INT72936

From wiki-pain
Revision as of 10:27, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 1998
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 39
Total Number 41
Disease Relevance 19.01
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Anatomy Link Frequency
granulosa cells 4
Peritoneal macrophages 3
ovary 3
macrophages 2
stellate cells 2
Pparg (Rattus norvegicus)
Pparg - P12A (3)
Pain Link Frequency Relevance Heat
cytokine 12 100.00 Very High Very High Very High
qutenza 14 98.20 Very High Very High Very High
cINOD 29 98.00 Very High Very High Very High
antagonist 50 97.76 Very High Very High Very High
metalloproteinase 14 96.92 Very High Very High Very High
fibrosis 23 93.40 High High
Chronic pancreatitis 8 92.12 High High
Inflammation 12 87.72 High High
Inflammatory mediators 2 85.80 High High
agonist 58 85.44 High High
Disease Link Frequency Relevance Heat
Cardiovascular Disease 128 100.00 Very High Very High Very High
Atherosclerosis 19 100.00 Very High Very High Very High
Repression 6 99.92 Very High Very High Very High
Myocardial Infarction 153 99.80 Very High Very High Very High
Obesity 113 99.56 Very High Very High Very High
Shock 4 99.56 Very High Very High Very High
Death 51 99.40 Very High Very High Very High
Pheochromocytoma 12 99.06 Very High Very High Very High
Stress 51 98.98 Very High Very High Very High
Apoptosis 14 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is constitutively expressed in primary cultures of rat microglia, the main population of brain resident macrophages, and its ligand-dependent activation leads to the repression of several microglial functions.
Gene_expression (expressed) of PPAR-gamma in macrophages associated with repression
1) Confidence 0.77 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15686492 Disease Relevance 0.31 Pain Relevance 0.33
Induction of PPARgamma expression strongly inhibited proliferation and enhanced the rate of apoptotic cell death.
Gene_expression (expression) of PPARgamma in apoptotic cell associated with apoptosis and death
2) Confidence 0.77 Published 2005 Journal J. Cell. Mol. Med. Section Abstract Doc Link 16202214 Disease Relevance 0.57 Pain Relevance 0.10
Furthermore, PPARgamma-overexpressing cells synthesised less collagen than controls.
Gene_expression (overexpressing) of PPARgamma
3) Confidence 0.77 Published 2005 Journal J. Cell. Mol. Med. Section Abstract Doc Link 16202214 Disease Relevance 0.57 Pain Relevance 0.10
Using stringent selection criteria, we identified 21 up- and 19 down-regulated genes in PPARgamma-overexpressing cells.
Gene_expression (overexpressing) of PPARgamma
4) Confidence 0.77 Published 2005 Journal J. Cell. Mol. Med. Section Abstract Doc Link 16202214 Disease Relevance 0.50 Pain Relevance 0.08
Using immortalised rat PSCs, we have established a model of tetracycline (tet)-regulated PPARgamma overexpression.
Gene_expression (overexpression) of PPARgamma in PSCs
5) Confidence 0.77 Published 2005 Journal J. Cell. Mol. Med. Section Abstract Doc Link 16202214 Disease Relevance 0.56 Pain Relevance 0.11
Peroxisome proliferator-activated receptor gamma overexpression inhibits pro-fibrogenic activities of immortalised rat pancreatic stellate cells.
Gene_expression (overexpression) of Peroxisome proliferator-activated receptor gamma in stellate cells
6) Confidence 0.77 Published 2005 Journal J. Cell. Mol. Med. Section Title Doc Link 16202214 Disease Relevance 0.52 Pain Relevance 0.14
The role of FSH in the induction of PPARgamma expression was further assessed in ovarian tissue from FORKO mice.
Gene_expression (expression) of PPARgamma
7) Confidence 0.73 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2795759 Disease Relevance 0 Pain Relevance 0.05
To determine when PPARgamma expression is initiated, ovaries were collected from neonatal rats.
Spec (determine) Gene_expression (expression) of PPARgamma in ovaries
8) Confidence 0.73 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2795759 Disease Relevance 0 Pain Relevance 0.03
We tested the hypothesis that high levels of FSH during the neonatal period trigger the expression of PPARgamma.
Gene_expression (expression) of PPARgamma
9) Confidence 0.73 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2795759 Disease Relevance 0 Pain Relevance 0.03
Treatment of PC12 cells with a proapoptotic dose of SNP induced expression of both COX-2 and PPARgamma.
Gene_expression (expression) of PPARgamma associated with pheochromocytoma
10) Confidence 0.69 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15033806 Disease Relevance 1.19 Pain Relevance 0.24
It has been reported that the expression of cyclooxygenase-2 (COX-2) and peroxisome proliferator-activated receptor-gamma (PPARgamma) is elevated in Alzheimer's disease, and certain nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the risk and delay the onset of Alzheimer's disease.
Gene_expression (expression) of PPARgamma associated with inflammation, cinod and disease
11) Confidence 0.69 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15033806 Disease Relevance 1.30 Pain Relevance 0.23
The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is constitutively expressed in primary cultures of rat microglia, the main population of brain resident macrophages, and its ligand-dependent activation leads to the repression of several microglial functions.
Gene_expression (expressed) of proliferator-activated receptor-gamma in macrophages associated with repression
12) Confidence 0.67 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15686492 Disease Relevance 0.31 Pain Relevance 0.33
Initiation of the expression of peroxisome proliferator - activated receptor gamma (PPAR gamma) in the rat ovary and the role of FSH

