INT71515

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Context Info
Confidence 0.38
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.28
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CHPT1) lipid metabolic process (CHPT1)
Anatomy Link Frequency
amygdala 1
CHPT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 18 99.68 Very High Very High Very High
amygdala 81 98.44 Very High Very High Very High
Paracetamol 1 90.76 High High
anesthesia 1 87.92 High High
Pain 40 85.52 High High
dexamethasone 1 83.00 Quite High
aspirin 1 81.20 Quite High
transdermal 1 67.80 Quite High
abdominal pain 1 63.44 Quite High
Central nervous system 1 49.68 Quite Low
Disease Link Frequency Relevance Heat
Sleep Disorders 1 99.80 Very High Very High Very High
Diarrhoea 3 99.64 Very High Very High Very High
Poisoning 2 99.54 Very High Very High Very High
Metastasis 30 99.36 Very High Very High Very High
Nicotine Addiction 3 98.92 Very High Very High Very High
Neutropenia 2 98.88 Very High Very High Very High
Vomiting 2 98.24 Very High Very High Very High
Fatigue 1 86.00 High High
Appetite Loss 1 85.48 High High
Stomach Cancer 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other measures of subjective intoxication and sedation, and the CPT were unaffected by the alcohol infusions.
Neg (unaffected) Negative_regulation (unaffected) of CPT associated with sleep disorders, poisoning and alcohol
1) Confidence 0.38 Published 1997 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9347092 Disease Relevance 0.28 Pain Relevance 0.60
To test this hypothesis, we only modeled the reaction time (RT) period of each +CPT anticipation block in each subject and directly compared amygdala activation between +CPT and +CPT (RT only) periods.
Negative_regulation (block) of CPT in amygdala associated with amygdala
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993966 Disease Relevance 0.06 Pain Relevance 0.63
Diarrhea is a common side effect of CPT-11 containing regimens.
Negative_regulation (effect) of CPT-11 associated with diarrhoea
3) Confidence 0.36 Published 2004 Journal BMC Cancer Section Body Doc Link PMC476737 Disease Relevance 0.77 Pain Relevance 0
Of the compounds tested above, based on these in vitro data, only the potent inhibitors of carboxylesterase (BNPP, physostigmine) have the potential to inhibit CPT-11 bioactivation if administered concurrently.
Negative_regulation (inhibit) of CPT-11
4) Confidence 0.34 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9321519 Disease Relevance 0 Pain Relevance 0.17
Although the regression of hepatic metastases was seen, we repeated the dose reduction of CPT-11 and the dose down level was reached to 40% for prolonged grade 2 neutropenia.
Negative_regulation (reduction) of CPT-11 associated with neutropenia and metastasis
5) Confidence 0.31 Published 2008 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 19106523 Disease Relevance 0.95 Pain Relevance 0.06
In Table 3, separate linear regressions revealed the unique variance that IBL20, IBL30, IBL40, IBL50, and IBL60 each contributed to the three frequencies of CPT, after adjusting for age, smoking, alcohol use, and ES.
Negative_regulation (frequencies) of CPT associated with nicotine addiction and alcohol
6) Confidence 0.30 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1314913 Disease Relevance 0.23 Pain Relevance 0.05

General Comments

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