INT7125

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Context Info
Confidence 0.78
First Reported 1992
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 47
Total Number 49
Disease Relevance 42.12
Pain Relevance 7.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PLA2G2A) extracellular region (PLA2G2A) endoplasmic reticulum (PLA2G2A)
Anatomy Link Frequency
brains 3
epithelium 3
tears 3
plasma 2
macrophage 2
PLA2G2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 130 99.72 Very High Very High Very High
Inflammation 1103 99.68 Very High Very High Very High
rheumatoid arthritis 28 98.28 Very High Very High Very High
Angina 26 97.96 Very High Very High Very High
cytokine 191 97.92 Very High Very High Very High
Pain 14 97.54 Very High Very High Very High
ischemia 10 97.08 Very High Very High Very High
cINOD 107 94.16 High High
addiction 4 92.84 High High
Inflammatory response 71 92.40 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 13 99.88 Very High Very High Very High
Disease 837 99.84 Very High Very High Very High
Atherosclerosis 422 99.84 Very High Very High Very High
Conjunctivitis 343 99.84 Very High Very High Very High
INFLAMMATION 1271 99.68 Very High Very High Very High
Pancreatic Ductal Carcinoma 6 99.60 Very High Very High Very High
Heart Rate Under Development 266 99.52 Very High Very High Very High
Conjunctiva Disease 259 99.48 Very High Very High Very High
Brain Injury 10 99.32 Very High Very High Very High
Cancer 141 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results show that the recombinant PLA2 can be efficiently expressed and purified in sufficient quantities to characterize the enzyme active site, to aid in the rational development of PLA2 inhibitors as potential anti-inflammatory drugs, and to investigate further the role of PLA2 in inflammatory disease.
Gene_expression (expressed) of PLA2 associated with inflammation, cinod and disease
1) Confidence 0.78 Published 1992 Journal J. Mol. Recognit. Section Abstract Doc Link 1339483 Disease Relevance 0.40 Pain Relevance 0.22
Although previous studies have demonstrated an increase in mRNA expression [26] and immunoreactivity of cPLA2 in AD brains [26-28], studies to relate sPLA2-IIA expression with AD have been lacking.
Gene_expression (expression) of sPLA2 in brains associated with disease
2) Confidence 0.77 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 1.73 Pain Relevance 0.27
These procedures produced sPLA2-IIA immunoreactivity in dark blue color and GFAP in brown color.
Gene_expression (produced) of sPLA2
3) Confidence 0.77 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.23 Pain Relevance 0
The increase in sPLA2-IIA expression in AD hippocampus, but not in AD cerebellum, is in agreement with the neuropathological observations that reactive astrocytes are increasingly associated with pathology in hippocampus and cortex, whereas diffuse amyloid deposits and limited astrocyte activation are found in cerebellum [3,42].
Gene_expression (expression) of sPLA2 in astrocytes associated with hippocampus, disease and amyloid plaque
4) Confidence 0.77 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.95 Pain Relevance 0.31
Furthermore, the expression of group II PLA2 was significantly higher in the tumor with larger amount of interstitial tissue than in that with smaller amounts of interstitial tissue.
Gene_expression (expression) of PLA2 associated with cancer
5) Confidence 0.76 Published 1993 Journal Int. J. Pancreatol. Section Abstract Doc Link 8384235 Disease Relevance 1.20 Pain Relevance 0.13
These results suggest that expression of group II PLA2 in human pancreatic ductal carcinomas is possibly involved in the proliferation of interstitial tissue directly or indirectly through prostaglandin production.
Gene_expression (expression) of PLA2 associated with pancreatic ductal carcinoma
6) Confidence 0.76 Published 1993 Journal Int. J. Pancreatol. Section Abstract Doc Link 8384235 Disease Relevance 0.97 Pain Relevance 0.07
Moreover, HDL- and ApoA-I-catabolism as well as HDL-cholesteryl ester tissue uptake were significantly enhanced under conditions of sPLA2-IIA overexpression even in the absence of inflammatory preconditions (Tietge et al 2000).
