INT7327

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2010
Negated 30
Speculated 14
Reported most in Abstract
Documents 164
Total Number 178
Disease Relevance 29.67
Pain Relevance 110.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
brain 20
PVN 10
neurons 9
chromaffin cells 6
ventricle 5
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 395 100.00 Very High Very High Very High
Dopamine 356 100.00 Very High Very High Very High
withdrawal 249 100.00 Very High Very High Very High
Enkephalin 207 100.00 Very High Very High Very High
fluoxetine 161 100.00 Very High Very High Very High
Catecholamine 157 100.00 Very High Very High Very High
Locus ceruleus 110 100.00 Very High Very High Very High
Ventral tegmentum 104 100.00 Very High Very High Very High
narcan 104 100.00 Very High Very High Very High
Neuropeptide 98 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 61 100.00 Very High Very High Very High
Generalized Anxiety Disorder 10 100.00 Very High Very High Very High
Toxocariasis 89 99.68 Very High Very High Very High
Ganglion Cysts 66 99.24 Very High Very High Very High
Injury 21 99.20 Very High Very High Very High
Sprains And Strains 21 99.10 Very High Very High Very High
Aids-related Complex 10 98.98 Very High Very High Very High
Hypertension 32 98.92 Very High Very High Very High
Hypoxia 12 98.88 Very High Very High Very High
Morphine Dependence 13 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of preprosomatostatin mRNA and tyrosine hydroxylase mRNA were examined in sympathetic neurons of the rat superior cervical ganglion (SCG).
Regulation (Regulation) of tyrosine hydroxylase in neurons associated with ganglion cysts
1) Confidence 0.62 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2564623 Disease Relevance 0.37 Pain Relevance 0.09
Differential regulation of the tyrosine hydroxylase and enkephalin neuropeptide transmitter genes in rat PC12 cells by short chain fatty acids: concentration-dependent effects on transcription and RNA stability.
Regulation (regulation) of tyrosine hydroxylase associated with neuropeptide and enkephalin
2) Confidence 0.62 Published 2007 Journal Brain Res. Section Title Doc Link 17174279 Disease Relevance 0 Pain Relevance 0.42
Regulation of tyrosine hydroxylase (TH) by second messenger pathway activators was examined in rat olfactory bulb cell cultures.
Regulation (Regulation) of TH in olfactory bulb
3) Confidence 0.61 Published 1994 Journal Brain Res. Section Abstract Doc Link 7834330 Disease Relevance 0 Pain Relevance 0.36
Regulation of tyrosine hydroxylase in olfactory bulb cultures: selective inhibition of depolarization-induced increase by endogenous opioids.
Regulation (Regulation) of tyrosine hydroxylase in olfactory bulb associated with endogenous opioid
4) Confidence 0.61 Published 1994 Journal Brain Res. Section Title Doc Link 7834330 Disease Relevance 0 Pain Relevance 0.62
Regulation of tyrosine hydroxylase (TH) by second messenger pathway activators was examined in rat olfactory bulb cell cultures.
Regulation (Regulation) of tyrosine hydroxylase in olfactory bulb
5) Confidence 0.61 Published 1994 Journal Brain Res. Section Abstract Doc Link 7834330 Disease Relevance 0 Pain Relevance 0.33
The present study was designed to investigate the role of protein kinase C (PKC) in this process by estimating changes in PKCalpha and PKCgamma immunoreactivity, and whether pharmacological inhibition of PKC would attenuate morphine withdrawal-induced c-Fos expression and changes in tyrosine hydroxylase (TH) immunoreactivity levels in the PVN and nucleus tractus solitarius/ ventrolateral medulla (NTS/VLM).
Regulation (changes) of tyrosine hydroxylase in nucleus associated with medulla, kinase c, toxocariasis, withdrawal and morphine
6) Confidence 0.61 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16190878 Disease Relevance 0.37 Pain Relevance 1.29
In the carotid body, nicotine increased TH mRNA expression in animals at 0 and 3 postnatal days (both, P < 0.05 vs. control) without affecting TH mRNA levels at 6 and 15 days.
Neg (without) Regulation (affecting) of TH mRNA in carotid body associated with nicotine
7) Confidence 0.61 Published 2001 Journal J. Appl. Physiol. Section Abstract Doc Link 11641357 Disease Relevance 0.44 Pain Relevance 0.64
Regulation of tyrosine hydroxylase levels and activity and Fos expression during opioid withdrawal in the hypothalamic PVN and medulla oblongata catecholaminergic cell groups innervating the PVN.
Regulation (Regulation) of tyrosine hydroxylase in medulla oblongata associated with medulla, narcan, withdrawal and opioid
8) Confidence 0.61 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 12534973 Disease Relevance 0.34 Pain Relevance 1.07
Although long-term adaptations of LC neurons have previously been implicated in the development of morphine tolerance, dependence, and withdrawal, alterations in the levels of TH, GAL, or NPY mRNA in the LC apparently do not underlie this process.
Regulation (alterations) of TH in neurons associated with addiction, locus ceruleus, tolerance, withdrawal and morphine
9) Confidence 0.60 Published 1995 Journal Synapse Section Abstract Doc Link 7540319 Disease Relevance 0.05 Pain Relevance 1.53
This study was undertaken to investigate the effects of the administration of 3,4-methylenedioxymethamphetamine (MDMA) on the locus coeruleus firing rate, on the sensitivity of the alpha(2)-adrenoceptors which regulate neuronal activity and on the in vivo tyrosine hydroxylase activity in hippocampus.
Regulation (sensitivity) of tyrosine hydroxylase in locus coeruleus associated with locus ceruleus and hippocampus
10) Confidence 0.60 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12536039 Disease Relevance 0 Pain Relevance 0.32
In contrast, the basal levels of c-fos and TH mRNAs were not altered in hypox rat adrenal.
Neg (not) Regulation (altered) of TH
11) Confidence 0.60 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8102782 Disease Relevance 0.06 Pain Relevance 0.23
The effects of MTZ on c-fos, PPenk, and TH mRNAs were dose dependent in both adrenal and hippocampus.
Regulation (dependent) of TH in hippocampus associated with hippocampus
12) Confidence 0.60 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8102782 Disease Relevance 0.08 Pain Relevance 0.26
Northern blot analysis demonstrated that reserpine did not alter the size of either PPenk or TH mRNAs.
Neg (not) Regulation (alter) of TH
13) Confidence 0.60 Published 1991 Journal Mol. Pharmacol. Section Abstract Doc Link 1717819 Disease Relevance 0 Pain Relevance 0.15
We studied the alterations in tyrosine hydroxylase (the rate-limiting enzyme in catecholamines biosynthesis) and tyrosine hydroxylase activity in the heart (right and left ventricle) during morphine withdrawal.
Regulation (alterations) of tyrosine hydroxylase in ventricle associated with catecholamine, withdrawal and morphine
14) Confidence 0.59 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15588731 Disease Relevance 0.10 Pain Relevance 0.88
Intra-VTA infusion of ERK1 antisense oligonucleotides mimicked the effects of chronic BDNF infusions on ERK immunoreactivity, ERK activity, and TH immunoreactivity in the VTA under both control and morphine-treated conditions.
Regulation (immunoreactivity) of TH associated with ventral tegmentum and morphine
15) Confidence 0.54 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8764658 Disease Relevance 0.09 Pain Relevance 1.22
Sodium channel blockade with tetrodotoxin prevented the effects of veratridine on SS and TH mRNAs.
Regulation (effects) of TH associated with tetrodotoxin and sodium channel
16) Confidence 0.54 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2564623 Disease Relevance 0.33 Pain Relevance 0.15
Our results suggest a novel mode of regulation for TH by butyrate operating via both transcriptional and post-transcriptional mechanisms.
Regulation (regulation) of TH
17) Confidence 0.54 Published 2007 Journal Brain Res. Section Abstract Doc Link 17174279 Disease Relevance 0 Pain Relevance 0.15
The role of spinal pathways in the regulation of tyrosine hydroxylase activity (ATHA) in the adrenal medulla was characterized in adult rats with surgical transection of the upper thoracic cord.
Regulation (regulation) of tyrosine hydroxylase in upper associated with medulla
18) Confidence 0.51 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6133231 Disease Relevance 0 Pain Relevance 0.28
Participation of spinal monoaminergic and cholinergic systems in the regulation of adrenal tyrosine hydroxylase.
Regulation (regulation) of tyrosine hydroxylase in spinal associated with monoamine
19) Confidence 0.51 Published 1983 Journal Neuropharmacology Section Title Doc Link 6133231 Disease Relevance 0 Pain Relevance 0.34
It is possible that an alpha-adrenergic system participates in the regulation of tyrosine hydroxylase activity in the adrenal medulla.
Regulation (regulation) of tyrosine hydroxylase in adrenal medulla associated with medulla
20) Confidence 0.51 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6133231 Disease Relevance 0 Pain Relevance 0.32

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