INT70958

From wiki-pain
Revision as of 17:57, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 11.84
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOS3) aging (NOS3) Golgi apparatus (NOS3)
mitochondrion organization (NOS3) cytoplasm (NOS3) cytosol (NOS3)
Anatomy Link Frequency
hepatocytes 1
chest 1
platelets 1
NOS3 (Homo sapiens)
NOS3 - E298D (3)
Pain Link Frequency Relevance Heat
cannabis 2 100.00 Very High Very High Very High
b2 receptor 2 100.00 Very High Very High Very High
Migraine 8 99.98 Very High Very High Very High
aspirin 24 99.42 Very High Very High Very High
cINOD 65 98.28 Very High Very High Very High
COX-2 inhibitor 6 97.82 Very High Very High Very High
COX2 4 96.88 Very High Very High Very High
Glutamate 9 95.72 Very High Very High Very High
Angina 17 95.68 Very High Very High Very High
bradykinin 4 95.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nicotine Addiction 64 100.00 Very High Very High Very High
Headache 11 99.98 Very High Very High Very High
Stress 131 99.96 Very High Very High Very High
Disease 69 99.36 Very High Very High Very High
Coronary Artery Disease 141 99.12 Very High Very High Very High
Myocardial Infarction 154 99.04 Very High Very High Very High
Insulin Resistance 3 98.36 Very High Very High Very High
Coronary Heart Disease 30 97.84 Very High Very High Very High
Acute Chest Syndrome 3 97.68 Very High Very High Very High
Increased Venous Pressure Under Development 66 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to determine the mechanism by which aspirin acutely increases the activity of NO synthase type 3 (NOS-3), the predominant NOS isoform expressed by platelets, and specifically whether this occurs through an increase in its acetylation.
NOS-3 Binding (activity) of in platelets associated with aspirin
1) Confidence 0.37 Published 2009 Journal Cardiovasc. Res. Section Abstract Doc Link 19377066 Disease Relevance 0.10 Pain Relevance 0.23
In addition, other recent studies failed to find any association between the Asp298 variant and eNOS activity [22,23].
eNOS Binding (association) of
2) Confidence 0.37 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1239913 Disease Relevance 0.27 Pain Relevance 0
Migraine association and linkage studies of an endothelial nitric oxide synthase (NOS3) gene polymorphism.
NOS3 Binding (association) of associated with migraine
3) Confidence 0.36 Published 1997 Journal Neurology Section Title Doc Link 9270610 Disease Relevance 0.73 Pain Relevance 0.69
A common variant of endothelial nitric oxide synthase (Glu298Asp) is associated with collateral development in patients with chronic coronary occlusions

Background

endothelial nitric oxide synthase (E298D) Binding (associated) of associated with coronary heart disease
4) Confidence 0.36 Published 2005 Journal BMC Cardiovasc Disord Section Title Doc Link PMC1239913 Disease Relevance 0.25 Pain Relevance 0.04
In vitro studies have suggested that the Asp298 variant may be functional and associated with a decreased of eNOS activity [10].
eNOS Binding (associated) of
5) Confidence 0.32 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1239913 Disease Relevance 0.43 Pain Relevance 0.09
The association between eNOS E298D polymorphism and MI is strongly affected by cigarette smoking.
eNOS (E298D) Binding (association) of associated with nicotine addiction and myocardial infarction
6) Confidence 0.32 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2954842 Disease Relevance 1.75 Pain Relevance 0
Association of the eNOS E298D polymorphism and the risk of myocardial infarction in the Greek population

