INT72472

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Context Info
Confidence 0.68
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.07
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRL1) signal transducer activity (OPRL1)
Anatomy Link Frequency
amygdala 4
Melanophores 2
C cells 2
ovary 2
OPRL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 11 100.00 Very High Very High Very High
amygdala 4 100.00 Very High Very High Very High
orphanin 15 99.98 Very High Very High Very High
opiate 1 99.44 Very High Very High Very High
Opioid 13 99.20 Very High Very High Very High
cannabis 6 99.12 Very High Very High Very High
Kinase C 3 98.84 Very High Very High Very High
alcohol 6 97.36 Very High Very High Very High
agonist 5 94.56 High High
Morphine 2 93.92 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 1 66.28 Quite High
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nociceptin activation of the human ORL1 receptor expressed in Chinese hamster ovary cells: functional homology with opioid receptors.
Positive_regulation (activation) of Gene_expression (expressed) of ORL1 in ovary associated with orphanin and opioid receptor
1) Confidence 0.68 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.46
Protein kinase C (PKC), but not ERK1/2, inhibition blocked OFQ/N-mediated GRK3 induction and mu and ORL1 receptor desensitization in BE(2)-C cells.
Positive_regulation (induction) of Gene_expression (desensitization) of ORL1 receptor in C cells associated with kinase c
2) Confidence 0.47 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423667 Disease Relevance 0.07 Pain Relevance 0.52
Melanophores were transfected with the human opioid receptor 3 and used for opiate detection.
Positive_regulation (transfected) of Gene_expression (transfected) of opioid receptor 3 in Melanophores associated with opiate and opioid receptor
3) Confidence 0.32 Published 2002 Journal Biosens Bioelectron Section Abstract Doc Link 11849930 Disease Relevance 0 Pain Relevance 0.71
Prenatal cannabis exposure was significantly associated with increased mu receptor expression in the amygdala, reduced kappa receptor mRNA in mediodorsal thalamic nucleus and reduced preproenkephalin expression in the caudal putamen.
Positive_regulation (increased) of Gene_expression (expression) of kappa receptor mRNA in amygdala associated with cannabis and amygdala
4) Confidence 0.25 Published 2006 Journal Pharmacogenomics J. Section Abstract Doc Link 16477274 Disease Relevance 0 Pain Relevance 0.84
Prenatal cannabis exposure was significantly associated with increased mu receptor expression in the amygdala, reduced kappa receptor mRNA in mediodorsal thalamic nucleus and reduced preproenkephalin expression in the caudal putamen.
Positive_regulation (increased) of Gene_expression (expression) of kappa receptor mRNA in amygdala associated with cannabis and amygdala
5) Confidence 0.25 Published 2006 Journal Pharmacogenomics J. Section Abstract Doc Link 16477274 Disease Relevance 0 Pain Relevance 0.87

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