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Context Info
Confidence 0.40
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 41
Total Number 45
Disease Relevance 63.74
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 4
CPA 1
internal 1
liver parenchyma 1
HCC (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 141 99.72 Very High Very High Very High
palliative 15 98.52 Very High Very High Very High
alcohol 58 98.32 Very High Very High Very High
cINOD 23 94.56 High High
abdominal pain 8 93.84 High High
imagery 299 88.72 High High
Inflammation 188 87.84 High High
Bile 95 87.44 High High
Inflammatory response 8 84.64 Quite High
cytokine 159 84.32 Quite High
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 1565 100.00 Very High Very High Very High
Familial Adenomatous Polyposis 730 100.00 Very High Very High Very High
Cirrhosis 318 100.00 Very High Very High Very High
Carcinoma 278 100.00 Very High Very High Very High
Recurrence 88 100.00 Very High Very High Very High
Colon Cancer 63 100.00 Very High Very High Very High
Hepatitis Virus Infection 34 100.00 Very High Very High Very High
Stomach Cancer 19 100.00 Very High Very High Very High
Esophageal Cancer 14 100.00 Very High Very High Very High
Pancreatic Cancer 11 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most frequent underlying factors causing HCC are chronic viral hepatitis and cirrhosis.
Positive_regulation (causing) of HCC associated with cirrhosis, hepatocellular cancer and hepatitis virus infection
1) Confidence 0.40 Published 2002 Journal J Vasc Interv Radiol Section Abstract Doc Link 12354833 Disease Relevance 0.87 Pain Relevance 0.13
In the United States, the incidence of HCC has increased by nearly 75% since the 1980s.
Positive_regulation (increased) of HCC associated with hepatocellular cancer
2) Confidence 0.40 Published 2004 Journal Clin J Oncol Nurs Section Abstract Doc Link 15354926 Disease Relevance 0.93 Pain Relevance 0.03
More than 60 articles reporting on clinical outcomes among patients who received RT for HCC have been published since 1990, including 20 articles that described unique sets of at least 15 patients.
Positive_regulation (received) of HCC associated with hepatocellular cancer
3) Confidence 0.39 Published 2006 Journal Cancer Section Abstract Doc Link 16541431 Disease Relevance 0.92 Pain Relevance 0.08
Furthermore, alcoholic cirrhosis with occult hepatitis B virus infection increased the risk of HCC.
Positive_regulation (increased) of HCC associated with hepatocellular cancer, alcoholic liver cirrhosis, infection and hepatitis
4) Confidence 0.35 Published 2009 Journal Korean J Hepatol Section Abstract Doc Link 20037277 Disease Relevance 1.88 Pain Relevance 0.21
Cirrhosis, elevated alpha-fetoprotein levels, and risk factors for HCC such as viral hepatitis are typically absent.
Positive_regulation (elevated) of HCC associated with cirrhosis, hepatocellular cancer and hepatitis virus infection
5) Confidence 0.30 Published 2007 Journal Ann Ital Chir Section Abstract Doc Link 17518332 Disease Relevance 1.63 Pain Relevance 0.06
Between March 1998 and December 2007, five patients who underwent LDLT for HCC were identified with a routine follow-up of pulmonary metastases: Two patients underwent a radical resection for pulmonary recurrence of HCC, Two patients were only observed by palliative treatment, and one patient had chemotherapy using S-1/IFN.
Positive_regulation (underwent) of HCC associated with hepatocellular cancer, recurrence, metastasis and palliative
6) Confidence 0.25 Published 2008 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 19106532 Disease Relevance 1.00 Pain Relevance 0.10
Despite this poor prognosis, many therapeutic options are available for HCC patients.
Positive_regulation (available) of HCC
7) Confidence 0.25 Published 2009 Journal Bull Cancer Section Abstract Doc Link 19211357 Disease Relevance 0.69 Pain Relevance 0.09
Raf kinase inhibitors such as sorafenib have been proved to exert anti-tumoral activity in patients with advanced HCC [40].
