INT71876

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Context Info
Confidence 0.43
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.03
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tbp) DNA binding (Tbp) transcription factor binding (Tbp)
cytoplasm (Tbp)
Tbp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 63 99.48 Very High Very High Very High
Hippocampus 10 96.04 Very High Very High Very High
Action potential 5 89.04 High High
Inflammation 5 80.32 Quite High
Potency 1 80.20 Quite High
cINOD 2 73.92 Quite High
depression 3 66.88 Quite High
Pyramidal cell 15 47.52 Quite Low
agonist 22 32.64 Quite Low
antagonist 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 22 93.32 High High
Neurodegenerative Disease 10 82.64 Quite High
INFLAMMATION 6 80.32 Quite High
Disease 13 77.44 Quite High
Apoptosis 30 68.12 Quite High
Depression 3 66.88 Quite High
Cognitive Disorder 7 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Dementia 2 5.00 Very Low Very Low Very Low
Tremor 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TATA less promoters depend on TBP participation in the pre-initiation complex by localizing it to the promoter through other DNA binding proteins.
Regulation (depend) of TBP
1) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.48 Pain Relevance 0
Therefore we studied the effect of polyQ length on TBP occupancy at promoters of differentially expressed genes by chromatin immunoprecipitation(ChIP) using TBP specific N12 antibody.
Regulation (effect) of TBP
2) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0 Pain Relevance 0
We next investigated the role of selective M1 receptor activation on LTP induced by a theta burst pairing (TBP) protocol.
Regulation (pairing) of TBP associated with long-term potentiation
3) Confidence 0.21 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0.18 Pain Relevance 0.44
This inhibition is selective, as the activity of four other transcription factors, Oct-1, TBP, Sp1 and STAT 5 was not affected.
Neg (not) Regulation (affected) of TBP
4) Confidence 0.05 Published 1997 Journal Biol. Chem. Section Abstract Doc Link 9348104 Disease Relevance 0.36 Pain Relevance 0.37

General Comments

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