INT73088

Context Info Confidence 0.23 First Reported 1997 Last Reported 2000 Negated 1 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0.78 Pain Relevance 1.45

nucleolus (FLII) cytoskeleton (FLII) nucleus (FLII) cytoplasm (FLII)

Anatomy Link Frequency spinal cord 1 brainstem 1 FLII (Homo sapiens)

Pain Link Frequency Relevance Heat medulla 2 99.68 antagonist 9 99.46 Cholecystokinin 9 99.22 qutenza 3 98.76 Nicotine 9 97.76 Locus ceruleus 2 75.00 agonist 1 69.60 opiate 1 68.92 Cannabinoid 3 50.00 Spinal cord 1 50.00

Disease Link Frequency Relevance Heat Vomiting 12 99.04 Gagging 1 79.12 Pain 1 46.48 Nociception 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Effects of the cannabinoid agonist, CP55,940 (80 micrograms ith) on formalin pain and FLI in rat spinal cord were compared with that of the prototypic narcotic analgesic, morphine (20 micrograms ith).

Regulation (Effects) of FLI in spinal cord

1) Confidence 0.23 Published 1999 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 11216448 Disease Relevance 0 Pain Relevance 0

Pretreatment with either mecamylamine or the high (1%) concentration of atropine significantly reduced nicotine-evoked FLI in these areas, while pretreatment with the low (0.1%) atropine concentration did not significantly affect FLI.

Neg (not) Regulation (affect) of FLI associated with nicotine

2) Confidence 0.08 Published 2000 Journal Exp Brain Res Section Abstract Doc Link 10883386 Disease Relevance 0 Pain Relevance 0.46

After capsaicin pretreatment, both CCK antagonists had additional inhibitory effects only on FLI in the AP.

Regulation (effects) of FLI associated with qutenza, antagonist and cholecystokinin

3) Confidence 0.04 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9435662 Disease Relevance 0 Pain Relevance 0.76

Although CP-99,994 (1 mg/kgx2) abolished the loperamide-induced emesis, it did not have any statistically significant effect on FLI in the brainstem.

Regulation (effect) of FLI in brainstem associated with medulla and vomiting

4) Confidence 0.00 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10670427 Disease Relevance 0.78 Pain Relevance 0.22

General Comments

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