Background

eNOS (E298D) Binding (Association) of associated with myocardial infarction
7) Confidence 0.31 Published 2010 Journal BMC Med Genet Section Title Doc Link PMC2954842 Disease Relevance 0.55 Pain Relevance 0
The functional association between vascular nNOS and eNOS with respect to the regulation of tone and how this may be altered in disease settings also requires further study.
eNOS Binding (association) of associated with disease
8) Confidence 0.25 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.37 Pain Relevance 0.05
Little is known about the association of endothelial nitric oxide synthase (NOS3) gene polymorphisms and the presence of insulin resistance and the early evolution of atherosclerosis in nondiabetic subjects with cardiovascular disease (CAD) and stent implantation.
NOS3 Binding (association) of associated with coronary artery disease, cardiovascular disease, increased venous pressure under development and insulin resistance
9) Confidence 0.21 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18349107 Disease Relevance 0.73 Pain Relevance 0.03
For example, a recent study showed that both COX-2 inhibitors and traditional NSAIDs upregulate vascular NADPH (nicotinamide adenine dinucleotide phosphate) oxidases and uncouple eNOS, leading to endothelial dysfunction [36].
eNOS Binding (uncouple) of associated with cinod and cox-2 inhibitor
10) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582806 Disease Relevance 0.70 Pain Relevance 0.84
Stromelysin-1 5A/6A and eNOS T-786C polymorphisms, MTHFR C677T and A1298C mutations, and cigarette-cannabis smoking: a pilot, hypothesis-generating study of gene-environment pathophysiological associations with Buerger's disease.
eNOS Binding (associations) of associated with cannabis, nicotine addiction and disease
11) Confidence 0.15 Published 2006 Journal Clin. Appl. Thromb. Hemost. Section Title Doc Link 17000887 Disease Relevance 1.41 Pain Relevance 0.14
Moreover, direct physical interaction between the bradykinin B2 receptor and eNOS yields a reversible inhibitory complex that is readily dissociated on ligand binding and/or elevations in [Ca2+]i, thereby providing another counter-regulatory mechanism between GPCR/Ca2+- and NOS/cGMP-regulated signalling systems [81].
eNOS Binding (interaction) of associated with b2 receptor
12) Confidence 0.15 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.17
While we have not been able to find any evidence for a direct interaction between eNOS and TP?
eNOS Binding (interaction) of
13) Confidence 0.13 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.12
For example, the antioxidant superoxide dismutase (SOD) combats oxidative stress, endothelial nitric oxide synthetase (eNOS) inhibits the activation of NF-?
eNOS Binding (endothelial) of associated with stress
14) Confidence 0.10 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 0.84 Pain Relevance 0.26
In situ RT-PCR was also carried out to co-localize the eNOS messengers and the VSMC phenotype.
eNOS Binding (co-localize) of
15) Confidence 0.09 Published 2005 Journal Eur J Histochem Section Abstract Doc Link 15823793 Disease Relevance 1.09 Pain Relevance 0.36
Three types of NOS have been identified: endothelial NO synthase (eNOS), which is bound to plasma membranes and known to be strongly activated by the entry of calcium through membrane-bound receptors [59]; inducible NO synthase (iNOS), which was first identified in macrophages and then in other cells, including hepatocytes, is known to be up-regulated by pro-inflammatory cytokines and/or lipopolysaccharide (LPS), and is able to generate low levels of NO compared with the other NOS isoforms; and neuronal NO synthase (nNOS) (Figure 4).
eNOS Binding (bound) of in hepatocytes associated with inflammation and cytokine
16) Confidence 0.08 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.29 Pain Relevance 0.09
This retrospective study reveals that ET-1 T8002 and ecNOS C-786 alleles are associated with, respectively, an increased and a decreased risk of acute chest syndrome.
ecNOS Binding (associated) of in chest associated with acute chest syndrome
17) Confidence 0.08 Published 2006 Journal Haematologica Section Abstract Doc Link 16956834 Disease Relevance 0.34 Pain Relevance 0.17
Although the distribution of genotypes in both the CAD and the control groups satisfied the Hardy-Weinberg equilibrium, the G894T polymorphism of the NOS3 gene was significantly associated with the presence of CAD in our patients (?
NOS3 Binding (associated) of associated with coronary artery disease
18) Confidence 0.04 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2850180 Disease Relevance 0.89 Pain Relevance 0
In an Australian population, Cai et al did not detect any association between NOS3 gene polymorphism and the risk of CAD.19 Hibi et al showed that patients who are homozygous for the Glu298Asp polymorphism might be genetically predisposed to acute MI; however, this mutation apparently is not related to the severity of coronary atherosclerosis.15 In contrast, Hingorani et al observed an excess of homozygotes for Asp298 variant among patients with CAD.
NOS3 Binding (association) of associated with coronary artery disease and myocardial infarction
19) Confidence 0.04 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2850180 Disease Relevance 1.12 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox