INT72215

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Context Info
Confidence 0.08
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.25
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (METTL3) methyltransferase activity (METTL3) RNA binding (METTL3)
nucleus (METTL3)
METTL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 5 100.00 Very High Very High Very High
Kinase C 52 99.52 Very High Very High Very High
Neuropathic pain 1 95.16 Very High Very High Very High
Opioid 1 93.20 High High
nMDA receptor 1 91.24 High High
Morphine 1 87.68 High High
Endogenous opioid 1 85.32 High High
Analgesic 1 84.16 Quite High
agonist 4 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 1 95.16 Very High Very High Very High
Cancer 16 79.76 Quite High
Neuroblastoma 2 75.00 Quite High
Repression 4 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Reprotox - General 1 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low
Cervical Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One possibility is that PKC activation regulates MuOR mRNA expression and thus the ability to generate functional receptors.
Regulation (regulates) of Gene_expression (expression) of MuOR mRNA associated with kinase c and mu opioid receptor
1) Confidence 0.08 Published 1997 Journal Anesthesiology Section Abstract Doc Link 9366465 Disease Relevance 0.17 Pain Relevance 0.92
Receptor Ck-dependent signaling was also found to down-regulate the mRNA expression of the gene coding for the ligand inducible transcription factor, peroxisome proliferator-activated receptor ?
Regulation (regulate) of Gene_expression (expression) of mRNA
2) Confidence 0.00 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.08 Pain Relevance 0.11

General Comments

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