INT73046

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.32
Pain Relevance 4.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Rere) nucleus (Rere) DNA binding (Rere)
Anatomy Link Frequency
tail 1
Rere (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 9 99.98 Very High Very High Very High
antagonist 12 99.94 Very High Very High Very High
Morphine 22 99.28 Very High Very High Very High
opioid receptor 7 99.14 Very High Very High Very High
agonist 4 97.84 Very High Very High Very High
dopamine receptor 8 97.32 Very High Very High Very High
tail-flick 3 96.44 Very High Very High Very High
Analgesic 3 94.16 High High
narcan 6 90.88 High High
antinociception 10 90.48 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 1 96.62 Very High Very High Very High
Pain 1 86.00 High High
Nociception 1 81.12 Quite High
Targeted Disruption 1 52.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Substrates containing only a single basic residue were not appreciably hydrolyzed, and substrates lacking a P4 Arg exhibited kcat of less than 0.05 s-1.
Negative_regulation (lacking) of Arg
1) Confidence 0.42 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9712897 Disease Relevance 0.05 Pain Relevance 0.29
To examine the role of mu-opioid receptor subtypes, we assessed the antinociceptive effect of H-Tyr-D-Arg-Phe-beta-Ala-OH (TAPA), an analogue of dermorphin N-terminal peptide in mice, using the tail-flick test.
Negative_regulation (effect) of Arg in tail associated with tail-flick, opioid receptor and antinociceptive
2) Confidence 0.41 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10794815 Disease Relevance 0 Pain Relevance 0.62
Male mice of the CD-1 strain were injected with different doses of the muscarinic agonist oxotremorine (0.005, 0.01, 0.02, 0.03 mg/kg i.p.) 5 min after the administration of saline solution or the inhibitors of NO synthase NG-nitro-L-arginine methyl ester (L-NAME: 10 and 20 mg/kg, i.p.) or NG-nitro-L-arginine (N-ARG: 10 and 20 mg/kg i.p.).
Negative_regulation (inhibitors) of N-ARG associated with agonist and sprains and strains
3) Confidence 0.08 Published 1997 Journal Pol J Pharmacol Section Abstract Doc Link 9431549 Disease Relevance 0.26 Pain Relevance 0.50
In the second part of the study, the animals received SCH23390 (D1 receptor antagonist), sulpiride (D2 receptor antagonist), L-Arg (nitric oxide precursor) and NG-nitro-L-Arg methylester (nitric oxide synthase inhibitor) during repeated morphine administration, to evaluate the role of dopamine receptor antagonists and nitric oxide agents in this phenomenon.
Negative_regulation (inhibitor) of L-Arg associated with dopamine receptor, antagonist and morphine
4) Confidence 0.02 Published 2007 Journal Behav Pharmacol Section Abstract Doc Link 17426481 Disease Relevance 0 Pain Relevance 1.59
In the second part of the study, the animals received SCH23390 (D1 receptor antagonist), sulpiride (D2 receptor antagonist), L-Arg (nitric oxide precursor) and NG-nitro-L-Arg methylester (nitric oxide synthase inhibitor) during repeated morphine administration, to evaluate the role of dopamine receptor antagonists and nitric oxide agents in this phenomenon.
Negative_regulation (inhibitor) of L-Arg associated with dopamine receptor, antagonist and morphine
5) Confidence 0.02 Published 2007 Journal Behav Pharmacol Section Abstract Doc Link 17426481 Disease Relevance 0 Pain Relevance 1.57

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