due to species differences in CYP expression, activity and induction, it is not possible extrapolate the results of these animal studies to clinical situations in humans.
Gene_expression (expression) of CYP
14) Confidence 0.57 Published 2002 Journal Drug Saf Section Abstract Doc Link 12137557 Disease Relevance 0.61 Pain Relevance 0.97
Twenty-four normal pancreases from 7 donors and 17 early autopsy cases, as well as cultured human islet cells, were analyzed by immunohistochemistry, Western blot analysis, and/or reverse-transcription polymerase chain reaction (RT-PCR) for the expression of nine cytochrome P-450 mono-oxygenases (CYP) and the NADPH cytochrome P-450 oxidoreductase.
Gene_expression (expression) of CYP
15) Confidence 0.55 Published 2002 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 12396872 Disease Relevance 0.24 Pain Relevance 0.08
CYP 2B6 was expressed in all 7 donor pancreas, compared to 8 of 17 autopsy cases.
Gene_expression (expressed) of CYP in pancreas
16) Confidence 0.55 Published 2002 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 12396872 Disease Relevance 0.21 Pain Relevance 0.06
The pancreas is among the extrahepatic tissues expressing CYP, and it has been suggested that intermediates generated by them might be of pathogenetic significance for diseases of the pancreas such as chronic pancreatitis.
Gene_expression (expressing) of CYP in pancreas associated with disease and chronic pancreatitis
17) Confidence 0.50 Published 1998 Journal Pancreas Section Abstract Doc Link 9598815 Disease Relevance 0.27 Pain Relevance 0.17
Finally, CYP1A2 and CYP2E1 cDNA-expressed forms of human CYP did not allow PPX formation, CYP2C19 and CYP2D6 produced only small amounts whereas CYP3A4 most efficiently metabolized bupivacaine into PPX.
Gene_expression (expressed) of CYP
18) Confidence 0.49 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10725304 Disease Relevance 0 Pain Relevance 0.05
These results show the metabolic activation of APAP, CPA and BA by the specific CYP subtypes expressed in the transformants and demonstrate the usefulness of these transformants for in vitro metabolic and toxicological studies in human liver.
Gene_expression (expressed) of CYP in CPA associated with paracetamol
19) Confidence 0.49 Published 2001 Journal Toxicol In Vitro Section Abstract Doc Link 11377097 Disease Relevance 0 Pain Relevance 0.28
The apparent K(m) values of the expressed CYP subtypes for their specific substrates were close to those of human liver microsomes.
Gene_expression (expressed) of CYP in liver
20) Confidence 0.49 Published 2001 Journal Toxicol In Vitro Section Abstract Doc Link 11377097 Disease Relevance 0 Pain Relevance 0.20

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