INT73080

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Context Info
Confidence 0.38
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.37
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TTF1) nucleolus (TTF1) nucleus (TTF1)
DNA binding (TTF1)
Anatomy Link Frequency
thyroid 1
TTF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 6 79.76 Quite High
Pain 4 75.00 Quite High
nud 2 25.00 Low Low
headache 2 25.00 Low Low
pruritus 1 25.00 Low Low
cva 4 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 3 98.32 Very High Very High Very High
Hepatocellular Cancer 22 96.48 Very High Very High Very High
Carcinoma 9 92.08 High High
Thyroid Neoplasm 4 89.60 High High
Obesity 1 87.84 High High
Liver Disease 3 87.28 High High
Cancer 35 82.92 Quite High
Hypoglycemia 1 82.68 Quite High
Adenocarcinoma 21 80.84 Quite High
Malignant Neoplastic Disease 13 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemically, these cells were positive for pankeratin, TTF-1 (shown as insert), Ber-EP4 and CEA; they were negative for calretinin, cytokeratin 5 and 6, S100 and Melan-A.
Positive_regulation (positive) of TTF-1
1) Confidence 0.38 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2734526 Disease Relevance 1.06 Pain Relevance 0.07
In our case, the thyroid sample was negative for TTF-1, CK 7, and CK 20, but positive for alpha-fetoprotein, which is relatively specific for HCC, although of low sensitivity [14].
Positive_regulation (negative) of TTF-1 in thyroid associated with hepatocellular cancer
2) Confidence 0.34 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2246133 Disease Relevance 1.00 Pain Relevance 0.07
The mechanisms of action of silymarin involve different biochemical events, such as the stimulation of the synthetic rate of ribosomal RNA (rRNA) species through stimulation of polymerase I and rRNA transcription, protecting the cell membrane from radical-induced damage and blockage of the uptake of toxins such as alpha-amanitin.
Positive_regulation (stimulation) of polymerase I and rRNA
3) Confidence 0.11 Published 2001 Journal BioDrugs Section Abstract Doc Link 11520257 Disease Relevance 0.14 Pain Relevance 0
Serum insulin-like growth factor-I (IGF-I) increased from a standard deviation score of -2.64 +/- 0.27 (range -8.8 +3.82; n = 78) to +1.08 +/- 2.87 (range -7.21 to +6.42) at 6 months in the GH/GH group; 38% of the whole group were above the age-specific reference range following treatment [17.6% and 68.9% with subnormal (< 2 SD) or normal (+/- 2 SD) pretreatment levels, respectively].
Positive_regulation (increased) of factor-I
4) Confidence 0.03 Published 1998 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9435425 Disease Relevance 0.16 Pain Relevance 0

General Comments

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