INT71876

Context Info Confidence 0.43 First Reported 1997 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.03 Pain Relevance 0.80

nucleus (Tbp) DNA binding (Tbp) transcription factor binding (Tbp) cytoplasm (Tbp)

Tbp (Mus musculus)

Pain Link Frequency Relevance Heat long-term potentiation 63 99.48 Hippocampus 10 96.04 Action potential 5 89.04 Inflammation 5 80.32 Potency 1 80.20 cINOD 2 73.92 depression 3 66.88 Pyramidal cell 15 47.52 agonist 22 32.64 antagonist 7 5.00

Disease Link Frequency Relevance Heat Death 22 93.32 Neurodegenerative Disease 10 82.64 INFLAMMATION 6 80.32 Disease 13 77.44 Apoptosis 30 68.12 Depression 3 66.88 Cognitive Disorder 7 5.00 Targeted Disruption 3 5.00 Dementia 2 5.00 Tremor 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TATA less promoters depend on TBP participation in the pre-initiation complex by localizing it to the promoter through other DNA binding proteins.

Regulation (depend) of TBP

1) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.48 Pain Relevance 0

Therefore we studied the effect of polyQ length on TBP occupancy at promoters of differentially expressed genes by chromatin immunoprecipitation(ChIP) using TBP specific N12 antibody.

Regulation (effect) of TBP

2) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0 Pain Relevance 0

We next investigated the role of selective M1 receptor activation on LTP induced by a theta burst pairing (TBP) protocol.

Regulation (pairing) of TBP associated with long-term potentiation

3) Confidence 0.21 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0.18 Pain Relevance 0.44

This inhibition is selective, as the activity of four other transcription factors, Oct-1, TBP, Sp1 and STAT 5 was not affected.

Neg (not) Regulation (affected) of TBP

4) Confidence 0.05 Published 1997 Journal Biol. Chem. Section Abstract Doc Link 9348104 Disease Relevance 0.36 Pain Relevance 0.37

General Comments

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