INT73465

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Context Info
Confidence 0.07
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.47
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TSC1) embryo development (TSC1) protein complex (TSC1)
cytoplasm (TSC1)
Anatomy Link Frequency
colon 1
TSC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 14 99.72 Very High Very High Very High
Somatostatin 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 163 100.00 Very High Very High Very High
Colon Cancer 22 99.54 Very High Very High Very High
Stomach Cancer 3 94.16 High High
Congenital Anomalies 22 89.44 High High
Skin Cancer 2 83.36 Quite High
Nicotine Addiction 44 81.92 Quite High
Glioma 1 81.92 Quite High
Lung Cancer 77 77.28 Quite High
Pancreatic Ductal Carcinoma 2 76.24 Quite High
Apoptosis 12 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DNA hypermethylation can inhibit transcription of tumor suppressor genes and mismatch repair genes (p16, hMLH1 and VHL), providing an epigenetic mechanism of selection during tumorigenesis [11,12].
Transcription (transcription) of tumor suppressor associated with cancer
1) Confidence 0.07 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 1.10 Pain Relevance 0
Previous studies from our laboratory have identified a number of miRNAs that were deregulated in colon cancer cell lines due to the deletion of the p53 tumor suppressor gene.
Transcription (deletion) of tumor suppressor in colon associated with cancer and colon cancer
2) Confidence 0.06 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2134920 Disease Relevance 0.43 Pain Relevance 0
In addition to being markers of carcinogen exposure, it is possible that these adducts may directly alter regulation of transcription of tumor suppressor or oncogenes [74].
Transcription (transcription) of tumor suppressor associated with cancer
3) Confidence 0.05 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 0.95 Pain Relevance 0
It was found that CAP enhanced the transcripts of two proto-oncogenes (c-myc and c-Ha-ras) and tumor suppressor gene p53.
Transcription (transcripts) of tumor suppressor gene associated with qutenza and cancer
4) Confidence 0.01 Published 1997 Journal Cancer Lett. Section Abstract Doc Link 9461043 Disease Relevance 0.99 Pain Relevance 0.96

General Comments

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