INT73117

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 10.31
Pain Relevance 5.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (DNMT3B) nucleus (DNMT3B) DNA binding (DNMT3B)
cytoplasm (DNMT3B)
Anatomy Link Frequency
primary motor cortex 1
muscle 1
DNMT3B (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 14 99.60 Very High Very High Very High
nerve block 16 99.54 Very High Very High Very High
backache 97 99.28 Very High Very High Very High
cannabis 364 98.80 Very High Very High Very High
Transcranial magnetic stimulation 283 98.78 Very High Very High Very High
Nicotine 21 97.64 Very High Very High Very High
Ventral tegmentum 7 96.80 Very High Very High Very High
Pyramidal cell 14 95.60 Very High Very High Very High
imagery 3 92.52 High High
Deafferentation 6 92.08 High High
Disease Link Frequency Relevance Heat
Schizophrenia 742 99.84 Very High Very High Very High
Drug Dependence 301 99.72 Very High Very High Very High
Low Back Pain 99 99.44 Very High Very High Very High
Hyponatremia 8 99.36 Very High Very High Very High
Cannabis Dependence 168 98.92 Very High Very High Very High
Cerebral Infarction 45 98.36 Very High Very High Very High
Sleep Disorders 33 96.52 Very High Very High Very High
Disease 72 94.32 High High
Dysesthesia 9 93.20 High High
Hypernatremia 2 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ICF Core Sets for patients with a determined health condition represent a selection of ICF categories out of the whole classification that can serve as minimal standards for the reporting of functioning and health for clinical studies and clinical encounters (Brief ICF Core Set) or as standards for multiprofessional, comprehensive assessment (Comprehensive ICF Core Set) under consideration of influential Environmental Factors.
Positive_regulation (selection) of ICF
1) Confidence 0.47 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779412 Disease Relevance 0.08 Pain Relevance 0.04
The main result of our study is that schizophrenia patients with a history of cannabis abuse (SZ-SUD) showed a reduced GABAA-mediated SICI and an enhanced ICF compared to patients with no cannabis abuse history (SZ-NSUD).
Positive_regulation (enhanced) of ICF associated with drug dependence, cannabis and schizophrenia
2) Confidence 0.40 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 1.34 Pain Relevance 0.45
Reduction of SICI and increase of ICF in SZ-SUD compared to SZ-NSUD patients were not significant when stimulating the left primary motor cortex (for details see Table 2).
Positive_regulation (increase) of ICF in primary motor cortex associated with drug dependence and schizophrenia
3) Confidence 0.35 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 1.29 Pain Relevance 0.07
The task of developing a measurement system to map onto the ICF is thus an ongoing challenge, and the current study offers one potential way of providing measurement that facilitates an ICF based CAT approach.
Positive_regulation (based) of ICF
4) Confidence 0.31 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651163 Disease Relevance 0.09 Pain Relevance 0
In our study, patients with a double diagnosis showed an enhanced ICF.
Positive_regulation (enhanced) of ICF
5) Confidence 0.27 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 0.15 Pain Relevance 0.79
A number of TMS studies have now found reduced intracortical inhibition and enhanced ICF in schizophrenia patients (Daskalakis et al. 2002; Eichhammer et al. 2004; Fitzgerald et al. 2002a,b,c; Pascual-Leone et al. 2002; Wobrock et al. 2008).
Positive_regulation (enhanced) of ICF associated with transcranial magnetic stimulation and schizophrenia
6) Confidence 0.25 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 1.17 Pain Relevance 0.34
0.001] and a significant increase of ICF [F(1,19)?
Positive_regulation (increase) of ICF
7) Confidence 0.25 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 1.35 Pain Relevance 0.13
INB alone had no effect on ICI or ICF, whereas INB+rTMSc reduced ICI and increased ICF, and conversely, INB+rTMSi deepened ICI and suppressed ICF. rTMSi and rTMSc alone were ineffective in changing any of these parameters.
Positive_regulation (increased) of ICF associated with nerve block
8) Confidence 0.24 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9437031 Disease Relevance 0 Pain Relevance 1.58
Likewise, atropine, a cholinergic antagonist, has been found to enhance ICF (Liepert et al. 2001), while NMDA antagonists and chronic nicotine exposure have been associated with an ICF reduction (Lang et al. 2008; Schwenkreis et al. 1999; Ziemann et al. 1998).
