INT7116

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 1.20
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Rab8a) cytoplasmic membrane-bounded vesicle (Rab8a) plasma membrane (Rab8a)
cytoplasm (Rab8a)
Anatomy Link Frequency
PBL 2
pineal glands 1
Rab8a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
beta blocker 6 98.06 Very High Very High Very High
dexamethasone 7 97.16 Very High Very High Very High
antagonist 23 95.52 Very High Very High Very High
Serotonin 12 95.32 Very High Very High Very High
narcan 6 92.40 High High
noradrenaline 2 91.88 High High
Clonidine 2 91.16 High High
agonist 4 90.76 High High
Catecholamine 2 88.12 High High
Opioid 6 69.44 Quite High
Disease Link Frequency Relevance Heat
Stress 5 98.74 Very High Very High Very High
Sleep Initiation And Maintenance Disorders 2 91.76 High High
Obesity 16 89.44 High High
Hepatocellular Cancer 8 89.04 High High
Body Weight 2 82.72 Quite High
Sleep Disorders 20 81.36 Quite High
Metabolic Syndrome 43 75.28 Quite High
Syndrome 1 67.72 Quite High
INFLAMMATION 11 54.48 Quite High
Hyperplasia 3 52.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since melatonin (MEL) reportedly has stress-protective effects on several immune functions, and since the release of MEL from the pineal gland is inhibited by beta-blockade, we tested the effect of MEL substitution on T- and B-cell mitogen responses of PBL in rats treated with two s.c. implanted retard tablets containing noradrenaline (NA) and propranolol.
Localization (release) of MEL in PBL associated with stress and noradrenaline
1) Confidence 0.70 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8765337 Disease Relevance 0.10 Pain Relevance 0.17
It is concluded that endogenous MEL effectively protects rat PBL from adrenergic immunosuppression, and that beta-blockers enhance the immunosuppressive property of alpha 2-adrenergic agents via blocking the night-time release of MEL.
Localization (release) of MEL in PBL associated with beta blocker
2) Confidence 0.61 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8765337 Disease Relevance 0.06 Pain Relevance 0.32
With regard to kinetic characteristics, the effect of DSIP (10(-4) M) on MEL release was faster and of shorter duration than the effect of ISO (10(-6) M; 2 and 4 h, respectively).
Localization (release) of MEL
3) Confidence 0.60 Published 1992 Journal Biol. Signals Section Abstract Doc Link 1339175 Disease Relevance 0 Pain Relevance 0.27
ISO stimulated MEL secretion and concomitantly decreased 5-HT release.
Localization (secretion) of MEL
4) Confidence 0.60 Published 1992 Journal Biol. Signals Section Abstract Doc Link 1339175 Disease Relevance 0 Pain Relevance 0.20
The stimulatory effect of DSIP on MEL secretion was dose dependent between 5 x 10(-6) and 10(-4) M, whereas the minimal effective concentration of DSIP on 5-ML secretion was higher than 10(-5) M.
Localization (secretion) of MEL
5) Confidence 0.53 Published 1992 Journal Biol. Signals Section Abstract Doc Link 1339175 Disease Relevance 0 Pain Relevance 0.09
The DSIP-stimulated release of MEL was not significantly altered when the pineal glands were treated with 10(-5) M propranolol (a beta-adrenergic antagonist), 10(-5) M prazosin (an alpha 1-adrenergic antagonist) or 10(-5) M naloxone (an opioidergic antagonist).
Localization (release) of MEL in pineal glands associated with antagonist and narcan
6) Confidence 0.53 Published 1992 Journal Biol. Signals Section Abstract Doc Link 1339175 Disease Relevance 0 Pain Relevance 0.33
At 10(-4) M, DSIP potentiated the ISO-induced increase of MEL secretion.
Localization (secretion) of MEL
7) Confidence 0.53 Published 1992 Journal Biol. Signals Section Abstract Doc Link 1339175 Disease Relevance 0 Pain Relevance 0.31
The effect of DSIP (10(-4) M) was compared to the effect of isoproterenol (ISO, 10(-6) M) on MEL and 5-HT release.
Localization (release) of MEL
8) Confidence 0.46 Published 1992 Journal Biol. Signals Section Abstract Doc Link 1339175 Disease Relevance 0 Pain Relevance 0.20
To further investigate the peroxisomal localization of Rab8, Rab8a was cloned as 5?
Spec (investigate) Localization (localization) of Rab8
9) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0.09 Pain Relevance 0
To further investigate the peroxisomal localization of Rab8, Rab8a was cloned as 5?
Spec (investigate) Localization (localization) of Rab8a
10) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0.09 Pain Relevance 0
However, when added simultaneously with MEL, LEP release was increased by a robust 250% [44].
Localization (release) of MEL
11) Confidence 0.03 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 0.86 Pain Relevance 0.08

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