INT72251

Context Info Confidence 0.05 First Reported 1997 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.07 Pain Relevance 0.13

endoplasmic reticulum (Kcnma1) plasma membrane (Kcnma1)

Anatomy Link Frequency myocytes 1 brain 1 Kcnma1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat ASIC 2 93.52 dorsal root ganglion 2 75.00 tetrodotoxin 1 50.00 Pain 1 28.80

Disease Link Frequency Relevance Heat Ganglion Cysts 2 75.00 Myocardial Infarction 2 50.00 Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CONCLUSIONS: Our data suggest that I(Ca(TTX))-like current in PMI myocytes does not arise from classical Na(+) channels modified by oxidative stress or PKA phosphorylation and most probably represents a different Na(+) channel type re-expressed in some cells after remodelling.

Phosphorylation (phosphorylation) of channel in myocytes

1) Confidence 0.05 Published 2004 Journal Cardiovasc. Res. Section Body Doc Link 15306221 Disease Relevance 0 Pain Relevance 0

In addition, we have cloned from mouse and rat brain a splice variant form of the MDEG1 channel which differs in the first 236 amino acids, including the first transmembrane region.

Phosphorylation (form) of channel in brain

2) Confidence 0.01 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9368048 Disease Relevance 0.07 Pain Relevance 0.13

General Comments

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