INT72458

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 5.59
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Tnnt2) protein binding, bridging (Tnnt2) cytoplasm (Tnnt2)
Anatomy Link Frequency
chest 2
sensory neurons 1
Tnnt2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
allodynia 1 99.96 Very High Very High Very High
Hyperalgesia 1 99.68 Very High Very High Very High
Pain 3 99.36 Very High Very High Very High
depression 5 99.16 Very High Very High Very High
Angina 8 97.96 Very High Very High Very High
diabetic neuropathy 2 95.72 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 8 93.36 High High
qutenza 1 92.92 High High
ischemia 7 83.20 Quite High
Painful diabetic neuropathy 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 1 99.96 Very High Very High Very High
Peripheral Arterial Disease 11 99.84 Very High Very High Very High
Hyperalgesia 1 99.68 Very High Very High Very High
Pain 3 99.36 Very High Very High Very High
Myocardial Infarction 17 99.16 Very High Very High Very High
Depression 5 99.16 Very High Very High Very High
Angina 7 97.96 Very High Very High Very High
Diabetes Mellitus 88 97.72 Very High Very High Very High
Hyperlipidemia 1 97.12 Very High Very High Very High
Hypertension 1 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All patients had chest pain and electrocardiographic ST segment elevation or depression during balloon inflation and higher peak elevation of cTnT in the CS than in the FV (0.054 +/- 0.059 vs 0.036 +/- 0.022 ng/mL; P < 0.05).
Positive_regulation (elevation) of cTnT in chest associated with angina and depression
1) Confidence 0.69 Published 2000 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 10696523 Disease Relevance 0.51 Pain Relevance 0.55
Accordingly, we aimed to understand the prevalence, determinants, and prognostic implications of cardiac troponin T (cTnT) elevations measured with a high-sensitivity assay in patients with T2DM.


Positive_regulation (elevations) of cTnT associated with diabetes mellitus
2) Confidence 0.31 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2946276 Disease Relevance 0.86 Pain Relevance 0
Elevations of cTnT above the 99th percentile measured by a highly sensitive assay were encountered frequently in a population of T2DM patients. cTnT levels appeared to be stable over time and associated with conventional CV risk factors.
Positive_regulation (Elevations) of cTnT associated with diabetes mellitus
3) Confidence 0.27 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2946276 Disease Relevance 0.51 Pain Relevance 0
The worst prognosis (nonfatal myocardial infarction or death) was noted in subjects with chest pain at rest within 48 h before the index examination and elevated cTnT levels.
Spec (examination) Positive_regulation (elevated) of cTnT in chest
4) Confidence 0.13 Published 1997 Journal Clin Cardiol Section Body Doc Link 9383587 Disease Relevance 0.24 Pain Relevance 0
Serum samples for cardiac troponin T (cTnT), creatine kinase-MB isozyme (CK-MB), myoglobin, and H-FABP were obtained from 64 patients with AMI and 53 patients with other conditions (control group).
Positive_regulation (cardiac) of cTnT associated with myocardial infarction
5) Confidence 0.08 Published 2010 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 20551280 Disease Relevance 0.43 Pain Relevance 0
Because increased excitability of sensory neurons may result in such pathological perceptions of pain as hyperalgesia and allodynia, upregulation of T-type Ca2+ currents and enhanced Ca2+ entry into these cells could contribute to the development of symptoms in diabetic neuropathy.
Positive_regulation (upregulation) of T-type in sensory neurons associated with pain, hyperalgesia, allodynia and diabetic neuropathy
6) Confidence 0.06 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17376991 Disease Relevance 1.07 Pain Relevance 0.61
Although the concentrations of cTnT and IMA were not statistically increased in PAD patients, NT-pro-BNP values were substantially higher in PAD patients than in controls (62.6 vs. 7.4 pmol/L, p<0.0001).
Neg (not) Positive_regulation (increased) of cTnT associated with peripheral arterial disease
7) Confidence 0.03 Published 2006 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 16475909 Disease Relevance 1.98 Pain Relevance 0.21

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