Positive_regulation (advanced) of HCC associated with carcinoma
8) Confidence 0.24 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.93 Pain Relevance 0
Other distinct clinicopathological types discussed in this paper include diffuse-type HCC which is usually caused by multiple portal spread occurring almost simultaneously; the clinical course is fulminant.
Positive_regulation (caused) of HCC associated with hepatocellular cancer
9) Confidence 0.24 Published 1997 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 9407352 Disease Relevance 1.51 Pain Relevance 0
Individuals with most types of cirrhosis of the liver are at an increased risk of developing HCC.
Positive_regulation (increased) of HCC in liver associated with cirrhosis and hepatocellular cancer
10) Confidence 0.23 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921257 Disease Relevance 2.97 Pain Relevance 0.03
The way in which HCV causes HCC is not well understood.4
Positive_regulation (causes) of HCC associated with hepatocellular cancer and hepatitis c virus infection
11) Confidence 0.23 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921257 Disease Relevance 2.75 Pain Relevance 0.05
The same applied for Jak2 inhibitors, although Jak2 has been shown to be ubiquitously activated in human HCC [38].
Positive_regulation (activated) of HCC associated with carcinoma
12) Confidence 0.22 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.33 Pain Relevance 0
of human cancers, including HCC, which show the accumulation of p-RXR?
Positive_regulation (accumulation) of HCC associated with cancer and carcinoma
13) Confidence 0.19 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 1.12 Pain Relevance 0.04
Depending on the tumor vascularity, some tumors may enhance stronger and some may enhance weaker than normal liver parenchyma as also known for gadolinium chelates (Figures 3 and 4).53,54 Gadoxetic acid has the potential capacity for the concurrent assessment of vascularity of HCC and hepatocellular-specific properties within the tumor.55 Persisting enhancement during the accumulation phase has been subject to experimental and clinical reports.56 Fujita et al57 described potential enhancement of moderately differentiated HCCs in a mice model.
Spec (may) Positive_regulation (enhance) of HCC in liver parenchyma associated with cancer and hepatocellular cancer
14) Confidence 0.17 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921257 Disease Relevance 1.07 Pain Relevance 0.08
In summary, APC gene mutations do not seem to play an important role in the inactivation of APC in HCC.
Positive_regulation (inactivation) of HCC associated with hepatocellular cancer and familial adenomatous polyposis
15) Confidence 0.15 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.77 Pain Relevance 0
These findings suggest that quantitative epigenetic changes are probably of clinical significance in hepatocarcinogenesis, but further post-transcriptional mechanisms must also be responsible for inactivation of the APC gene in HCC.
Positive_regulation (inactivation) of HCC associated with hepatocellular cancer and familial adenomatous polyposis
16) Confidence 0.13 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.77 Pain Relevance 0.05
Synchronous occurrence of different risk factors, such as chronic viral hepatitis and aflatoxin burden or iron overload in a single patient or patient population increases the risk of developing HCC.
Positive_regulation (increases) of HCC associated with hepatocellular cancer, hepatitis virus infection and iron overload
17) Confidence 0.13 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 0.87 Pain Relevance 0
Preliminary reports suggest that the APC promoter is methylated in up to 81% of patients with viral hepatitis-induced HCC using the methylation-specific polymerase chain reaction (MSP) (Lee et al. 2003; Yang et al. 2003).
Positive_regulation (induced) of HCC associated with hepatocellular cancer, familial adenomatous polyposis and hepatitis virus infection
18) Confidence 0.13 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.02 Pain Relevance 0
The clinical impact of transcriptional silencing of the APC gene induced by promoter methylation in HCC is currently unclear.
Positive_regulation (induced) of HCC associated with hepatocellular cancer and familial adenomatous polyposis
19) Confidence 0.13 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.33 Pain Relevance 0
Because promoter methylation is significantly enhanced in HCC compared to that of non-tumor samples, and APC expression is also significantly reduced in liver cancer cells, higher degrees of promoter methylation of the APC gene seem to be responsible for the reduced APC protein expression in HCC.
Positive_regulation (enhanced) of HCC in liver associated with liver cancer, cancer, familial adenomatous polyposis and hepatocellular cancer
20) Confidence 0.13 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.97 Pain Relevance 0

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