INT71322

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Context Info
Confidence 0.33
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.97
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprd1) plasma membrane (Oprd1) cytoplasm (Oprd1)
signal transducer activity (Oprd1)
Anatomy Link Frequency
thalamus 4
GPI 2
Oprd1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 20 100.00 Very High Very High Very High
agonist 16 100.00 Very High Very High Very High
Thalamus 2 99.04 Very High Very High Very High
antagonist 5 95.08 Very High Very High Very High
Morphine 4 93.20 High High
Dopamine 1 92.40 High High
Kappa opioid receptor 10 88.64 High High
Antinociceptive 6 86.08 High High
antinociception 4 85.60 High High
Opioid 6 80.88 Quite High
Disease Link Frequency Relevance Heat
Tics 10 99.64 Very High Very High Very High
Targeted Disruption 5 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under these conditions, repeated s.c. injection of (-)U-50,488H significantly enhanced both mu- and delta-opioid receptor agonist-stimulated [35S]GTPgammaS binding in the membrane of the thalamus.
Positive_regulation (agonist-stimulated) of delta-opioid receptor Binding (binding) of in thalamus associated with agonist, thalamus and opioid receptor
1) Confidence 0.33 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975677 Disease Relevance 0 Pain Relevance 1.36
Under these conditions, repeated s.c. injection of (-)U-50,488H significantly enhanced both mu- and delta-opioid receptor agonist-stimulated [35S]GTPgammaS binding in the membrane of the thalamus.
Positive_regulation (enhanced) of delta-opioid receptor Binding (binding) of in thalamus associated with agonist, thalamus and opioid receptor
2) Confidence 0.33 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975677 Disease Relevance 0 Pain Relevance 1.37
N-Me-(9) and N,N-Me2-Dmt-Tic-Ala-OH (15) also augmented delta opioid receptor binding, such that 15 demonstrated high affinity (Ki delta = 0.0755 nM) and selectivity (Ki mu/Ki delta = 20132) with exceptional antagonist activity on MVD (pA2 = 9.6; Ke = 0.22 nM) and weak antagonism on GPI (pA2 = 5.8; Ke = 1.58 microM; GPI/MVD = 1:7180).
Positive_regulation (augmented) of delta opioid receptor Binding (binding) of in GPI associated with tics, antagonist and opioid receptor
3) Confidence 0.17 Published 1997 Journal J. Med. Chem. Section Abstract Doc Link 9301674 Disease Relevance 0.61 Pain Relevance 0.48
A significant increase in delta-opioid receptor (delta-OR) ligand binding was found in mu-OR knockout mice.
Positive_regulation (increase) of delta-opioid receptor Binding (binding) of associated with targeted disruption and opioid receptor
4) Confidence 0.14 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17139685 Disease Relevance 0.36 Pain Relevance 0.65

General Comments

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