INT73465

Context Info Confidence 0.07 First Reported 1997 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 3.47 Pain Relevance 0.96

cytosol (TSC1) embryo development (TSC1) protein complex (TSC1) cytoplasm (TSC1)

Anatomy Link Frequency colon 1 TSC1 (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 14 99.72 Somatostatin 2 5.00 palliative 1 5.00 Chronic pancreatitis 1 5.00 COX-2 inhibitor 1 5.00 cINOD 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Cancer 163 100.00 Colon Cancer 22 99.54 Stomach Cancer 3 94.16 Congenital Anomalies 22 89.44 Skin Cancer 2 83.36 Nicotine Addiction 44 81.92 Glioma 1 81.92 Lung Cancer 77 77.28 Pancreatic Ductal Carcinoma 2 76.24 Apoptosis 12 75.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

DNA hypermethylation can inhibit transcription of tumor suppressor genes and mismatch repair genes (p16, hMLH1 and VHL), providing an epigenetic mechanism of selection during tumorigenesis [11,12].

Transcription (transcription) of tumor suppressor associated with cancer

1) Confidence 0.07 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 1.10 Pain Relevance 0

Previous studies from our laboratory have identified a number of miRNAs that were deregulated in colon cancer cell lines due to the deletion of the p53 tumor suppressor gene.

Transcription (deletion) of tumor suppressor in colon associated with cancer and colon cancer

2) Confidence 0.06 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2134920 Disease Relevance 0.43 Pain Relevance 0

In addition to being markers of carcinogen exposure, it is possible that these adducts may directly alter regulation of transcription of tumor suppressor or oncogenes [74].

Transcription (transcription) of tumor suppressor associated with cancer

3) Confidence 0.05 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 0.95 Pain Relevance 0

It was found that CAP enhanced the transcripts of two proto-oncogenes (c-myc and c-Ha-ras) and tumor suppressor gene p53.

Transcription (transcripts) of tumor suppressor gene associated with qutenza and cancer

4) Confidence 0.01 Published 1997 Journal Cancer Lett. Section Abstract Doc Link 9461043 Disease Relevance 0.99 Pain Relevance 0.96

General Comments

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