INT71974

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 13.93
Pain Relevance 4.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SLC9A1) plasma membrane (SLC9A1) transcription factor binding (SLC9A1)
transmembrane transport (SLC9A1)
Anatomy Link Frequency
vein 2
endothelial cells 1
platelets 1
epithelial cells 1
placentas 1
SLC9A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 10 100.00 Very High Very High Very High
Clonidine 9 99.48 Very High Very High Very High
antagonist 2 99.40 Very High Very High Very High
Inflammatory response 32 99.28 Very High Very High Very High
ischemia 229 98.86 Very High Very High Very High
Inflammation 29 98.04 Very High Very High Very High
tetrodotoxin 2 96.88 Very High Very High Very High
Glutamate 10 92.44 High High
agonist 1 88.36 High High
cva 88 83.60 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 368 99.28 Very High Very High Very High
Death 97 99.16 Very High Very High Very High
INFLAMMATION 54 98.92 Very High Very High Very High
Inflammatory Bowel Disease 20 98.92 Very High Very High Very High
Cv Unclassified Under Development 216 98.86 Very High Very High Very High
Coronary Heart Disease 16 98.20 Very High Very High Very High
Necrosis 120 97.68 Very High Very High Very High
Disease 37 97.36 Very High Very High Very High
Contracture 16 96.20 Very High Very High Very High
Mucositis 4 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockade of NHE1 by the potent antagonist, 5-(N-ethyl-N-isopropyl) amiloride (1 microM), abolished the protective effects of small concentrations of propofol (1 microM) and alpha-tocopherol (40 microM) on glutamate uptake during oxidative stress in bicarbonate-free medium. 5-(N-ethyl-N-isopropyl) amiloride had no effect on antioxidant rescue of glutamate transport in medium containing 25 mM bicarbonate.
Negative_regulation (Blockade) of NHE1 associated with stress, glutamate and antagonist
1) Confidence 0.41 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11682397 Disease Relevance 0.24 Pain Relevance 0.36
Cariporide (HOE642A) was developed recently as a selective inhibitor of the NHE exchanger [8].
Negative_regulation (inhibitor) of NHE
2) Confidence 0.36 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.64 Pain Relevance 0.10
Internal data has shown a dose-dependent inhibition of the NHE system in platelets, with 100% inhibition reached within 15 min after the injection of a bolus dose of 60 mg, declining to approximately 50% after 4 h.
Negative_regulation (inhibition) of NHE in platelets
3) Confidence 0.36 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.65 Pain Relevance 0.13
The GUARDIAN trial was the first large-scale trial designed to assess the potential protective effect of NHE inhibition in humans.
Negative_regulation (inhibition) of NHE
4) Confidence 0.30 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.42 Pain Relevance 0.12
Cardioprotective effects of cariporide have consistently been documented in various experimental models of ischemia/reperfusion, with marked reduction in infarct size when NHE inhibitors were administered before or early during ischemia [9].
Negative_regulation (inhibitors) of NHE associated with ischemia
5) Confidence 0.26 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.63 Pain Relevance 0.13
It originally tested a novel pharmacologic agent (cariporide) and the hypothesis that inhibition of the NHE that is believed to play a fundamental in producing cell necrosis during ischemia (NHE) would prevent MI.
Negative_regulation (inhibition) of NHE associated with necrosis, ischemia and myocardial infarction
6) Confidence 0.26 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.57 Pain Relevance 0.18
A strong incentive to the choice of the primary end-point of prevention of death or MI was the experimental findings that NHE inhibition yielded maximal benefit when applied before coronary occlusion or early during ischemia rather than before reperfusion [8,10,11].
Negative_regulation (inhibition) of NHE associated with ischemia, coronary heart disease, myocardial infarction and death
7) Confidence 0.26 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 1.61 Pain Relevance 0.22
The GUARDIAN trial was designed to investigate one of these promising interventions, the inhibition of the NHE by cariporide.
Spec (investigate) Negative_regulation (inhibition) of NHE
8) Confidence 0.26 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 1.05 Pain Relevance 0.03
The present paper describes a trial that was intended to investigate the potential clinical benefit of cariporide, a potent and selective inhibitor of the NHE, in a large spectrum of at-risk patients.