Gene_expression (overexpression) of sPLA2-IIA associated with inflammation and disorder of lipid metabolism
7) Confidence 0.75 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.99 Pain Relevance 0.14
This stimulation resulted in enhanced sPLA2-IIA protein expression and sPLA2-IIA activity.
Gene_expression (expression) of sPLA2-IIA
8) Confidence 0.75 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.61 Pain Relevance 0.07
Increased plasma levels of sPLA2-IIA predicted recurrent coronary events, mainly revascularization procedures, independently of other established risk factors (Kugiyama et al 2000).
Gene_expression (levels) of sPLA2-IIA in plasma
9) Confidence 0.75 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 1.18 Pain Relevance 0.25
Intravenous or oral administration of LY315920 to transgenic mice expressing the human sPLA2 protein inhibited serum sPLA2 activity in a dose-related manner over a 4-h time course.
Gene_expression (expressing) of sPLA2 associated with targeted disruption
10) Confidence 0.74 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027849 Disease Relevance 0.17 Pain Relevance 0.18
The cDNA encoding the human PLA2 was subcloned into an expression vector and subsequently transfected into Chinese hamster ovary (CHO) cells.
Gene_expression (transfected) of PLA2 in CHO
11) Confidence 0.67 Published 1992 Journal J. Mol. Recognit. Section Abstract Doc Link 1339483 Disease Relevance 0.19 Pain Relevance 0.07
In PC12 cells, lysophospholipids produced by sPLA2-IIA were shown to alter neurite outgrowth [58].
Gene_expression (produced) of sPLA2 in neurite
12) Confidence 0.67 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.87 Pain Relevance 0.27
RT-PCR indicated very low sPLA2-IIA mRNA expression in control and IFN?
Gene_expression (expression) of sPLA2
13) Confidence 0.67 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.58 Pain Relevance 0.14
The phospholipases A2 (PLA2) belong to a family of enzymes that are widely expressed in many types of mammalian cells [17].
Gene_expression (expressed) of PLA2
14) Confidence 0.67 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.97 Pain Relevance 0.18
The results showed that sPLA2 was more common (25/53, 47%) than cPLA2 (13/53, 25%). sPLA2 and cPLA2 were simultaneously present in 13 of 53 samples (25%).
Gene_expression (present) of sPLA2
15) Confidence 0.67 Published 1998 Journal Eur Spine J Section Abstract Doc Link 9840472 Disease Relevance 0.57 Pain Relevance 0.18
Fifty-three disc prolapses obtained at disc operations were analyzed by immunohistochemistry, using anti-human monoclonal antibodies to sPLA2 and cPLA2, respectively.
Spec (analyzed) Gene_expression (using) of sPLA2 associated with prolapse
16) Confidence 0.67 Published 1998 Journal Eur Spine J Section Abstract Doc Link 9840472 Disease Relevance 0.60 Pain Relevance 0.17
This stimulation resulted in enhanced sPLA2-IIA protein expression and sPLA2-IIA activity.
Gene_expression (expression) of sPLA2-IIA
17) Confidence 0.65 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.60 Pain Relevance 0.06
In this way, catalytic inactive sPLA2-IIA was shown to promote COX-2 expression in mast cells (Tada et al 1998).
Gene_expression (expression) of sPLA2-IIA in mast cells
18) Confidence 0.65 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 1.08 Pain Relevance 0.19
The most predisposing patterns for this combination, presented in Table 2, combine genotypes 1 and 2 for PTGS1 c.639C>A, IL8 c.-352T>A, and MTHFR c.1286A>C, and 0 for PLA2G2A c.435+230C>T and PPARG c.1431C>T.
Gene_expression (c.435+230C>T) of PLA2G2A
19) Confidence 0.61 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.37 Pain Relevance 0
Local inflammation and pain are important characteristics of snakebite envenomations inflicted by viperid and crotalid species, whose venoms are rich sources of myotoxic PLA2s.
Gene_expression (sources) of PLA2s associated with pain and inflammation
20) Confidence 0.60 Published 2003 Journal Toxicon Section Abstract Doc Link 15019493 Disease Relevance 0.77 Pain Relevance 0.34

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