INT71676

From wiki-pain
Revision as of 04:31, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.19
Pain Relevance 4.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (DRD2) plasma membrane (DRD2) signal transducer activity (DRD2)
Anatomy Link Frequency
neurons 1
striatum 1
DRD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 158 100.00 Very High Very High Very High
dopamine receptor 48 100.00 Very High Very High Very High
Inflammation 26 99.48 Very High Very High Very High
adenocard 11 99.18 Very High Very High Very High
agonist 17 96.72 Very High Very High Very High
Enkephalin 15 96.28 Very High Very High Very High
substance P 1 95.48 Very High Very High Very High
Nucleus accumbens 20 90.88 High High
withdrawal 7 90.40 High High
antagonist 5 87.88 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 26 99.48 Very High Very High Very High
Opiate Addiction 4 95.04 Very High Very High Very High
Nociception 13 83.00 Quite High
Neuropathic Pain 3 82.52 Quite High
Congenital Anomalies 1 75.00 Quite High
Syndrome 22 63.40 Quite High
Pain 20 59.36 Quite High
Obesity 31 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 15 5.00 Very Low Very Low Very Low
Disease 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D2R mRNA was heterogeneously distributed in the whole striatum with high signals located both in the striosomes and the matrix.
Transcription (distributed) of D2R mRNA in striatum associated with dopamine receptor
1) Confidence 0.69 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332736 Disease Relevance 0 Pain Relevance 1.09
At birth, D2R mRNA became homogeneously distributed while D2R-binding sites kept an heterogeneously distribution.
Transcription (distributed) of D2R mRNA associated with dopamine receptor
2) Confidence 0.69 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332736 Disease Relevance 0 Pain Relevance 0.98
Activation of the DRD2/mRNA results in a negative feedback that promotes an enhancement of mRNA directed D2 receptor proliferation.
Transcription (Activation) of DRD2
3) Confidence 0.67 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.06 Pain Relevance 0.65
Virtually all adenosine A2A receptor mRNA-containing neurons co-expressed dopamine D2 receptor mRNA, whereas only very few adenosine A2A receptor mRNA containing neurons co-expressed dopamine D1 receptor or substance P mRNAs.
Transcription (expressed) of dopamine D2 receptor in neurons associated with dopamine, adenocard and substance p
4) Confidence 0.53 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9721905 Disease Relevance 0 Pain Relevance 0.70
We examined mRNA expression levels of DA transporter (DAT), tyrosine hydroxylase (TH), dopamine D2 receptor, alpha-synuclein, and nuclear receptor-related 1 (Nurr1) in discrete mesocorticolimbic and nigrostriatal subpopulations of heroin users and control subjects.
Spec (examined) Transcription (expression) of dopamine D2 receptor associated with dopamine and opiate addiction
5) Confidence 0.34 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18057194 Disease Relevance 0.25 Pain Relevance 0.41
Also, mRNA levels of D1 and D2R's were measured in the IC after three hours of inflammation.


Transcription (levels) of D2R associated with inflammation
6) Confidence 0.17 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2994804 Disease Relevance 0.89 Pain Relevance 0.64

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox