INT73011

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Context Info
Confidence 0.23
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.38
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde1b) nucleolus (Pde1b) nucleus (Pde1b)
cytoplasm (Pde1b)
Pde1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
allodynia 3 99.96 Very High Very High Very High
opiate 3 99.78 Very High Very High Very High
withdrawal 2 98.08 Very High Very High Very High
Opioid 2 96.04 Very High Very High Very High
opioid receptor 3 81.36 Quite High
Gabapentin 10 80.16 Quite High
anticonvulsant 1 73.44 Quite High
Dynorphin 2 70.16 Quite High
Neuropathic pain 2 60.64 Quite High
Nucleus accumbens 1 36.00 Quite Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 7 99.96 Very High Very High Very High
Pressure And Volume Under Development 2 25.00 Low Low
Pain 2 25.00 Low Low
Anxiety Disorder 1 25.00 Low Low
INFLAMMATION 44 5.00 Very Low Very Low Very Low
Pulmonary Disease 31 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Hypertension 5 5.00 Very Low Very Low Very Low
Vomiting 5 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDE1B expression is lower than other members of the PDE1 family.
Gene_expression (expression) of PDE1B
1) Confidence 0.23 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0
These anti-opiate peptides (AOP) are secreted or released into the CNS and produce diverse actions that counterbalance the effects of prolonged opiate exposure.
Gene_expression (produce) of AOP associated with opiate
2) Confidence 0.10 Published 1999 Journal Peptides Section Abstract Doc Link 10698116 Disease Relevance 0 Pain Relevance 0.55
Systemically administered, the anti-GD2 antibody produces allodynia demonstrated by decreased mechanical withdrawal threshold.
Gene_expression (produces) of anti-GD2 associated with allodynia and withdrawal
3) Confidence 0.10 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9428862 Disease Relevance 0.38 Pain Relevance 0.73

General Comments

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