PPARgamma is highly expressed in granulosa cells by 23 days post-partum (pp) and is down-regulated in response to the LH surge.

Gene_expression (expression) of proliferator - activated receptor gamma in ovary
13) Confidence 0.64 Published 2009 Journal Reprod Biol Endocrinol Section Title Doc Link PMC2795759 Disease Relevance 0 Pain Relevance 0.03
Initiation of the expression of peroxisome proliferator - activated receptor gamma (PPAR gamma) in the rat ovary and the role of FSH

PPARgamma is highly expressed in granulosa cells by 23 days post-partum (pp) and is down-regulated in response to the LH surge.

Gene_expression (expressed) of PPARgamma in granulosa cells
14) Confidence 0.63 Published 2009 Journal Reprod Biol Endocrinol Section Title Doc Link PMC2795759 Disease Relevance 0 Pain Relevance 0.03
It has been reported that the expression of cyclooxygenase-2 (COX-2) and peroxisome proliferator-activated receptor-gamma (PPARgamma) is elevated in Alzheimer's disease, and certain nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the risk and delay the onset of Alzheimer's disease.
Gene_expression (expression) of peroxisome proliferator-activated receptor-gamma associated with inflammation, cinod and disease
15) Confidence 0.60 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15033806 Disease Relevance 1.30 Pain Relevance 0.23
Expression of PPAR-gamma is an early and pivotal event in the differentiation of adipocytes.
Gene_expression (Expression) of PPAR-gamma in adipocytes associated with obesity
16) Confidence 0.57 Published 1998 Journal Nature Section Abstract Doc Link 9422509 Disease Relevance 0.49 Pain Relevance 0.41
In summary, the FSH/FSH receptor system is present in granulosa cells prior to the onset of expression of PPARgamma.
Gene_expression (expression) of PPARgamma in granulosa cells
17) Confidence 0.57 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2795759 Disease Relevance 0 Pain Relevance 0.04
These data indicate that FSH is not a primary factor initiating the expression of PPARgamma and that other agents play a role in activating its expression in the ovary.



Gene_expression (expression) of PPARgamma in ovary
18) Confidence 0.57 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2795759 Disease Relevance 0 Pain Relevance 0.04
Reducing FSH during the neonatal period, or the ability to respond to FSH, did not decrease expression of mRNA for PPARgamma.
Gene_expression (expression) of PPARgamma
19) Confidence 0.57 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2795759 Disease Relevance 0 Pain Relevance 0.04
PPARgamma was detected in select granulosa cells in primary/early secondary follicles.
Gene_expression (detected) of PPARgamma in granulosa cells
20) Confidence 0.57 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2795759 Disease Relevance 0 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox