INT7113

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Context Info
Confidence 0.51
First Reported 1980
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 71
Total Number 81
Disease Relevance 17.70
Pain Relevance 23.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CGA) small molecule metabolic process (CGA) extracellular region (CGA)
cellular nitrogen compound metabolic process (CGA) cell-cell signaling (CGA)
Anatomy Link Frequency
pituitary 22
gonadal 8
Leydig cells 4
hypothalamus 4
neurons 4
CGA (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 145 100.00 Very High Very High Very High
antagonist 91 100.00 Very High Very High Very High
Opioid 83 100.00 Very High Very High Very High
agonist 66 100.00 Very High Very High Very High
Endogenous opioid 38 99.98 Very High Very High Very High
Neuropeptide 35 99.98 Very High Very High Very High
aspirin 6 99.98 Very High Very High Very High
Morphine 26 99.92 Very High Very High Very High
gABA 5 99.68 Very High Very High Very High
Catecholamine 6 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 41 99.98 Very High Very High Very High
Hypoglycemia 2 99.98 Very High Very High Very High
Stress 51 99.84 Very High Very High Very High
Obesity 48 99.66 Very High Very High Very High
Opiate Addiction 5 99.50 Very High Very High Very High
Diabetes Mellitus 107 99.48 Very High Very High Very High
Breast Cancer 18 99.42 Very High Very High Very High
Reprotox - General 1 99 99.40 Very High Very High Very High
Reprotox - General 2 85 99.36 Very High Very High Very High
Appetite Loss 12 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A study was performed on eight subjects with Klinefelter's syndrome to assess the relation between gonadal hormones and opioid inhibition of gonadotropin secretion through comparison of their gonadotropin response to naloxone (NAL) (0.3 mg/kg; 1/3 bolus iv. at time 0 and 2/3 iv. for 120 min) before and after testosterone propionate (TP) 100 mg/day im. for 5 days.
Negative_regulation (inhibition) of Localization (secretion) of gonadotropin in gonadal associated with syndrome, narcan and opioid
1) Confidence 0.51 Published 1985 Journal Psychoneuroendocrinology Section Abstract Doc Link 3933025 Disease Relevance 0.17 Pain Relevance 0.34
The results demonstrate that in castrated subjects who lack gonadal steroids and in normal subjects with blocked estrogen receptors there is a reduced opioid inhibitory tone on gonadotropin secretion.
Negative_regulation (reduced) of Localization (secretion) of gonadotropin in gonadal associated with opioid
2) Confidence 0.49 Published 1983 Journal Fertil. Steril. Section Abstract Doc Link 6317469 Disease Relevance 0 Pain Relevance 0.50
Opioid antagonists inhibit the release of hCG due to their reversal of the stimulation caused by endogenous opioid peptides.
Negative_regulation (inhibit) of Localization (release) of hCG associated with antagonist, endogenous opioid and opioid
3) Confidence 0.48 Published 1991 Journal Life Sci. Section Abstract Doc Link 1652048 Disease Relevance 0 Pain Relevance 1.03
During the CC test a decrease of gonadotropin secretion, chronically and quantitatively identical for both group, was found; while on the following test days an increase was noted, which was more accelerated in male recipients.
Negative_regulation (decrease) of Localization (secretion) of gonadotropin
4) Confidence 0.45 Published 1996 Journal Ren Fail Section Abstract Doc Link 8948525 Disease Relevance 0.25 Pain Relevance 0.06
OBJECTIVE: Opioids generally suppress gonadotropin secretion.
Negative_regulation (suppress) of Localization (secretion) of gonadotropin associated with opioid
5) Confidence 0.43 Published 1992 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 1471698 Disease Relevance 0 Pain Relevance 0.27
Endogenous catecholamines augment the inhibitory effect of opioids on luteinizing hormone secretion during the midluteal phase.
Negative_regulation (effect) of Localization (secretion) of luteinizing hormone associated with catecholamine, narcan and opioid
6) Confidence 0.40 Published 1993 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 7903508 Disease Relevance 0 Pain Relevance 0.34
CONCLUSION: Endogenous catecholamines augment the inhibitory effect of opioids on luteinizing hormone secretion during the midluteal phase in normal cycling women.


Negative_regulation (effect) of Localization (secretion) of luteinizing hormone
7) Confidence 0.40 Published 1993 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 7903508 Disease Relevance 0 Pain Relevance 0
A majority of work in this field has focused on non-surgically destroying the testes or obstructing the epididymis, and suppressing gonadotropin secretion or inducing immune responses to reproductive hormones or sperm-specific antigens.
Negative_regulation (suppressing) of Localization (secretion) of gonadotropin in sperm
8) Confidence 0.37 Published 2008 Journal Anim. Reprod. Sci. Section Abstract Doc Link 18191924 Disease Relevance 0.16 Pain Relevance 0.12
This was followed by a delayed increase in hCG secretion.
Negative_regulation (delayed) of Localization (secretion) of hCG
9) Confidence 0.35 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1682338 Disease Relevance 0 Pain Relevance 0.81
Selective defect in gonadotrophin secretion in patients with autonomic failure.
Negative_regulation (defect) of Neg (failure) Localization (secretion) of gonadotrophin in autonomic associated with narcan
10) Confidence 0.32 Published 1989 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 2512037 Disease Relevance 0 Pain Relevance 0.30
The authors carried out three sequential studies which demonstrated that heroin use in man results in acute suppression of luteinizing hormone (LH) release from the pituitary followed by a secondary drop in plasma testosterone levels.
Negative_regulation (suppression) of Localization (release) of luteinizing hormone in plasma associated with opiate addiction
11) Confidence 0.29 Published 1980 Journal Am J Psychiatry Section Abstract Doc Link 6774622 Disease Relevance 0.19 Pain Relevance 0.34
GnRH antagonist inhibited both opioids and GnRH stimulation of hCG release from trophoblast tissue.
Negative_regulation (inhibited) of Localization (release) of hCG associated with antagonist and opioid
12) Confidence 0.27 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8114013 Disease Relevance 0 Pain Relevance 0.78
Antagonists inhibited the release of hCG and GnRH and totally reversed the effect of agonists, i.e., their effect is kappa receptor mediated.
Negative_regulation (inhibited) of Localization (release) of hCG associated with antagonist and agonist
13) Confidence 0.27 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8114013 Disease Relevance 0 Pain Relevance 0.77
Both the protein kinase C (PKC) specific activator 1-deoyl-2-acetyl-sn-glycerol (OAG) and the PKC non-specific activator phorbol-12-myristate-13-acetate (PMA) had a stimulatory effect on hCG secretion, while the PKC inhibitor, 1-(5-isoquinolinylsulfonyl)-2-methyl-piperazine (H7) diminished the hCG secretion stimulated by NE.
Negative_regulation (diminished) of Localization (secretion) of hCG associated with kinase c
14) Confidence 0.25 Published 1993 Journal Placenta Section Abstract Doc Link 8153089 Disease Relevance 0 Pain Relevance 0.60
High naloxone concentrations significantly decreased both hCG and progesterone secretion induced by high doses of hGH.
Negative_regulation (decreased) of Localization (secretion) of hCG associated with narcan
15) Confidence 0.23 Published 1995 Journal Gynecol. Endocrinol. Section Abstract Doc Link 7502693 Disease Relevance 0 Pain Relevance 0.45
Data presented demonstrated that the stimulation of hCG secretion by the kappa-selective agonist U69,593 was abolished in presence of either EGTA or the calcium channel blocker nifedipine.
Negative_regulation (abolished) of Localization (secretion) of hCG associated with calcium channel and agonist
16) Confidence 0.22 Published 1998 Journal J. Mol. Neurosci. Section Abstract Doc Link 9770647 Disease Relevance 0 Pain Relevance 0.48
Tonic, pulsatile gonadotropin secretion is inhibited by stress and by administered morphine, but morphine does not block the estrogen-induced preovulatory surge in primates.
Negative_regulation (inhibited) of Localization (secretion) of gonadotropin associated with stress and morphine
17) Confidence 0.21 Published 1990 Journal Int. J. Fertil. Section Abstract Doc Link 1968447 Disease Relevance 0.49 Pain Relevance 0.29
Corticotropin-releasing factor (CRF) does interact with gonadotropin-releasing hormone (GnRH)-producing neurons, probably through an opioidergic pathway, suppressing gonadotropin secretion.
Negative_regulation (suppressing) of Localization (secretion) of gonadotropin in neurons
18) Confidence 0.21 Published 1990 Journal Int. J. Fertil. Section Abstract Doc Link 1968447 Disease Relevance 0.45 Pain Relevance 0.26
These results suggest that an acute increase in GABA-ergic tone may inhibit gonadotropin secretion in the estrogen-deprived state, or when endogenous opioid inhibition is blocked in postmenopausal women on estrogens, as well as during the luteal phase of the menstrual cycle.
Negative_regulation (inhibit) of Localization (secretion) of gonadotropin associated with gaba and endogenous opioid
19) Confidence 0.21 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8675571 Disease Relevance 0 Pain Relevance 0.47
It is likely that the secretion of i-hCG itself was decreased due to derangement of trophoblastic division in patients with ectopic pregnancy.
Negative_regulation (decreased) of Localization (secretion) of i-hCG associated with ectopic pregnancy
20) Confidence 0.21 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782204 Disease Relevance 0.44 Pain Relevance 0

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