INT71189

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 24
Total Number 25
Disease Relevance 11.39
Pain Relevance 11.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
Anatomy Link Frequency
liver 4
hepatocytes 1
Mouse 1
Cyp1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
halothane 3 99.32 Very High Very High Very High
Paracetamol 162 99.00 Very High Very High Very High
Inflammation 13 95.52 Very High Very High Very High
cva 3 95.36 Very High Very High Very High
agonist 7 86.56 High High
Infliximab 1 79.20 Quite High
antagonist 6 76.56 Quite High
Potency 1 72.64 Quite High
sSRI 1 70.00 Quite High
antidepressant 1 66.08 Quite High
Disease Link Frequency Relevance Heat
Hepatitis 12 99.68 Very High Very High Very High
Sprains And Strains 45 99.48 Very High Very High Very High
Hepatotoxicity 38 99.08 Very High Very High Very High
Nicotine Addiction 69 97.56 Very High Very High Very High
Injury 27 97.52 Very High Very High Very High
Renal Cancer 1 97.16 Very High Very High Very High
Targeted Disruption 48 96.28 Very High Very High Very High
INFLAMMATION 12 95.52 Very High Very High Very High
Hemorrhage 3 95.36 Very High Very High Very High
Toxicity 25 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differences in caffeine 3-demethylation activity among inbred mouse strains: a comparison of hepatic Cyp1a2 gene expression between two inbred strains.
Gene_expression (expression) of Cyp1a2 associated with sprains and strains
1) Confidence 0.78 Published 1997 Journal Fundam Appl Toxicol Section Title Doc Link 9441719 Disease Relevance 1.02 Pain Relevance 0.08
The striking differences observed between the APN and C3H/HeJ mice suggest that these strains may be suitable for a genetic analysis of the regulation of the basal expression of CYP1A2, a key enzyme in procarcinogen activation.
Gene_expression (expression) of CYP1A2 associated with sprains and strains
2) Confidence 0.78 Published 1997 Journal Fundam Appl Toxicol Section Abstract Doc Link 9441719 Disease Relevance 1.00 Pain Relevance 0.06
The co-segregation of elevated basal Cyp1a1 and CYP1a2 gene expression levels in animals selected for susceptibility to acetaminophen-induced hepatotoxicity suggested a common heritable basis for regulation of basal expression of both of these CYP1A isoforms.
Gene_expression (expression) of CYP1a2 associated with paracetamol and hepatotoxicity
3) Confidence 0.77 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.17 Pain Relevance 0.39
Increased basal expression of hepatic Cyp1a1 and Cyp1a2 genes in inbred mice selected for susceptibility to acetaminophen-induced hepatotoxicity.
Gene_expression (expression) of Cyp1a2 associated with paracetamol and hepatotoxicity
4) Confidence 0.77 Published 1997 Journal Pharmacogenetics Section Title Doc Link 9295056 Disease Relevance 0.19 Pain Relevance 0.44
To test the combined roles of CYP1A2 and CYP2E1 in an intact animal model, a double-null mouse line lacking functional expression of CYP1A2 and CYP2E1 was produced by cross-breeding Cyp1a2-/- mice with Cyp2e1-/- mice.
Gene_expression (expression) of CYP1A2
5) Confidence 0.76 Published 1998 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9772215 Disease Relevance 0.48 Pain Relevance 0.40
The pretreatment regimen resulted in hepatic changes including: centrilobular localization of 3-(cysteine-S-yl)APAP protein adducts, selective down-regulation of cytochrome P4502E1 (CYP2E1) and CYP1A2 that produced the toxic metabolite, N-acetyl-p-benzoquinone imine, higher levels of reduced glutathione (GSH), centrilobular inflammation, and a fourfold increase in hepatocellular proliferation.
Gene_expression (produced) of CYP1A2 associated with paracetamol and inflammation
6) Confidence 0.71 Published 1999 Journal Hepatology Section Abstract Doc Link 9918922 Disease Relevance 0.26 Pain Relevance 0.92
Our finding that APAP hepatotoxicity was decreased in PXR(-/-) mice indicates that PXR is an important modulator of APAP hepatotoxicity, through positive modulation of constitutive CYP1A2 expression and possibly through increased APAP absorption.
Gene_expression (expression) of CYP1A2 associated with paracetamol and hepatotoxicity
7) Confidence 0.71 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 16141365 Disease Relevance 0.52 Pain Relevance 0.93
Hepatic Cyp1a2 expression was compared between APN and C3H/HeJ males.
Gene_expression (expression) of Cyp1a2 associated with sprains and strains
8) Confidence 0.68 Published 1997 Journal Fundam Appl Toxicol Section Abstract Doc Link 9441719 Disease Relevance 1.15 Pain Relevance 0.09
In vivo caffeine 3-demethylation, which is associated with CYP1A2 activity, co-segregated with acetaminophen susceptibility and showed a significant positive correlation (r = 0.626, p < 0.005) with CYP1A2 mRNA expression in animals from both the susceptible and nonsusceptible groups.
Gene_expression (expression) of CYP1A2 associated with paracetamol
9) Confidence 0.67 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.16 Pain Relevance 0.45
Furthermore, the expression of two cytochrome P450 enzymes, CYP1A2 and CYP2E1, was almost completely abolished in livers from hepatocyte-specific beta-catenin knockout mice.
Gene_expression (expression) of CYP1A2 in livers associated with targeted disruption
10) Confidence 0.65 Published 2006 Journal Hepatology Section Abstract Doc Link 16557553 Disease Relevance 0.58 Pain Relevance 0.09
Mouse lines lacking the P450s CYP1A1, CYP1A2, CYP1B1 and CYP2E1, microsomal epoxide hydrolase (mEH), NADPH:quinone oxidoreductase and the glutathione S-transferase P1 have no deleterious phenotypes, indicating that these enzymes are not required for mammalian development and physiological homeostasis.
Neg (lacking) Gene_expression (lacking) of CYP1A2 in Mouse
11) Confidence 0.63 Published 2001 Journal Toxicol. Lett. Section Abstract Doc Link 11323178 Disease Relevance 0.30 Pain Relevance 0.06
Lower basal Cyp1a2 mRNA levels and lower expression of Cyp1a2 and Cyp3a11 mRNAs after APAP dosing were also observed in females compared with males.
Gene_expression (expression) of Cyp1a2 associated with paracetamol
12) Confidence 0.63 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16611625 Disease Relevance 0.43 Pain Relevance 1.10
Results from this work demonstrate that, in the absence of CYP1A2, phenacetin is more toxic than in controls.
Neg (absence) Gene_expression (absence) of CYP1A2
13) Confidence 0.60 Published 1999 Journal Toxicol. Sci. Section Abstract Doc Link 10445756 Disease Relevance 0.64 Pain Relevance 0.07
Immunoblot analysis of microsomal proteins showed that rutaecarpine-treatment increased the protein levels of CYP1A1 and CYP1A2 in the liver, whereas hepatic level of CYP3A-immunoreacted protein was not affected by rutaecarpine.
Gene_expression (levels) of CYP1A2 in liver
14) Confidence 0.58 Published 2001 Journal Life Sci. Section Abstract Doc Link 11787945 Disease Relevance 0.12 Pain Relevance 0.06
Results showed that the catalytic activity and polypeptide levels of CYP1A2, CYP2E1, and CYP3A were unchanged in the treatment groups compared to vehicle and untreated controls.
Gene_expression (levels) of CYP1A2
15) Confidence 0.58 Published 2001 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 11437634 Disease Relevance 0.29 Pain Relevance 0.76
Expression of CYP1A2, CYP2C8, CYP2C18, CYP2C19, CYP2D6, CYP3A7, CYP4A11, FMO1, and FMO3 was below the limit of detection (LOD) in all investigated samples (data not shown).


Spec (investigated) Gene_expression (Expression) of CYP1A2
16) Confidence 0.56 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.48 Pain Relevance 0
Lower basal Cyp1a2 mRNA levels and lower expression of Cyp1a2 and Cyp3a11 mRNAs after APAP dosing were also observed in females compared with males.
Gene_expression (expression) of Cyp1a2 associated with paracetamol
17) Confidence 0.55 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16611625 Disease Relevance 0.43 Pain Relevance 1.10
Immunoblot analyses showed that methanol extract increased the levels of CYP1A1, CYP1A2, CYP2B-, and GSTYb-immunoreactive proteins.
Gene_expression (levels) of CYP1A2
18) Confidence 0.55 Published 2002 Journal Life Sci. Section Abstract Doc Link 12106592 Disease Relevance 0.11 Pain Relevance 0.06
Finally, when given 12 h before APAP challenge, IL-1 alpha repressed the intrahepatic expression of CYP1A2, CYP2E1, and CYP3A11, eventually reducing APAP-induced liver injury, along with reduction in APAP adducts.
Gene_expression (expression) of CYP1A2 in liver associated with paracetamol and injury
19) Confidence 0.52 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19002106 Disease Relevance 0.45 Pain Relevance 1.08
Moreover, the amounts of a major APAP adduct (selenium-binding protein), an indicator of NAPQI generation from APAP, was significantly lower in IL-1ra KO mice than WT mice with depressed intrahepatic expression of CYP1A2, CYP2E1, and CYP3A11, the enzymes crucially involved in NAPQI generation from APAP.
Gene_expression (expression) of CYP1A2 associated with paracetamol
20) Confidence 0.52 Published 2009 Journal Lab. Invest. Section Abstract Doc Link 19002106 Disease Relevance 0.21 Pain Relevance 1.05

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