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Context Info
Confidence 0.77
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 54
Total Number 54
Disease Relevance 63.68
Pain Relevance 8.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
leg 4
Heart 3
plasma 2
muscle 2
blood 2
pad (Mus musculus)
Pain Link Frequency Relevance Heat
cva 72 100.00 Very High Very High Very High
depression 11 100.00 Very High Very High Very High
Paracetamol 11 100.00 Very High Very High Very High
Restless leg syndrome 418 99.84 Very High Very High Very High
imagery 3 99.84 Very High Very High Very High
Pain 226 99.32 Very High Very High Very High
medulla 5 98.72 Very High Very High Very High
ischemia 172 96.40 Very High Very High Very High
antagonist 3 87.04 High High
addiction 10 84.00 Quite High
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 2017 100.00 Very High Very High Very High
Coronary Artery Disease 399 100.00 Very High Very High Very High
Diabetes Mellitus 320 100.00 Very High Very High Very High
Cv General 3 Under Development 77 100.00 Very High Very High Very High
Depression 11 100.00 Very High Very High Very High
Atherosclerosis 195 99.84 Very High Very High Very High
Hypothyroidism 50 99.84 Very High Very High Very High
Increased Venous Pressure Under Development 645 99.80 Very High Very High Very High
Congenital Anomalies 3 99.64 Very High Very High Very High
Pain 205 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most classic symptomatic expression of PAD is intermittent claudication.
Gene_expression (expression) of PAD associated with restless leg syndrome and peripheral arterial disease
1) Confidence 0.77 Published 2005 Journal J. Thromb. Haemost. Section Abstract Doc Link 16102028 Disease Relevance 1.15 Pain Relevance 0.27
PAD was also highly prevalent among the younger patients.
Gene_expression (prevalent) of PAD associated with peripheral arterial disease
2) Confidence 0.67 Published 2003 Journal Int. J. Clin. Pract. Section Abstract Doc Link 12846339 Disease Relevance 1.72 Pain Relevance 0.09
Both calf and non-calf IC had similar overall accuracy for detecting PAD.
Gene_expression (detecting) of PAD
3) Confidence 0.66 Published 2009 Journal Eur. J. Intern. Med. Section Body Doc Link 19524189 Disease Relevance 0.29 Pain Relevance 0
The early detection of PAD with ABI screening and subsequent medical management represents a critical opportunity to prevent considerable vascular morbidity and mortality.
Gene_expression (detection) of PAD associated with peripheral arterial disease
4) Confidence 0.66 Published 2010 Journal Ann. Med. Section Abstract Doc Link 20156042 Disease Relevance 1.67 Pain Relevance 0.08
The fractions were assayed for their ability to bioactivate APAP to N-acetyl-p-benzoquinone imine, which was trapped as APAP-glutathione conjugates or APAP-protein adducts, and for dimethyl-nitrosamine-N-demethylase (DMN), 4-nitrophenol hydroxylase (4-NPOH), and phenacetin-O-deethylase (PAD) activities.
Gene_expression (assayed) of PAD associated with paracetamol and peripheral arterial disease
5) Confidence 0.62 Published 1993 Journal Life Sci. Section Abstract Doc Link 8355558 Disease Relevance 0.26 Pain Relevance 0.94
Non-invasive ultrasound and colour duplex techniques have revolutionised the detection of PAD, and the long-term surveillance of disease progression, while antiplatelet therapy coupled with risk factor modification (lipids, blood pressure and glycaemic control and smoking cessation) are aimed at reducing direct or indirect vascular complications, e.g. amputation or CHD death.
Gene_expression (detection) of PAD in blood associated with coronary artery disease, nicotine addiction, amputation, peripheral arterial disease, death and disease progression
6) Confidence 0.60 Published 2001 Journal Int J Clin Pract Suppl Section Abstract Doc Link 11355275 Disease Relevance 1.30 Pain Relevance 0.15
The presence of PAD is a high risk marker of cardiac events and stroke.
Gene_expression (presence) of PAD associated with stroke and peripheral arterial disease
7) Confidence 0.60 Published 2002 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 12138819 Disease Relevance 0.67 Pain Relevance 0.10
The ankle brachial index is an excellent screening test for the presence of PAD.
Gene_expression (presence) of PAD in ankle associated with peripheral arterial disease
8) Confidence 0.58 Published 2010 Journal Mayo Clin. Proc. Section Abstract Doc Link 20592174 Disease Relevance 1.54 Pain Relevance 0.17
The clinical presentation of PAD is quite varied, including patients with atypical leg symptoms, classic intermittent claudication, and critical limb ischemia.
