INT72060

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 2011
Negated 7
Speculated 3
Reported most in Body
Documents 127
Total Number 130
Disease Relevance 76.76
Pain Relevance 20.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) plasma membrane (Ros1)
Anatomy Link Frequency
hepatocytes 10
plasma 6
NR8383 6
Caco-2 6
neuronal 6
Ros1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 692 100.00 Very High Very High Very High
Paracetamol 686 100.00 Very High Very High Very High
Spinal cord 50 100.00 Very High Very High Very High
Inflammatory mediators 22 100.00 Very High Very High Very High
qutenza 15 100.00 Very High Very High Very High
cerebral cortex 16 99.84 Very High Very High Very High
ischemia 401 99.74 Very High Very High Very High
cva 45 99.72 Very High Very High Very High
Sciatic nerve 2 99.52 Very High Very High Very High
Prostatitis 66 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1581 100.00 Very High Very High Very High
INFLAMMATION 757 100.00 Very High Very High Very High
Hyperglycemia 139 99.98 Very High Very High Very High
Hyperoxia 26 99.98 Very High Very High Very High
Injury 401 99.92 Very High Very High Very High
Diabetes Mellitus 1515 99.84 Very High Very High Very High
Reprotox - General 1 77 99.84 Very High Very High Very High
Toxicity 231 99.78 Very High Very High Very High
Inflammatory Bowel Disease 32 99.78 Very High Very High Very High
Cv Unclassified Under Development 269 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, these events are dependent on increased ROS generation and, possibly, a subsequent decrease in tissue NO levels during systemic hypoxia.
Spec (possibly) Positive_regulation (increased) of Gene_expression (generation) of ROS associated with hypoxia
1) Confidence 0.41 Published 2000 Journal J. Appl. Physiol. Section Abstract Doc Link 11007596 Disease Relevance 0.71 Pain Relevance 0.09
Apart from the pro-oxidative effect of environmental factors such as diet and inflammation, we [7], [37] and others [38] have shown that androgens increase the production of ROS in PC cells.
Positive_regulation (increase) of Gene_expression (production) of ROS associated with inflammation and reprotox - general 1
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011012 Disease Relevance 1.63 Pain Relevance 0.05
Since oxidation of DA and xanthines generates reactive oxygen species (ROS) and AA and UA are the main cellular antioxidants, these findings suggest that: (a) single morphine administration increases DA and xanthine oxidative metabolism with a consequent increase in ROS production, which may account for changes in concentrations of extracellular AA and tissue DHAA; (b) allopurinol decreases morphine-induced DA and xanthine oxidation; (c) UA and AA may act in concert to regulate levels of ROS in the brain.
Positive_regulation (increase) of Gene_expression (production) of ROS in brain associated with dopamine and morphine
3) Confidence 0.38 Published 1997 Journal Pharmacol. Res. Section Abstract Doc Link 9356212 Disease Relevance 0 Pain Relevance 0.89
ROS production was significantly increased and was highest in samples from the inferior vena cava.
Positive_regulation (increased) of Gene_expression (production) of ROS in inferior vena cava
4) Confidence 0.37 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18806041 Disease Relevance 0 Pain Relevance 0
In contrast, RLM isolated from responders showed a marked increase in ROS production compared with both the control group and nonresponders.
Positive_regulation (increase) of Gene_expression (production) of ROS
5) Confidence 0.36 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16474010 Disease Relevance 0.22 Pain Relevance 0.09
Increased levels of ROS within the prostate stimulate cell proliferation, induce somatic DNA mutations and promote genetic instability facilitating the development and progression of PC [2].
Positive_regulation (Increased) of Gene_expression (levels) of ROS associated with reprotox - general 1
6) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011012 Disease Relevance 1.58 Pain Relevance 0.04
More specifically, increased levels of ROS can cause oxidative DNA damage.
Positive_regulation (increased) of Gene_expression (levels) of ROS
7) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011012 Disease Relevance 1.00 Pain Relevance 0.07
The ROS threshold for MPT induction (tMPT) was measured as the average time necessary to induce MPT in a row consisting of ?
Positive_regulation (induction) of Gene_expression (threshold) of ROS in row
8) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2693933 Disease Relevance 0.05 Pain Relevance 0.08
This procedure results in incremental, additive exposure of only the laser-exposed area to the photodynamic production of ROS and consequent MPT induction.
Positive_regulation (exposed) of Gene_expression (production) of ROS
9) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2693933 Disease Relevance 0.09 Pain Relevance 0
Antioxidants significantly inhibited ROS generation.
Positive_regulation (generation) of Gene_expression (generation) of ROS
10) Confidence 0.24 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17761838 Disease Relevance 0.35 Pain Relevance 0.21
Increased ROS production was found already after 3 h of incubation in 2.5, 5, 10 and 20 mM AAP, respectively.
Positive_regulation (Increased) of Gene_expression (production) of ROS associated with paracetamol
11) Confidence 0.24 Published 2009 Journal Physiol Res Section Abstract Doc Link 18380536 Disease Relevance 0.07 Pain Relevance 0.87
Indomethacin-induced ROS production was evaluated by detecting the oxidation of a redox-sensitive fluorogenic probe, RedoxSensor, and the oxidation of cysteine residues of proteins (protein S oxidation).
Positive_regulation (-) of Gene_expression (production) of ROS
12) Confidence 0.22 Published 2010 Journal J. Gastroenterol. Section Body Doc Link 20174833 Disease Relevance 0.09 Pain Relevance 0
Indomethacin also induced ROS production and an increase in the protein S oxidation of RIE-1.
Positive_regulation (induced) of Gene_expression (production) of ROS
13) Confidence 0.22 Published 2010 Journal J. Gastroenterol. Section Body Doc Link 20174833 Disease Relevance 0.07 Pain Relevance 0
Hyperglycemia as well as elevated plasma free fatty acids and triglycerides also contribute to increased ROS production in addition to initiating insulin resistance through down-regulation of insulin signaling pathway intermediates [9-11]
Positive_regulation (contribute) of Gene_expression (production) of ROS in plasma associated with hyperglycemia and insulin resistance
14) Confidence 0.21 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 0.80 Pain Relevance 0.09
Hyperglycemia as well as elevated plasma free fatty acids and triglycerides also contribute to increased ROS production in addition to initiating insulin resistance through down-regulation of insulin signaling pathway intermediates [9-11]
Positive_regulation (increased) of Gene_expression (production) of ROS in plasma associated with hyperglycemia and insulin resistance
15) Confidence 0.21 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 0.80 Pain Relevance 0.09
Based on the observed association between reduced ROS and increased susceptibility to arthritis, the researchers wanted to find out whether treatment with a compound that increases ROS production by the NADPH oxidase complex would cause an improvement in arthritis.


