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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 41
Total Number 44
Disease Relevance 28.62
Pain Relevance 17.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
blood 3
mononuclear cells 3
visceral 2
lymphocytes 2
macrophages 1
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 580 100.00 Very High Very High Very High
cytokine 357 100.00 Very High Very High Very High
glial activation 12 99.80 Very High Very High Very High
diclofenac 14 99.66 Very High Very High Very High
antagonist 58 98.80 Very High Very High Very High
Inflammatory mediators 25 98.72 Very High Very High Very High
tetrodotoxin 7 98.08 Very High Very High Very High
intrathecal 70 97.98 Very High Very High Very High
Neuritis 5 97.80 Very High Very High Very High
isoflurane 12 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 613 100.00 Very High Very High Very High
Cancer 64 100.00 Very High Very High Very High
Necrosis 31 100.00 Very High Very High Very High
Pulmonary Disease 26 100.00 Very High Very High Very High
Targeted Disruption 22 100.00 Very High Very High Very High
Infection 37 98.80 Very High Very High Very High
Stress 266 98.60 Very High Very High Very High
Hypersensitivity 259 98.48 Very High Very High Very High
Neuropathic Pain 142 98.14 Very High Very High Very High
Experimental Autoimmune Neuritis 5 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it remains unknown whether NE affects the release of other inflammatory cytokines such as IL-1beta and IL-10 and, if so, whether alpha(2)-AR is also involved in such a process.
Localization (release) of IL-10 associated with inflammation and cytokine
1) Confidence 0.78 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15949713 Disease Relevance 0.25 Pain Relevance 0.23
Immunohistochemistry was used to examine spinal localization of the cytokines, interleukin (IL)-6, IL-10 and glial activation (OX-42 for microglia and anti-glial fibrillary acidic protein for astrocytes).
Spec (examine) Localization (localization) of IL-10 in astrocytes associated with glial activation and cytokine
2) Confidence 0.73 Published 1997 Journal Eur J Pain Section Abstract Doc Link 15102412 Disease Relevance 0.07 Pain Relevance 0.48
Similarly, IL-1beta and IL-10 gene expression and release from KC were up-regulated by NE stimulation, whereas YHB attenuated both cytokines.
Localization (release) of IL-10 associated with cytokine
3) Confidence 0.69 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15949713 Disease Relevance 0.14 Pain Relevance 0.24
In contrast, estradiol caused an increase in IL-10 and NO release by cultured-BAL cells.
Localization (release) of IL-10
4) Confidence 0.62 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2936382 Disease Relevance 0.86 Pain Relevance 0.11
Subsequent to this examination, blood samples were collected to determine release of the cytokines tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6 and IL-10.
Spec (determine) Localization (release) of IL-10 in blood associated with necrosis, cancer and cytokine
5) Confidence 0.58 Published 2007 Journal Lab. Anim. Section Abstract Doc Link 17234050 Disease Relevance 0.20 Pain Relevance 0.26
and interleukin 10 (IL-10) release by cultured cells
Localization (release) of interleukin 10
6) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.02 Pain Relevance 0.09
and interleukin 10 (IL-10) release by cultured cells
Localization (release) of IL-10
7) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.01 Pain Relevance 0.09
On the 14th day after immunization, we examined lymphocyte proliferation, fractions of CD4+ T cells within lymph node mononuclear cells (MNC), frequencies of CD4+CD25+ T cells within CD4+ T cells, supernatant productions of IFN-gamma, IL-4, IL-10 and TGF-beta1 secreted by lymphocytes.
Localization (secreted) of IL-10 in mononuclear cells associated with immunization
8) Confidence 0.52 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17346805 Disease Relevance 0.33 Pain Relevance 0.12
The results demonstrated a significant decrease in interferon-gamma production and an increase in interleukin-10 secretion in heroin addicts, relative to the control group (35.9+/-26.3 versus 110.2+/-60.3 pg/mL, p<0.01 and 71.8+/-28.4 versus 17.1+/-13.5 pg/mL, p<0.01, respectively), however the changes in these values in opium addicts were not significant compared to healthy individuals.
Localization (secretion) of interleukin-10
9) Confidence 0.51 Published 2007 Journal Eur. Cytokine Netw. Section Abstract Doc Link 17993452 Disease Relevance 0.16 Pain Relevance 0.64
The beneficial effects were associated with profound modifications of the capacity of these rats to produce and release pro- and anti-inflammatory cytokines such as IFN-gamma, TNF-alpha and IL-10, which are important in regulating the development of EAN.
