INT7127

Context Info Confidence 0.69 First Reported 1992 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 16 Total Number 17 Disease Relevance 17.11 Pain Relevance 2.63

extracellular space (PLA2G2A) extracellular region (PLA2G2A) endoplasmic reticulum (PLA2G2A)

Anatomy Link Frequency plasma 4 brains 4 tears 2 neuronal 2 astrocytes 2 PLA2G2A (Homo sapiens)

Pain Link Frequency Relevance Heat Hippocampus 65 99.72 Inflammation 382 99.04 Angina 14 98.64 ischemia 5 97.08 cytokine 70 91.68 Arthritis 5 88.84 Inflammatory response 20 82.56 Kinase C 7 79.60 Glutamate receptor 5 75.20 Neuritis 5 52.88

Disease Link Frequency Relevance Heat Disease 374 99.84 Conjunctivitis 98 99.84 Conjunctiva Disease 74 99.68 Brain Injury 5 99.56 Heart Rate Under Development 76 99.52 INFLAMMATION 431 99.04 Cv General 3 Under Development 14 98.64 Colon Cancer 198 98.58 Disorder Of Lipid Metabolism 77 98.38 Injury 22 97.64

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The increase in sPLA2-IIA expression in AD hippocampus, but not in AD cerebellum, is in agreement with the neuropathological observations that reactive astrocytes are increasingly associated with pathology in hippocampus and cortex, whereas diffuse amyloid deposits and limited astrocyte activation are found in cerebellum [3,42].

Positive_regulation (increase) of Gene_expression (expression) of sPLA2 in astrocytes associated with hippocampus, disease and amyloid plaque

1) Confidence 0.69 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.95 Pain Relevance 0.31

Increased plasma levels of sPLA2-IIA predicted recurrent coronary events, mainly revascularization procedures, independently of other established risk factors (Kugiyama et al 2000).

Positive_regulation (Increased) of Gene_expression (levels) of sPLA2-IIA in plasma

2) Confidence 0.67 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 1.19 Pain Relevance 0.25

Moreover, HDL- and ApoA-I-catabolism as well as HDL-cholesteryl ester tissue uptake were significantly enhanced under conditions of sPLA2-IIA overexpression even in the absence of inflammatory preconditions (Tietge et al 2000).

Positive_regulation (overexpression) of Gene_expression (overexpression) of sPLA2-IIA associated with inflammation and disorder of lipid metabolism

3) Confidence 0.67 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.99 Pain Relevance 0.14

This stimulation resulted in enhanced sPLA2-IIA protein expression and sPLA2-IIA activity.

Positive_regulation (enhanced) of Gene_expression (expression) of sPLA2-IIA

4) Confidence 0.67 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.61 Pain Relevance 0.07

This stimulation resulted in enhanced sPLA2-IIA protein expression and sPLA2-IIA activity.

Positive_regulation (resulted) of Gene_expression (expression) of sPLA2-IIA

5) Confidence 0.67 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.61 Pain Relevance 0.07

The cDNA encoding the human PLA2 was subcloned into an expression vector and subsequently transfected into Chinese hamster ovary (CHO) cells.

Positive_regulation (transfected) of Gene_expression (transfected) of PLA2 in CHO

6) Confidence 0.50 Published 1992 Journal J. Mol. Recognit. Section Abstract Doc Link 1339483 Disease Relevance 0.19 Pain Relevance 0.07

RT-PCR indicated very low sPLA2-IIA mRNA expression in control and IFN?

Positive_regulation (indicated) of Gene_expression (expression) of sPLA2

7) Confidence 0.50 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.58 Pain Relevance 0.14

Using a new approach with SBTI as an internal standard, we showed that part of the major tear protein components increased in tears of AC patients and further demonstrated that the sPLA2-IIa expression is increased in the AC patients.

Positive_regulation (increased) of Gene_expression (expression) of sPLA2-IIa in tears associated with conjunctiva disease

8) Confidence 0.49 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965574 Disease Relevance 1.29 Pain Relevance 0

Our finding of increased sPLA2-IIa expression in SAC and PAC patients is in agreement with the study by Chen et al., which demonstrated that sPLA2-IIa is an inflammatory mediator when the ocular surface is compromised [21].

Positive_regulation (increased) of Gene_expression (expression) of sPLA2-IIa associated with heart rate under development, conjunctivitis and inflammation

9) Confidence 0.49 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965574 Disease Relevance 1.38 Pain Relevance 0.11

This stimulation resulted in enhanced sPLA2-IIA protein expression and sPLA2-IIA activity.

Positive_regulation (resulted) of Gene_expression (expression) of sPLA2-IIA

10) Confidence 0.48 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.61 Pain Relevance 0.07

This stimulation resulted in enhanced sPLA2-IIA protein expression and sPLA2-IIA activity.

Positive_regulation (enhanced) of Gene_expression (expression) of sPLA2-IIA

11) Confidence 0.48 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.61 Pain Relevance 0.07

In this report, we provide data demonstrating up-regulation of sPLA2-IIA mRNA and protein expression in reactive astrocytes in AD brains as compared to age-matched non-demented (ND) control brains.

Positive_regulation (regulation) of Gene_expression (expression) of sPLA2 in brains associated with disease

12) Confidence 0.46 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 1.91 Pain Relevance 0.32

However, studies with rat models of brain injury have demonstrated an increase in sPLA2-IIA expression associated with different forms of neuronal insults, including cerebral ischemia [34,35] as well as other types of neuronal injuries [36,37].

Positive_regulation (increase) of Gene_expression (expression) of sPLA2 in neuronal associated with cv general 4 under development, ischemia, injury and brain injury

13) Confidence 0.46 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 1.86 Pain Relevance 0.31

This study demonstrates for the first time an increase in protein expression of sPLA2-IIA in GFAP-positive astrocytes in AD brains as compared to ND brains.

Positive_regulation (increase) of Gene_expression (expression) of sPLA2 in brains associated with disease

14) Confidence 0.46 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 1.30 Pain Relevance 0.35

Moreover, increased plasma levels of sPLA2 in stable patients undergoing percutaneous coronary angioplasty (PCI) also provide independent prognostic information over other classic cardiovascular risk factors and clinical covariables (Liu et al 2003).

Positive_regulation (increased) of Gene_expression (levels) of sPLA2 in plasma

15) Confidence 0.45 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 1.08 Pain Relevance 0.28

However, the contribution of PLA2G2A to sporadic CRC predisposition cannot be excluded, and it has been suggested that the increase in PLA2G2A expression could cause the accumulation of arachidonic acid, a molecule likely to have pro-apoptotic properties [41].

Positive_regulation (increase) of Gene_expression (expression) of PLA2G2A associated with colon cancer and apoptosis

16) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.95 Pain Relevance 0.04

A hypothesis for the protective role of variant c.435+230T might therefore be its enhancement of PLA2G2A expression.

Positive_regulation (enhancement) of Gene_expression (expression) of PLA2G2A

17) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.99 Pain Relevance 0.05

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