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Context Info
Confidence 0.75
First Reported 1997
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 40
Total Number 54
Disease Relevance 9.01
Pain Relevance 6.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX1) transport (P2RX1) plasma membrane (P2RX1)
protein complex (P2RX1)
Anatomy Link Frequency
TM1 4
colon 2
platelets 2
endothelium 2
sensory neurons 1
P2RX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 7 99.92 Very High Very High Very High
dorsal root ganglion 9 99.84 Very High Very High Very High
adenocard 191 99.74 Very High Very High Very High
antagonist 166 99.22 Very High Very High Very High
Neuropeptide 7 99.16 Very High Very High Very High
agonist 590 98.92 Very High Very High Very High
Glutamate 22 98.40 Very High Very High Very High
allodynia 19 97.60 Very High Very High Very High
qutenza 6 96.96 Very High Very High Very High
cytokine 105 96.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 99.84 Very High Very High Very High
Stress 107 99.54 Very High Very High Very High
Diabetes Mellitus 250 99.08 Very High Very High Very High
Neuropathic Pain 142 97.60 Very High Very High Very High
Apoptosis 19 97.44 Very High Very High Very High
Pain 138 96.16 Very High Very High Very High
Aids-related Complex 2 94.64 High High
Injury 32 93.04 High High
Nociception 22 91.60 High High
Targeted Disruption 96 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P2X receptors, a family of ligand-gated ion channels activated by the endogenous ligand ATP, are highly expressed by DRG neurons.
Gene_expression (expressed) of P2X in DRG associated with dorsal root ganglion
1) Confidence 0.75 Published 1997 Journal Nature Section Abstract Doc Link 9338789 Disease Relevance 0.77 Pain Relevance 0.93
This is consistent with a recent report on the cell surface expression of P2X1 receptors (Vacca et al. 2009).
Gene_expression (expression) of P2X1
2) Confidence 0.74 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0.07 Pain Relevance 0
Overall these studies highlight that trafficking plays an important role in the control of the functional expression of P2X1 receptors and their regulation.



Gene_expression (expression) of P2X1
3) Confidence 0.74 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.11
HEK293 cells stably expressing P2X1-4 receptors were used to determine whether these receptors were localized in lipid rafts.
Gene_expression (expressing) of P2X1
4) Confidence 0.72 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.04
The P2X1 receptor was detected in the same fractions as flotillin as we have shown previously (10).
Gene_expression (detected) of P2X1 receptor
5) Confidence 0.72 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.04
Cell surface expression of the P2X1 receptor was also unaffected by cholesterol disruption (Fig. 3a, lower panel) demonstrating that a change in receptor number does not account for the inhibition of P2X1 receptor responses.
Gene_expression (expression) of P2X1 receptor
6) Confidence 0.72 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.09
Microglia also express another subtype of P2XR, P2X7R, but this receptor subtype appears not to be involved because activation of P2X7Rs typically requires a higher concentration of ATP than used [76, 77] and because TNP-ATP, which does not affect P2X7Rs [78], prevents ATP from stimulating microglia to produce allodynia.
Gene_expression (express) of P2XR in microglia associated with allodynia
7) Confidence 0.65 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 1.14 Pain Relevance 0.92
The limited contribution of newly synthesised P2X1 receptors to FRAP suggests that recovery results predominantly from lateral diffusion of receptors already at the cell surface and/or the insertion of recycling receptors.
Gene_expression (synthesised) of P2X1 in lateral
8) Confidence 0.64 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.03
Does receptor recycling contribute to P2X1 receptors FRAP?
Gene_expression (receptors) of P2X1
9) Confidence 0.64 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.03
The increase in time constant of recovery of P2X1 FRAP following phorbol ester treatment is consistent with a decrease in the time required for recovery from desensitisation (Ase et al. 2005).
Gene_expression (recovery) of P2X1 FRAP
10) Confidence 0.64 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.13
The modest effects of the protein synthesis inhibitor cycloheximide on FRAP suggest that insertion of newly synthesised P2X1 receptors at the cell surface makes only a small contribution to recovery from photo-bleaching.
Gene_expression (synthesised) of P2X1
11) Confidence 0.64 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0.06 Pain Relevance 0
P2X1-eGFP receptor fluorescence recovered with a time constant of ?
Gene_expression (recovered) of P2X1
12) Confidence 0.64 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0
A characteristic feature of P2X1 receptors is that they show rapid receptor desensitisation (time constant ?
Gene_expression (receptors) of P2X1
13) Confidence 0.64 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.05
Swapping the P2X2 receptor TM1 (P2X1-2b), extracellular domain (P2X1-2c), or second half of the carboxyl terminus (P2X1-2e?)
Gene_expression (Swapping) of P2X1-2c in TM1
14) Confidence 0.63 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
To characterize further the contribution of the amino terminus of the P2X1 receptor to cholesterol sensitivity, two additional chimeras were generated, P2X1-2a?
Gene_expression (generated) of P2X1-2a
15) Confidence 0.63 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
for the equivalent P2X1 receptor region reduced the effects of cholesterol depletion by ?
Gene_expression (region) of P2X1 receptor
16) Confidence 0.63 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
Swapping the P2X2 receptor TM1 (P2X1-2b), extracellular domain (P2X1-2c), or second half of the carboxyl terminus (P2X1-2e?)
Gene_expression (Swapping) of P2X1 in TM1
17) Confidence 0.63 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
Alternatively, the cells expressing P2X1-4 subtype receptors were lysed in 2 ml of MBS (25 mm MES and 150 mm NaCl, pH 6.5) containing Triton X-100 (0.1, 0.3, or 1%).
Gene_expression (expressing) of P2X1
18) Confidence 0.63 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
Swapping the P2X2 receptor TM1 (P2X1-2b), extracellular domain (P2X1-2c), or second half of the carboxyl terminus (P2X1-2e?)
Gene_expression (Swapping) of P2X2 receptor TM1 in TM1
19) Confidence 0.63 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
HEK293 cells stably expressing the P2X1 receptor were treated with 1 ?
Gene_expression (expressing) of P2X1 receptor
20) Confidence 0.60 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0.03

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