INT73355

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Context Info
Confidence 0.47
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.35
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Slc8a1) plasma membrane (Slc8a1) transmembrane transport (Slc8a1)
response to stress (Slc8a1)
Anatomy Link Frequency
plasma 1
cerebellar granule cells 1
neurons 1
Slc8a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 3 99.12 Very High Very High Very High
aspirin 12 98.24 Very High Very High Very High
ischemia 114 97.00 Very High Very High Very High
Pain 19 94.72 High High
Glutamate 180 89.20 High High
Glutamate receptor 7 80.08 Quite High
antagonist 5 76.44 Quite High
Calcium channel 1 75.00 Quite High
Central nervous system 3 71.12 Quite High
nMDA receptor 72 61.36 Quite High
Disease Link Frequency Relevance Heat
Injury 20 99.68 Very High Very High Very High
Cv Unclassified Under Development 32 97.00 Very High Very High Very High
Hypertension 2 95.96 Very High Very High Very High
Cv General 4 Under Development 6 95.48 Very High Very High Very High
Pain 22 94.72 High High
Aberrant Crypt Foci 3 92.72 High High
Apoptosis 99 90.08 High High
Neuroblastoma 3 83.52 Quite High
Death 92 79.24 Quite High
Adenocarcinoma 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies demonstrated that inhibition of NCX1 by substitution of Na+ with Li+ and Cs+ affects NMDA-induced intracellular Ca2+ increase in glucose-deprived and depolarized cerebellar granule cells (Blaustein & Lederer, 1999; Kiedrowski 1999).
Negative_regulation (inhibition) of NCX1 in cerebellar granule cells
1) Confidence 0.47 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.33 Pain Relevance 0.27
In contrast, KB-R 7943 (2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulphonate; 1 and 3 microM), a highly potent and selective inhibitor of the Na+/Ca2+ exchanger (NCX1), failed to inhibit the K+- and veratridine-induced increase in [Ca2+]i.
Negative_regulation (inhibitor) of NCX1
2) Confidence 0.40 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9453466 Disease Relevance 0 Pain Relevance 0.11
After NCX1 reverses, any further depolarization of the plasma membrane increases the electrochemical driving force of Ca2+ influx via this pathway (Hansen & Zeuthen, 1981; Benveniste et al., 1984).
Negative_regulation (reverses) of NCX1 in plasma
3) Confidence 0.35 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.42 Pain Relevance 0.28
For example, NCX inhibitors have been suggested for the treatment of cardiovascular disorders such as ischemia, arrhythmias and hypertension [76].
Negative_regulation (inhibitors) of NCX associated with ischemia and hypertension
4) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0.87 Pain Relevance 0.23
This proteolytic inactivation of NCX could allow further accumulation of Ca2+ or delay its elimination, that ultimately results in the destruction of the neurons.
Negative_regulation (inactivation) of NCX in neurons
5) Confidence 0.05 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0.27 Pain Relevance 0.14
Despite not inhibiting COX, NCX-4016 exhibited comparable analgesic activity to aspirin.
Negative_regulation (inhibiting) of NCX-4016 associated with aspirin and analgesic
6) Confidence 0.03 Published 1998 Journal Life Sci. Section Abstract Doc Link 9627095 Disease Relevance 0.46 Pain Relevance 0.59

General Comments

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