Positive_regulation (enhance) of ICF associated with nicotine and antagonist
9) Confidence 0.24 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 0.16 Pain Relevance 0.78
This suggests lower cortical inhibition and increased ICF in first-episode SZ with previous cannabis abuse.
Positive_regulation (increased) of ICF associated with cannabis and schizophrenia
10) Confidence 0.24 Published 2009 Journal Psychopharmacology (Berl) Section Abstract Doc Link PMC2806533 Disease Relevance 2.03 Pain Relevance 0.45
The Comprehensive ICF Core Set represents a broader perspective to the problems of the LBP patients, as was the intention for the development of the ICF (WHO 2001).
Positive_regulation (development) of ICF associated with backache
11) Confidence 0.21 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.32 Pain Relevance 0.32
An advancement of the ICF, compared with previous classification tools, was to incorporate contextual factors, including physical and social environmental factors as well as personal factors (e.g. age, education, coping styles), into a model of functioning and disability.
Positive_regulation (advancement) of ICF
12) Confidence 0.19 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2245913 Disease Relevance 0 Pain Relevance 0.04
From a methodological point of view, while the quality of linking was assured, the identification of meaningful concepts and coding based on the ICF not only requires of the linkers an in depth understanding of the ICF but also experience in linking.
Positive_regulation (requires) of ICF
13) Confidence 0.06 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC3022566 Disease Relevance 0.25 Pain Relevance 0
[Testing of ICF core set for low back pain].
Positive_regulation ([Testing) of ICF associated with low back pain and backache
14) Confidence 0.04 Published 2008 Journal Tidsskr. Nor. Laegeforen. Section Title Doc Link 19079415 Disease Relevance 0.19 Pain Relevance 0.19
MATERIAL AND METHOD: Health professionals used ICF core sets to rate patient problems within the 78 categories.
Positive_regulation (used) of ICF
15) Confidence 0.04 Published 2008 Journal Tidsskr. Nor. Laegeforen. Section Body Doc Link 19079415 Disease Relevance 0 Pain Relevance 0
Therefore, it is possible that increased ICF after the control stimulation, but not after the active stimulation, could reflect differences in non-specific changes in arousal across the two conditions.
Neg (not) Positive_regulation (increased) of ICF
16) Confidence 0.03 Published 2008 Journal Clinics Section Body Doc Link PMC2664271 Disease Relevance 0.59 Pain Relevance 0.03
For instance, ICF has been found to increase in the unaffected hemisphere in chronic stroke patients submitted to constraint-induced therapy for ten days.20 Kimberley and colleagues1 reported improved JTT performance, and enhanced functional magnetic resonance imaging (fMRI) activity in the primary sensory cortex in the unaffected hemisphere of chronic stroke patients submitted to somatosensory stimulation in the form of electrical muscle stimulation of the forearm extensor muscles for three weeks.
Neg (unaffected) Positive_regulation (increase) of ICF in muscle associated with cerebral infarction and imagery
17) Confidence 0.03 Published 2008 Journal Clinics Section Body Doc Link PMC2664271 Disease Relevance 0.42 Pain Relevance 0.05
There was a significant increase in ICF after control somatosensory stimulation (p<0.01) and no significant changes after active somatosensory stimulation (p = 0.32).
Positive_regulation (increase) of ICF
18) Confidence 0.03 Published 2008 Journal Clinics Section Body Doc Link PMC2664271 Disease Relevance 0.42 Pain Relevance 0.06
Hyponatremia is correlated with a sustained increase in the ICF volume caused by the osmotic gradient generated between the ECF [Na+] and ICF [K+].
Positive_regulation (increase) of ICF associated with hyponatremia
19) Confidence 0.02 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2939538 Disease Relevance 0.46 Pain Relevance 0
The fluctuation of both the ECF and ICF volume are also attenuated (Figure 4C and 4D).
Positive_regulation (fluctuation) of ICF
20) Confidence 0.01 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2939538 Disease Relevance 0 Pain Relevance 0

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