Localization (release) of IL-10 associated with inflammation, neuritis and cytokine
10) Confidence 0.47 Published 1999 Journal J. Autoimmun. Section Abstract Doc Link 10479387 Disease Relevance 0.87 Pain Relevance 0.45
APAP by itself did not alter release of TNF-alpha, PGE(2), IL-10, Gro/KC or IFN-gamma; however, in the presence of LPS, APAP enhanced LPS-induced TNF-alpha and Gro/KC release.
Localization (release) of IL-10
11) Confidence 0.46 Published 2006 Journal Toxicol In Vitro Section Abstract Doc Link 16782301 Disease Relevance 0.39 Pain Relevance 0.27
The mutant also decreased the activation-induced release of TNF and IFN-gamma from mesenteric T cells and the IL-10 concentration in colonic tissue, while increasing the activation-induced secretion of IL-10 in splenocytes and mesenteric lymphocytes and the baseline IL-10 release of splenocytes.
Localization (release) of IL-10 in lymphocytes
12) Confidence 0.45 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18312544 Disease Relevance 0.49 Pain Relevance 0.56
The mutant also decreased the activation-induced release of TNF and IFN-gamma from mesenteric T cells and the IL-10 concentration in colonic tissue, while increasing the activation-induced secretion of IL-10 in splenocytes and mesenteric lymphocytes and the baseline IL-10 release of splenocytes.
Localization (secretion) of IL-10 in lymphocytes
13) Confidence 0.45 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18312544 Disease Relevance 0.51 Pain Relevance 0.55
One of the mechanisms by which Tregs mediate their suppressive effect is by secreting inhibitory cytokines such as IL-10.
Localization (secreting) of IL-10 associated with cytokine
14) Confidence 0.44 Published 2010 Journal Journal of Neuroinflammation Section Body Doc Link PMC3022819 Disease Relevance 0.44 Pain Relevance 0.23
For instance, the anti-inflammatory interleukin 10 (IL-10) secreted by human subcutaneous and visceral adipose depots is more expressed in the latter [6].
Localization (secreted) of interleukin 10 in visceral associated with inflammation
15) Confidence 0.40 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 1.20 Pain Relevance 0.38
For instance, the anti-inflammatory interleukin 10 (IL-10) secreted by human subcutaneous and visceral adipose depots is more expressed in the latter [6].
Localization (secreted) of IL-10 in visceral associated with inflammation
16) Confidence 0.40 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 1.20 Pain Relevance 0.37
The purpose of the present series of studies was to explore a new approach to neuropathic pain control; that is, intrathecal gene therapy using an adeno-associated viral (serotype II; AAV2) vector to drive the production and release of interleukin-10 (IL-10), a powerful anti-inflammatory cytokine [19].
Localization (release) of IL-10 associated with inflammation, neuropathic pain, cytokine and intrathecal
17) Confidence 0.39 Published 2005 Journal Mol Pain Section Body Doc Link PMC1079940 Disease Relevance 1.88 Pain Relevance 1.60
The purpose of the present series of studies was to explore a new approach to neuropathic pain control; that is, intrathecal gene therapy using an adeno-associated viral (serotype II; AAV2) vector to drive the production and release of interleukin-10 (IL-10), a powerful anti-inflammatory cytokine [19].
Localization (release) of interleukin-10 associated with inflammation, neuropathic pain, cytokine and intrathecal
18) Confidence 0.39 Published 2005 Journal Mol Pain Section Body Doc Link PMC1079940 Disease Relevance 1.87 Pain Relevance 1.59
IL-10 is an immuno-suppressant that is mainly secreted by regulatory T cells.
Localization (secreted) of IL-10 in regulatory T cells
19) Confidence 0.39 Published 2010 Journal Journal of Neuroinflammation Section Body Doc Link PMC3022819 Disease Relevance 0.41 Pain Relevance 0.09
AIM: We hypothesized that ketoprofen would affect release of IL-6 and IL-10 and modulate the immune response.
Localization (release) of IL-10
20) Confidence 0.39 Published 2007 Journal Akush Ginekol (Sofiia) Section Body Doc Link 17469457 Disease Relevance 0 Pain Relevance 0

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