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Context Info
Confidence 0.54
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 8.21
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCL3) extracellular space (CCL3) extracellular region (CCL3)
intracellular (CCL3) cytoskeleton organization (CCL3) kinase activity (CCL3)
Anatomy Link Frequency
macrophages 4
lung 4
plasma 2
blood 2
microglia 2
CCL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 198 100.00 Very High Very High Very High
Inflammation 116 99.20 Very High Very High Very High
cytokine 88 98.78 Very High Very High Very High
rheumatoid arthritis 107 97.76 Very High Very High Very High
Arthritis 52 97.20 Very High Very High Very High
peptic ulcer disease 1 88.80 High High
Inflammatory stimuli 1 85.20 High High
Inflammatory mediators 12 79.52 Quite High
agonist 1 74.40 Quite High
intrathecal 2 73.04 Quite High
Disease Link Frequency Relevance Heat
Infection 63 99.68 Very High Very High Very High
Disease 81 99.48 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 75 99.48 Very High Very High Very High
INFLAMMATION 136 99.20 Very High Very High Very High
Gastritis 4 99.08 Very High Very High Very High
Rheumatoid Arthritis 107 97.76 Very High Very High Very High
Juvenile Chronic Polyarthritis 40 97.20 Very High Very High Very High
Injury 3 97.08 Very High Very High Very High
Critical Illness 111 95.36 Very High Very High Very High
Arthritis 12 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our investigations have demonstrated that HIV infection of macrophages stimulate considerably the synthesis of MIP-1-alpha, MIP-1-beta RANTES chemokines (subgroup CC).
Positive_regulation (stimulate) of Gene_expression (synthesis) of MIP-1-alpha in macrophages associated with chemokine, acquired immune deficiency syndrome or hiv infection and infection
1) Confidence 0.54 Published 1997 Journal Bratisl Lek Listy Section Abstract Doc Link 9333424 Disease Relevance 2.37 Pain Relevance 0.20
The disease severity correlated with increased plasma levels of IL1RA, IL2, IL6, CCL3, CCL4 and IL10.
Positive_regulation (increased) of Gene_expression (levels) of CCL3 in plasma associated with disease
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948498 Disease Relevance 0.59 Pain Relevance 0.07
Comparison of lung cytokines and chemokines at protein and gene levels showed comparable elevated levels of IL12B, CXCL8, IL1B, CCL3, IL1A and IL6 while IL17, TNF and IL10 were elevated only at the gene level.
Positive_regulation (elevated) of Gene_expression (levels) of CCL3 in lung associated with chemokine and cytokine
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.56 Pain Relevance 0.14
Significantly higher levels of MIP-1alpha and IL-8 were detected in patients with H. pylori infection than in those without infection.
Positive_regulation (levels) of Gene_expression (detected) of MIP-1alpha associated with infection
4) Confidence 0.49 Published 1998 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9872512 Disease Relevance 1.15 Pain Relevance 0.23
Moreover, increased expression of the CCR5 ligand, MIP-1a/CCL3, in humans (as a result of gene duplication) provides protection from HIV acquisition (Gonzalez et al 2005).
Positive_regulation (increased) of Gene_expression (expression) of MIP-1a associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.49 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.55 Pain Relevance 0.20
Comparison of lung cytokines and chemokines at protein and gene levels showed comparable elevated levels of IL12B, CXCL8, IL1B, CCL3, IL1A and IL6 while IL17, TNF and IL10 were elevated only at the gene level.
Positive_regulation (elevated) of Gene_expression (levels) of CCL3 in lung associated with chemokine and cytokine
6) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.56 Pain Relevance 0.14
We demonstrate that the chemokines CCL5 (RANTES) and CCL3 (also known as macrophage inflammatory protein (MIP)-1?)
Positive_regulation (chemokines) of Gene_expression (demonstrate) of CCL3 in macrophage associated with chemokine and inflammation
7) Confidence 0.35 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 1.11 Pain Relevance 0.72
Highly upregulated expression of other chemokine genes was observed for CCL3, CXCL8 and CXCL10, whereas CCL21 was downregulated.
Positive_regulation (upregulated) of Gene_expression (expression) of CCL3 associated with chemokine
8) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212580 Disease Relevance 0.62 Pain Relevance 0.37
Results summarized in Figure 1 show a highly upregulated expression of CCL3 and CCL18 mRNAs, a downregulation of CCL21 mRNA (Figure 1a) and an upregulation of CXCL8 and CXCL10 mRNAs (Figure 1b) in SF PMN from each patient in comparison with blood PMN from healthy donors.
Positive_regulation (upregulated) of Gene_expression (expression) of CCL3 in blood
9) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.22 Pain Relevance 0.11
Potent and sustained expression of the chemokines CCL2, CCL3, CCL4 and CCL5, in addition to that of IL-6 and IL-8, contributes to maintaining the inflammatory environment created by microglia in response to B. burgdorferi
Positive_regulation (contributes) of Gene_expression (expression) of CCL3 in microglia associated with chemokine and inflammation
10) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.49 Pain Relevance 0.21

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