INT73180

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Context Info
Confidence 0.37
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.41
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa8) protein folding (Hspa8) cytosol (Hspa8)
intracellular (Hspa8) protein complex (Hspa8) response to stress (Hspa8)
Anatomy Link Frequency
plasma 1
brain 1
body 1
Hspa8 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 19 99.04 Very High Very High Very High
chemokine 4 97.62 Very High Very High Very High
Neurotransmitter 1 84.08 Quite High
cocaine 2 80.72 Quite High
midbrain 9 56.04 Quite High
ischemia 7 52.20 Quite High
Calcium channel 6 36.48 Quite Low
fibrosis 1 33.76 Quite Low
Inflammation 64 25.00 Low Low
Action potential 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 26 100.00 Very High Very High Very High
Infection 11 96.80 Very High Very High Very High
Hepatotoxicity 4 95.36 Very High Very High Very High
Paralysis 2 94.88 High High
Stress 55 89.92 High High
Targeted Disruption 17 87.72 High High
Atherosclerosis 107 85.92 High High
Toxicity 10 85.12 High High
Apoptosis 22 83.64 Quite High
Ataxia 34 78.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One well-studied functional cluster of genes involved in the folding of cytosolic proteins includes Hspa8, a variety of DnaJs, nucleotide exchange factors Bag1 and Hspbp1 (releasing Hspa8 of ADP), and Hspabp, a stabilizing factor for ADP-bound Hspa8.
Positive_regulation (stabilizing) of Hspa8
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.08 Pain Relevance 0.03
Amphetamine treatment caused an acute rise in core body temperature to 40 degrees C for at least 1 hr and increased hsp25 and hsp70i levels, as measured by Western blotting, at 6, 24, 48, and 72 hr with no apparent induction of other hsps (hsp60, hsc70, or hsp90).
Neg (no) Positive_regulation (induction) of hsc70 in body
2) Confidence 0.31 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9439720 Disease Relevance 0.48 Pain Relevance 0.20
Some representative examples include proinflammatory genes such as Interleukin 8 (IL-8) and chemokine (C-X-C motif) ligand 1 (CXCL1) production, immune response genes such as Interleukin 11 (IL-11) and UPR genes such as activating transcription factor 4 (ATF 4), heat shock 70 kDa protein 8 (HSPA8) and X-box binding protein 1 (XBP1).
Positive_regulation (activating) of heat shock 70 kDa protein 8 associated with chemokine and shock
3) Confidence 0.31 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2761850 Disease Relevance 0.36 Pain Relevance 0.05
Some representative examples include proinflammatory genes such as Interleukin 8 (IL-8) and chemokine (C-X-C motif) ligand 1 (CXCL1) production, immune response genes such as Interleukin 11 (IL-11) and UPR genes such as activating transcription factor 4 (ATF 4), heat shock 70 kDa protein 8 (HSPA8) and X-box binding protein 1 (XBP1).
Positive_regulation (activating) of HSPA8 associated with chemokine and shock
4) Confidence 0.31 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2761850 Disease Relevance 0.36 Pain Relevance 0.05
In the transfected HeLa cells, unlike in the brain, there is apparent induction of Hsc70 chaperone.
Positive_regulation (induction) of Hsc70 in brain
5) Confidence 0.19 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.53 Pain Relevance 0
We examined changes in survival ratio, plasma APAP level and alanine aminotransferase (ALT) activity, and hepatic reduced glutathione (GSH), HSP25, HSP60, HSC70 and HSP70i levels following treatment of mice with APAP (500 mg/kg, p.o.).
Spec (examined) Positive_regulation (following) of HSC70 in plasma associated with paracetamol
6) Confidence 0.16 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.32 Pain Relevance 0.98
It was suggested that Hsc70 induction was a response to cell proliferation stimulus, presumably via the action of T-antigen.
Positive_regulation (induction) of Hsc70
7) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515219 Disease Relevance 0.57 Pain Relevance 0.03
interacts with and activates the ATPase activity of Hsc70 (70 kDa heat shock cognate protein) [14], [15] and Hsp70 (70 kDa heat shock protein) [16].
Positive_regulation (activates) of heat shock cognate associated with shock
8) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883571 Disease Relevance 0.72 Pain Relevance 0.04

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