Gene_expression (presentation) of PAD in leg associated with ischemia, restless leg syndrome and peripheral arterial disease
9) Confidence 0.58 Published 2010 Journal Tech Vasc Interv Radiol Section Abstract Doc Link 20123428 Disease Relevance 1.43 Pain Relevance 0.14
In conclusion, it appears that LIPFE training is an effective intervention for individuals presenting with PAD.
Gene_expression (presenting) of PAD associated with peripheral arterial disease
10) Confidence 0.58 Published 2009 Journal Angiology Section Abstract Doc Link 18818240 Disease Relevance 0.79 Pain Relevance 0.31
With improved understanding of the disease process, risk factors and treatment, clinicians will be able to detect PAD earlier, provide diagnosis, treat and manage this disease.
Gene_expression (detect) of PAD associated with peripheral arterial disease and disease
11) Confidence 0.55 Published 2009 Journal J Vasc Nurs Section Abstract Doc Link 19486852 Disease Relevance 1.89 Pain Relevance 0.03
PAD was detected in 63/345 (18.2%) osteoporotic women and in 14/360 (3.8%) control subjects (P < 0.0001).
Gene_expression (detected) of PAD associated with peripheral arterial disease
12) Confidence 0.53 Published 2006 Journal J. Bone Miner. Metab. Section Abstract Doc Link 16502119 Disease Relevance 0.84 Pain Relevance 0.06
Therefore, the treatment and prevention of progression of PAD is critically important.
Gene_expression (progression) of PAD associated with peripheral arterial disease
13) Confidence 0.52 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2293969 Disease Relevance 1.79 Pain Relevance 0.24
A simple bedside measure of the AAI can be used to improve the detection of PAD in clinical practice.
Gene_expression (detection) of PAD associated with peripheral arterial disease
14) Confidence 0.52 Published 2000 Journal J Am Geriatr Soc Section Abstract Doc Link 10983919 Disease Relevance 2.08 Pain Relevance 0.15
The systematic implementation of Edinburgh Claudication Questionnaire could be a valuable call-to-action to improve clinical evaluation of PAD, bearing in mind that PAD detected by either non-calf or classic IC must be confirmed by ABI testing.


Gene_expression (detected) of PAD
15) Confidence 0.51 Published 2009 Journal Eur. J. Intern. Med. Section Body Doc Link 19524189 Disease Relevance 0.23 Pain Relevance 0
The presence of PAD and IC was determined by measuring the ankle-arm systolic blood pressure index (AAI) and by means of the World Health Organization/Rose questionnaire, respectively.
Gene_expression (presence) of PAD in blood associated with restless leg syndrome and peripheral arterial disease
16) Confidence 0.51 Published 1998 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9484982 Disease Relevance 1.06 Pain Relevance 0.47
The presence of PAD and IC was determined by an ankle-brachial index (ABI) <0.90 in either leg and by means of the Edinburgh questionnaire, respectively, fulfilled together with a detailed past history.
Gene_expression (presence) of PAD in leg
17) Confidence 0.51 Published 2009 Journal Int Angiol Section Body Doc Link 19190551 Disease Relevance 0.18 Pain Relevance 0
In the second part, significant PAD was found in 111 cases corresponding to a prevalence of 12.2%.
Gene_expression (found) of PAD associated with peripheral arterial disease
18) Confidence 0.51 Published 2008 Journal Clin Physiol Funct Imaging Section Abstract Doc Link 18803641 Disease Relevance 1.10 Pain Relevance 0.08
The purpose of the present series of experiments was to analyze, in anesthetized and paralyzed cats, the effects of (-)-baclofen and picrotoxin on the primary afferent depolarization (PAD) generated in single Ib afferent fibers by either intraspinal microstimulation or stimulation of the segmental and descending pathways.
Gene_expression (generated) of PAD associated with peripheral arterial disease and paralysis
19) Confidence 0.51 Published 1992 Journal Exp Brain Res Section Abstract Doc Link 1338717 Disease Relevance 0.48 Pain Relevance 0.05
Twenty to forty minutes after the i.v. injection of picrotoxin (0.5-1 mg/kg), there was a strong depression of the PAD elicited by stimulation of muscle and cutaneous afferents as well as of the PAD produced by stimulation of the RF and the PAD produced by intraspinal microstimulation.
Gene_expression (produced) of PAD in muscle associated with depression and peripheral arterial disease
20) Confidence 0.51 Published 1992 Journal Exp Brain Res Section Abstract Doc Link 1338717 Disease Relevance 0.95 Pain Relevance 0.17

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