INT71906

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 22
Total Number 26
Disease Relevance 11.01
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
MCF-7 4
testis 3
blood 2
lymph node 2
uterus 2
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 2 99.88 Very High Very High Very High
Potency 11 98.00 Very High Very High Very High
addiction 6 97.52 Very High Very High Very High
opiate 1 94.32 High High
Dopamine 2 93.36 High High
cocaine 292 91.36 High High
anesthesia 5 79.96 Quite High
Snapping jaw 1 74.52 Quite High
Central nervous system 10 72.00 Quite High
Cannabinoid receptor 1 62.64 Quite High
Disease Link Frequency Relevance Heat
Disease 92 100.00 Very High Very High Very High
Ductal Carcinoma 4 99.90 Very High Very High Very High
Breast Cancer 476 99.76 Very High Very High Very High
Cancer 331 99.68 Very High Very High Very High
Aging 11 99.68 Very High Very High Very High
Adenocarcinoma 21 99.56 Very High Very High Very High
Metastasis 43 98.80 Very High Very High Very High
Noninfiltrating Intraductal Carcinoma 9 98.80 Very High Very High Very High
Reprotox - General 1 34 98.04 Very High Very High Very High
Hyperplasia 3 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, as shown by the current observations using MCF-7 cells, ibandronate had no direct effect on ER expression and did not affect E2-induced receptor down-regulation.
Regulation (effect) of Gene_expression (expression) of ER in MCF-7
1) Confidence 0.41 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413981 Disease Relevance 0.24 Pain Relevance 0
The expression of ER and PR in these cell lines has been re-examined to determine their presence in lymph node metastases from patients who did not receive any kind of endocrine therapy and in distant metastases obtained from patients who failed endocrine treatment.
Spec (determine) Regulation (determine) of Gene_expression (expression) of ER in lymph node associated with metastasis
2) Confidence 0.38 Published 1997 Journal J. Pathol. Section Abstract Doc Link 9349240 Disease Relevance 0.42 Pain Relevance 0
The potent estrogenic effluent, but not the weakly estrogenic effluent, up-regulated the expression of esr1 in liver and testis (Figure 1E,F).
Regulation (regulated) of Gene_expression (expression) of esr1 in testis
3) Confidence 0.35 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0 Pain Relevance 0
In conclusion, vaginal tissue of tumor and control bitches, under different distinct steroid influences, had different ER-alpha expression, whereas ER-alpha expression was not present in neoplastic tissues.
Regulation (had) of Gene_expression (expression) of ER-alpha associated with cancer
4) Confidence 0.30 Published 2006 Journal Theriogenology Section Abstract Doc Link 16483645 Disease Relevance 0.63 Pain Relevance 0.08
in human MCF-7 cells and correlated with ER status in breast adenocarcinomas
Regulation (correlated) of Gene_expression (status) of ER in MCF-7 associated with adenocarcinoma
5) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.17 Pain Relevance 0.05
regulation of TRPM8 in a physiological context, we studied the correlation between the over-expression of TRPM8 and ER?
Regulation (correlation) of Gene_expression (over) of ER
6) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.57 Pain Relevance 0.03
is able to regulate endogenous genes in a ligand-dependent manner, ectopically expressed ER?
Regulation (regulate) of Gene_expression (expressed) of ER
7) Confidence 0.25 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.54 Pain Relevance 0
Because the ER and the androgen receptor belong to the steroid receptor superfamily, we examined whether these compounds affected ER expression and signaling in breast cancer cells.


Spec (whether) Regulation (affected) of Gene_expression (expression) of ER associated with breast cancer
8) Confidence 0.25 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC2246173 Disease Relevance 0.58 Pain Relevance 0
No difference in ER protein expression (as defined by IHC) was observed between the two groups (p = 0.25) (Additionnal file 1-Table S7B).
Neg (No) Regulation (difference) of Gene_expression (expression) of ER
9) Confidence 0.25 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.54 Pain Relevance 0
There are three general goals for better therapies in breast cancer, improving therapies for ER+ disease, finding therapies for ER?
Regulation (therapies) of Gene_expression (disease) of ER associated with breast cancer and disease
10) Confidence 0.25 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 1.18 Pain Relevance 0
for invasive ductal carcinoma and lacks estrogen receptor (ER) expression.
Regulation (lacks) of Neg (lacks) Gene_expression (expression) of ER associated with ductal carcinoma
11) Confidence 0.24 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 1.64 Pain Relevance 0
for invasive ductal carcinoma and lacks estrogen receptor (ER) expression.
Regulation (lacks) of Neg (lacks) Gene_expression (expression) of estrogen receptor associated with ductal carcinoma
12) Confidence 0.24 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 1.64 Pain Relevance 0
The classical mechanism of ER signaling involves binding of
Regulation (involves) of Gene_expression (mechanism) of ER
13) Confidence 0.24 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.63 Pain Relevance 0
Morphine down regulates human vascular tissue estrogen receptor expression determined by real-time RT-PCR.
Regulation (regulates) of Gene_expression (expression) of estrogen receptor associated with morphine
14) Confidence 0.22 Published 2002 Journal Neuro Endocrinol. Lett. Section Title Doc Link 12011792 Disease Relevance 0 Pain Relevance 0.29
Where feasible, serial biopsies will be obtained to assess for treatment induced changes in acetylation and ER expression.


Regulation (changes) of Gene_expression (expression) of ER
15) Confidence 0.21 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.55 Pain Relevance 0
In the case of ER, the reason is that the protein stability but not the mRNA expression determines the levels of the ER in the tumour cells and thus the ER status of the tumors [130].
Spec (determines) Regulation (determines) of Gene_expression (levels) of ER associated with cancer
16) Confidence 0.18 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.33 Pain Relevance 0
The greater endocrine-disrupting ability (effects on VTG, secondary sex characters, and esr1 expression) of the WwTW effluent with the higher estrogenic potency compared with that of the more weakly estrogenic effluent, together with the enhanced endocrine-disrupting ability of the weakly estrogenic effluent after addition of EE2, were as expected and consistent with the fact that steroidal estrogens play a key role in disrupting sexual development in exposed fish.
Regulation (effects) of Gene_expression (expression) of esr1 associated with potency
17) Confidence 0.15 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0 Pain Relevance 0.07
The potent estrogenic effluent, but not the weakly estrogenic effluent, up-regulated the expression of esr1 in liver and testis (Figure 1E,F).
Regulation (regulated) of in liver Gene_expression (expression) of esr1 in testis
18) Confidence 0.12 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0 Pain Relevance 0
Two principal sources of Ca2+ affect the concentration of cytosolic Ca2+: internal Ca2+ stores, primarily in the endoplasmic reticulum (ER), and extracellular Ca2+.
Regulation (affect) of Gene_expression (stores) of ER in reticulum
19) Confidence 0.09 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.03
Normal feline uterus was used as a positive control for ER and PR detection.
Regulation (control) of Gene_expression (detection) of ER in uterus
20) Confidence 0.09 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468625 Disease Relevance 0.17 Pain Relevance 0

General Comments

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