INT72311

Context Info Confidence 0.00 First Reported 1996 Last Reported 1996 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.33 Pain Relevance 0.13

extracellular space (Vcam1) aging (Vcam1) cell adhesion (Vcam1)

Anatomy Link Frequency reticulocytes 1 reticulocyte alpha 4 beta 1 (Mus musculus) Vcam1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 1 98.16 Pain 1 77.04

Disease Link Frequency Relevance Heat Adhesions 1 100.00 Pain 1 77.04 Sickle Cell Anemia 3 76.24

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Four receptor-mediated adherence pathways have been described to date: adherence mediated by high molecular weight von Willebrand factor multimers bridging glycoprotein lb-like and integrin receptors on sickle cells and similar receptors on endothelial cells; thrombospondin bridging CD36 on sickle reticulocytes and the alpha v beta 3 integrin on large-vessel endothelial cells or alpha v beta 3 and CD36 on microvascular endothelium; binding of sickle reticulocyte alpha 4 beta 1 receptors to vascular cell adhesion molecule 1 expressed on endothelial cells stimulated by cytokine or double-stranded RNA viruses; and binding of sickle cells to endothelial cell-associated fibronectin via sickle reticulocyte alpha 4 beta 1 activated by phorbol ester or interleukin-8.

reticulocyte alpha 4 beta 1 Binding (binding) of vascular cell adhesion molecule 1 in reticulocytes associated with adhesions and cytokine

1) Confidence 0.00 Published 1996 Journal Curr. Opin. Hematol. Section Abstract Doc Link 9372061 Disease Relevance 0.33 Pain Relevance 0.13

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