INT72249

Context Info Confidence 0.36 First Reported 1997 Last Reported 2008 Negated 0 Speculated 1 Reported most in Abstract Documents 6 Total Number 7 Disease Relevance 1.08 Pain Relevance 1.41

extracellular space (ABP1) oxidoreductase activity (ABP1) extracellular region (ABP1) plasma membrane (ABP1) peroxisome (ABP1)

Anatomy Link Frequency Lens 2 kidney 2 ABP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Clonidine 15 99.12 anesthesia 5 82.04 Inflammation 3 5.00 Pain 2 5.00 aspirin 1 5.00 ketamine 1 5.00 Perioperative pain 1 5.00 cINOD 1 5.00 Buprenorphine 1 5.00 analgesia 1 5.00

Disease Link Frequency Relevance Heat Disease 40 99.84 Cognitive Disorder 40 98.48 Pneumoperitoneum 22 95.92 Stress 10 93.60 Aging 2 77.04 Pressure Volume 2 Under Development 1 75.96 Dementia 3 61.56 Acidosis 7 54.88 Mental Disorders 1 33.84 INFLAMMATION 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Competitive inhibition of swine kidney copper amine oxidase by diuretic, antihypertensive, and anticoagulant drugs, amiloride, clonidine, and gabexate mesylate, respectively, is reported.

Negative_regulation (inhibition) of amine oxidase in kidney associated with clonidine

1) Confidence 0.36 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9367901 Disease Relevance 0 Pain Relevance 0.24

Competitive inhibition of swine kidney copper amine oxidase by drugs: amiloride, clonidine, and gabexate mesylate.

Negative_regulation (inhibition) of amine oxidase in kidney associated with clonidine

2) Confidence 0.36 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 9367901 Disease Relevance 0 Pain Relevance 0.27

We found that serum AOC is reduced in AD patients and is associated with their cognitive scores.

Negative_regulation (reduced) of serum AOC associated with cognitive disorder and disease

3) Confidence 0.33 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1420275 Disease Relevance 0.85 Pain Relevance 0

Competitive inhibition of Lens culinaris L. copper amine oxidase by amiloride, p-aminobenzamidine, clonidine, 4',6-diamidino-2-phenylindole and gabexate mesylate: a comparative study.

Negative_regulation (inhibition) of amine oxidase in Lens associated with clonidine

4) Confidence 0.33 Published 1998 Journal J. Enzym. Inhib. Section Title Doc Link 9825309 Disease Relevance 0 Pain Relevance 0.27

The competitive inhibition of Lens culinaris L. copper amine oxidase by amiloride (Ki = 4.1 x 10(-4) M), p-aminobenzamidine (Ki = 6.0 x 10(-4) M), clonidine (Ki = 5.0 x 10(-4) M), 4',6-diamidino-2-phenylindole (DAPI; Ki = 1.9 x 10(-5) M) and gabexate mesylate (Ki = 2.5 x 10(-4) M) has been investigated, at pH 7.0 and 25 degrees C.

Spec (investigated) Negative_regulation (inhibition) of amine oxidase in Lens associated with clonidine

5) Confidence 0.33 Published 1998 Journal J. Enzym. Inhib. Section Abstract Doc Link 9825309 Disease Relevance 0 Pain Relevance 0.25

Thus, amiloride and gabexate mesylate may represent useful model compounds for the development of selective inhibitors of mammalian copper amine oxidase, which may be important in view of the potential use of plant copper amine oxidase as drugs.

Negative_regulation (inhibitors) of amine oxidase

6) Confidence 0.25 Published 1998 Journal J. Enzym. Inhib. Section Abstract Doc Link 9825309 Disease Relevance 0 Pain Relevance 0.24

After declamping (T5), a significant increase in CO and SV and a significant decrease in ABP and

Negative_regulation (decrease) of ABP

7) Confidence 0.05 Published 2008 Journal Anesthesiology Research and Practice Section Body Doc Link PMC3003954 Disease Relevance 0.23 Pain Relevance 0.14

General Comments

This test has worked.