Positive_regulation (increases) of Gene_expression (production) of ROS associated with arthritis
16) Confidence 0.20 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1564167 Disease Relevance 1.41 Pain Relevance 0.63
T cells were also stimulated with plate-bound anti-CD3, but this did not further increase the ROS production (Figure S1).
Neg (not) Positive_regulation (increase) of Gene_expression (production) of ROS in T cells
17) Confidence 0.20 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564167 Disease Relevance 0.12 Pain Relevance 0.06
Treatment with oxidative burst inducers was thus far done by increasing ROS production in DA.Ncf1DA rats.
Positive_regulation (increasing) of Gene_expression (production) of ROS
18) Confidence 0.20 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564167 Disease Relevance 1.21 Pain Relevance 0.44
Also after PMA stimulation, phytol-primed granulocytes had a higher response capacity (Figure 3A), whereas T cells showed only a barely detectable increase in ROS production (Figure 3B).
Positive_regulation (increase) of Gene_expression (production) of ROS in granulocytes
19) Confidence 0.20 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564167 Disease Relevance 0.22 Pain Relevance 0.11
CS(2) exposure was found to markedly increase ROS and MDA levels in cerebral cortex, hippocampus, spinal cord and serum of rats in both time and symptom-dependent manners.
Positive_regulation (increase) of Gene_expression (levels) of ROS in spinal cord associated with hippocampus, cerebral cortex and spinal cord
20) Confidence 0.19 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19070609 Disease Relevance 0.21 Pain Relevance 0.41

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