Negative_regulation (inhibitor) of NHE
9) Confidence 0.26 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Abstract Doc Link PMC56207 Disease Relevance 1.16 Pain Relevance 0.24
NHE inhibition decreased also the IL-1beta-induced HUVEC inflammatory response, because amiloride suppressed IL-1beta-induced E-selectin expression on HUVECs.
Negative_regulation (inhibition) of NHE associated with inflammatory response
10) Confidence 0.21 Published 2002 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12107048 Disease Relevance 0.45 Pain Relevance 0.35
NHE inhibitors suppressed both inhibitory (I)kappaB degradation and nuclear factor (NF)-kappaB DNA binding, suggesting that a decrease in activation of the IkappaB-NF-kappaB system contributed to the suppression of HUVEC inflammatory response by NHE blockade.
Negative_regulation (inhibitors) of NHE associated with inflammatory response
11) Confidence 0.21 Published 2002 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12107048 Disease Relevance 0.46 Pain Relevance 0.35
NHE blockade inhibits chemokine production and NF-kappaB activation in immunostimulated endothelial cells.
Negative_regulation (blockade) of NHE in endothelial cells associated with chemokine
12) Confidence 0.21 Published 2002 Journal Am. J. Physiol., Cell Physiol. Section Title Doc Link 12107048 Disease Relevance 0.41 Pain Relevance 0.33
NHE inhibition using amiloride, 5-(N-ethyl-N-isopropyl)-amiloride, and 5-(N-methyl-N-isobutyl)amiloride as well as the non-amiloride NHE inhibitors cimetidine, clonidine, and harmaline suppressed endotoxin-induced IL-8 and monocyte chemoattractant protein (MCP)-1 production by human umbilical endothelial vein cells (HUVECs).
Negative_regulation (inhibitors) of NHE in vein associated with clonidine
13) Confidence 0.18 Published 2002 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12107048 Disease Relevance 0.40 Pain Relevance 0.30
NHE inhibition using amiloride, 5-(N-ethyl-N-isopropyl)-amiloride, and 5-(N-methyl-N-isobutyl)amiloride as well as the non-amiloride NHE inhibitors cimetidine, clonidine, and harmaline suppressed endotoxin-induced IL-8 and monocyte chemoattractant protein (MCP)-1 production by human umbilical endothelial vein cells (HUVECs).
Negative_regulation (inhibition) of NHE in vein associated with clonidine
14) Confidence 0.18 Published 2002 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12107048 Disease Relevance 0.37 Pain Relevance 0.27
Thus, activation of H3R appears to result in an inhibition of both NHE- and voltage-dependent Na+ channels.
Negative_regulation (inhibition) of NHE
15) Confidence 0.18 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353362 Disease Relevance 0.30 Pain Relevance 0.45
However, Khan et al published conflicting results describing a reduction of COX-2 and of the amount of NHE-1 in pre-eclamptic placentas with an unaltered level of COX-1 [19].
Negative_regulation (reduction) of NHE-1 in placentas
16) Confidence 0.03 Published 2010 Journal Malar J Section Body Doc Link PMC2831904 Disease Relevance 1.00 Pain Relevance 0.06
NHE inhibition suppressed both activation of the p42/p44 mitogen-activated protein kinase and nuclear factor-kappaB.
Negative_regulation (inhibition) of NHE
17) Confidence 0.02 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12065299 Disease Relevance 0.88 Pain Relevance 0.32
Finally, NHE inhibition ameliorated the course of IBD in dextran sulfate-treated mice.
Negative_regulation (inhibition) of NHE associated with inflammatory bowel disease
18) Confidence 0.02 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12065299 Disease Relevance 0.85 Pain Relevance 0.31
The inhibitory effect of NHE inhibition on IL-8 was associated with a decrease in IL-8 mRNA accumulation.
Negative_regulation (inhibition) of NHE
19) Confidence 0.02 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12065299 Disease Relevance 0.90 Pain Relevance 0.34
In human gut epithelial cells, NHE inhibition using a variety of agents, including amiloride, 5-(N-methyl-N-isobutyl)amiloride, 5-(N-ethyl-N-isopropyl)- amiloride, harmaline, clonidine, and cimetidine, suppressed interleukin-8 (IL-8) production.
Negative_regulation (inhibition) of NHE in epithelial cells associated with clonidine
20) Confidence 0.02 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12065299 Disease Relevance 0.95 Pain Relevance 0.36

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